Wang lab

Principles behind gene regulation and protein-protein interactions

We are always looking for movitated postdocs in the following areas.

1. Computational Biology and Bioinformatics

An ideal candidate should obtain Ph.D. in bioinformatics/computer science/physics, be highly motivated and have strong programming skills. Extensive knowledge and experience with contemporary computational biology is required. Expertise in machine learning algorithms such as Bayesian network and hidden Markov model is highly recommended.

The postdoc is expected to be responsible for organizing and analyzing in-house epigenomic (histone modification and DNA methylation) and genomic data (ChIP-seq, digital expression profiling) generated by the next generation sequencing technology. He/she will also develop methods to integrate multiple sources of data to understand the mechanisms of transcriptional regulation and reconstruct transcriptional networks in human embryonic stem cells.

2. Computational Biophysics/Chemistry

An ideal candidate should obtain Ph.D. in computational chemistry/biophysics/biology, be highly motivated and have extensive experience with computer modeling such as molecular dynamics simulation, free energy calculation, force field development, homology modeling, entropy calculation and drug design. Solid background in physics and statistics is required. Proficient programming skills are essential. Experience with AMBER is a plus.

Our group is interested in predicting protein binding specificity, understanding the underlying mechanisms and ultimately deciphering the protein recognition code. We are particularly interested in protein-peptide interactions and how to design potent drugs to combat resistance. We have taken interdisciplinary approaches that combine computer modeling and bioinformatics analysis to predict the binding specificity of modular domains. We have also applied the similar approaches to predicting mutations of the HIV-1 protease that cause drug resistance. The postdoc is expected to be responsible for developing new computational methods to tackle these challenging problems.

3. Biochemistry and Molecular Biology

An ideal candidate should obtain Ph.D. in biochemistry/molecular biology, be highly motivated and have extensive experience with protein purification, protein binding assays, such as peptide array, protein array, biacore.

The postdoc is expected to be responsible for conducting in vitro and in vivo experiments to determine protein binding specificity. There will be a close collaboration with computational biologists in the group to integrate experimental and computational analyses for determining and manipulating protein-peptide and protein-ligand interactions.

Interested applicants should send CV and statement of research to wei-wang@ucsd.edu. Please also arrange three letters of recommendation sent directly to the above email address.