TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_re_11_0.369
CTGTAATCC
0
2_re_23_0.380
GCCTCAGCC
0
3_re_4_0.383
ACGCCTGTA
0
4_re_145_0.386
CAGGAGTTCA
1 RPC155_01_M01798_T
5_re_9_0.386
CAAGCGATTC
0
6_re_5_0.387
AATTAGCCGG
0
7_re_92_0.389
GACTCCAGCC
1 SMAP1L_4_H
8_re_163_0.389
CGTAATCCC
2 bcd_MA0212.1_J,  oc_MA0234.1_J
9_re_146_0.392
AGCTGGGAT
1 LUN1_01_M00480_T
10_re_115_0.395
TGGGCGACA
0
11_re_157_0.396
GTGCGCCAC
0
12_re_76_0.400
TCGAGACCA
0
13_re_74_0.400
CGGGTTCAA
0
14_h_2_0.592
CCACATTCCT
3 TEAD1_MA0090.1_J,  TEF_01_M01305_T,  ABAA_01_M00027_T
15_re_103_0.410
GGAGTTGGA
0
16_re_66_0.414
AGCTACTCG
0
17_re_21_0.417
ACGGTGGCTC
0
18_e_216_0.418
CACTGGAC
0
19_re_64_0.420
GCAACCTCCG
0
20_e_278_0.421
GCAGCACGT
0
21_re_124_0.421
ATCCACCCG
0
22_re_58_0.422
AGGAGAATCG
0
23_re_164_0.424
CTCAGGTGAG
3 sna_MA0086.1_J,  DELTAEF1_01_M00073_T,  RAV1_02_M00344_T
24_e_280_0.425
CATCACGA
0
25_re_65_0.428
GATCTCGGC
0
26_h_6_0.572
AACCGGAAGC
15 ETS_class_MF0001.1_J,  Eip74EF_MA0026.1_J,  ELK4_MA0076.1_J,  SAP1A_01_M01167_T,  ELF2_10_H,  CETS168_Q6_M00743_T,  IXR1_MA0323.1_J,  ETV4_13_H,  ELK1_03_M01163_T,  ELK1_04_M01165_T
27_re_160_0.429
ACCTCAGGT
0
28_h_11_0.571
CTTTCCGGAA
4 PDR1_01_M01519_T,  Pdr1_GR09_U,  Sip4_GR09_U,  SIP4_01_M01517_T
29_re_154_0.432
GCGTGTGCCA
0
30_re_162_0.432
GAGGTGGGCA
0
31_re_91_0.432
ACCTCGTGAT
0
32_h_3_0.564
AAAGCCTGCT
0
33_e_6_0.440
CGGCGCCCGGT
0
34_e_289_0.557
TGTCTGGAA
0
35_h_13_0.557
GTCAGCGAAA
0
36_h_12_0.557
CCAGAGCTGTTT
0
37_e_171_0.555
AGGAAGTGAC
5 ETS1_B_M00339_T,  ETS_Q4_M00771_T,  FLI1_Q6_M01208_T,  SPI1_MA0080.2_J,  ETS2_B_M00340_T
38_h_21_0.551
GGGGGAAAAAAA
0
39_e_274_0.539
TCTGACAGC
2 TGIF_01_M00418_T,  PKNOX2_7_H
40_e_236_0.539
AAAACGCAGAA
0
41_e_328_0.538
ATTCGTAGC
0
42_e_2_0.463
GCAGCGCCCCCGC
0
43_e_167_0.469
CCACAGTGCCT
0
44_re_214_0.531
GAACGTACG
0
45_re_245_0.473
ACACACCTG
1 DDX53_5_H
46_e_317_0.525
CACAGAAGG
1 RARG_9_H
47_e_333_0.523
CAGTCACTT
0
48_e_114_0.521
TACTGACG
0
49_re_278_0.516
TACCGTACA
0
50_re_277_0.487
CACGTTATA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 39

Matches to Query: 1_re_11_0.369

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Matches to Query: 2_re_23_0.380

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Matches to Query: 3_re_4_0.383

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Matches to Query: 4_re_145_0.386

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.83957e-06
E-value 0.0258204
q-value 0.0516408
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 5_re_9_0.386

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Matches to Query: 6_re_5_0.387

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Matches to Query: 7_re_92_0.389

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Summary 

Alignment 

Name SMAP1L_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.35201e-05
E-value 0.0394923
q-value 0.0789847
Overlap 6
Offset -4
Orientation Reverse Complement
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Matches to Query: 8_re_163_0.389

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Summary 

Alignment 

Name bcd_MA0212.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.48625e-05
E-value 0.0434134
q-value 0.0434134
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name oc_MA0234.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.48625e-05
E-value 0.0434134
q-value 0.0434134
Overlap 6
Offset -2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 9_re_146_0.392

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Summary 

Alignment 

Name LUN1_01_M00480_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.52137e-06
E-value 0.00736493
q-value 0.0147299
Overlap 8
Offset 9
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 10_re_115_0.395

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Matches to Query: 11_re_157_0.396

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Matches to Query: 12_re_76_0.400

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Matches to Query: 13_re_74_0.400

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Matches to Query: 14_h_2_0.592

