Taiji-Reprogram integrates the transcriptomic and epigenomic data to construct cell-type specific genetic networks and assess the global importance of TFs in the network. Comparative analysis across cell types revealed TFs that are specifically important in a particular cell type and often tightly associated with cell-type specific functions. Taiji-reprogram did systematic search of TFs with differential importance in the source and target cell types and uncovered TF combinations for desired cell conversion.