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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.43555e-07
E-value 0.00158772
q-value 0.00158772
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.43555e-07
E-value 0.00158772
q-value 0.00158772
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name ABAA_01_M00027_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.06998e-06
E-value 0.0060464
q-value 0.00403093
Overlap 10
Offset 4
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 15_re_103_0.410

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Matches to Query: 16_re_66_0.414

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Matches to Query: 17_re_21_0.417

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Matches to Query: 18_e_216_0.418

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Matches to Query: 19_re_64_0.420

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Matches to Query: 20_e_278_0.421

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Matches to Query: 21_re_124_0.421

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Matches to Query: 22_re_58_0.422

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Matches to Query: 23_re_164_0.424

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Summary 

Alignment 

Name sna_MA0086.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.13184e-06
E-value 0.0120691
q-value 0.0229847
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name DELTAEF1_01_M00073_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.92714e-06
E-value 0.0231552
q-value 0.0229847
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name RAV1_02_M00344_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.45472e-05
E-value 0.0424923
q-value 0.0281196
Overlap 10
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 24_e_280_0.425

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Matches to Query: 25_re_65_0.428

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Matches to Query: 26_h_6_0.572

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Summary 

Alignment 

Name ETS_class_MF0001.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.00434e-08
E-value 5.85467e-05
q-value 0.000115748
Overlap 8
Offset -1
Orientation Normal
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Summary 

Alignment 

Name Eip74EF_MA0026.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.20809e-07
E-value 0.00239758
q-value 0.00237003
Overlap 7
Offset -2
Orientation Normal
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Summary 

Alignment 

Name ELK4_MA0076.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.93001e-06
E-value 0.00563755
q-value 0.00331804
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name SAP1A_01_M01167_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.29826e-06
E-value 0.00671322
q-value 0.00331804
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ELF2_10_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.90112e-06
E-value 0.0113952
q-value 0.00357959
Overlap 7
Offset -2
Orientation Normal
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Summary 

Alignment 

Name CETS168_Q6_M00743_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.11407e-06
E-value 0.0120172
q-value 0.00357959
Overlap 8
Offset -2
Orientation Normal
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Summary 

Alignment 

Name IXR1_MA0323.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.9745e-06
E-value 0.0145305
q-value 0.00357959
Overlap 10
Offset 1
Orientation Normal
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Summary 

Alignment 

Name ETV4_13_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.71166e-06
E-value 0.0166838
q-value 0.00357959
Overlap 7
Offset -2
Orientation Normal
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Summary 

Alignment 

Name ELK1_03_M01163_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.76433e-06
E-value 0.0168376
q-value 0.00357959
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ELK1_04_M01165_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.19856e-06
E-value 0.018106
q-value 0.00357959
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name IXR1_01_M01683_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.83372e-06
E-value 0.0199613
q-value 0.00358762
Overlap 10
Offset 1
Orientation Normal
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Summary 

Alignment 

Name ERG_01_M01752_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.60463e-06
E-value 0.0251341
q-value 0.00414089
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name ELK1_01_M00007_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.16749e-05
E-value 0.0341025
q-value 0.00518626
Overlap 10
Offset 2
Orientation Normal
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Summary 

Alignment 

Name CETS1P54_01_M00032_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.25744e-05
E-value 0.0367298
q-value 0.00518682
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name ELK1_02_M00025_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.39543e-05
E-value 0.0407604
q-value 0.00537227
Overlap 10
Offset 2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 27_re_160_0.429

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Matches to Query: 28_h_11_0.571

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Summary 

Alignment 

Name PDR1_01_M01519_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.74552e-07
E-value 0.00284667
q-value 0.00282669
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Pdr1_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.74552e-07
E-value 0.00284667
q-value 0.00282669
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Sip4_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.96646e-06
E-value 0.00574403
q-value 0.00334374
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name SIP4_01_M01517_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.30563e-06
E-value 0.00673474
q-value 0.00334374
Overlap 10
Offset 4
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 29_re_154_0.432

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Matches to Query: 30_re_162_0.432

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Matches to Query: 31_re_91_0.432

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Matches to Query: 32_h_3_0.564

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Matches to Query: 33_e_6_0.440

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Matches to Query: 34_e_289_0.557

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Matches to Query: 35_h_13_0.557

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Matches to Query: 36_h_12_0.557

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Matches to Query: 37_e_171_0.555

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Summary 

Alignment 

Name ETS1_B_M00339_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.09119e-06
E-value 0.00318735
q-value 0.00464178
Overlap 10
Offset 2
Orientation Normal
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Summary 

Alignment 

Name ETS_Q4_M00771_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.11859e-06
E-value 0.00618841
q-value 0.00464178
Overlap 10
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name FLI1_Q6_M01208_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.40384e-06
E-value 0.00702161
q-value 0.00464178
Overlap 10
Offset 1
Orientation Normal
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Summary 

Alignment 

Name SPI1_MA0080.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.18503e-06
E-value 0.0151455
q-value 0.00750917
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ETS2_B_M00340_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.24638e-05
E-value 0.0364067
q-value 0.0144404
Overlap 10
Offset 3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 38_h_21_0.551

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Matches to Query: 39_e_274_0.539

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Summary 

Alignment 

Name TGIF_01_M00418_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.65015e-06
E-value 0.0194251
q-value 0.0304869
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name PKNOX2_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.26306e-05
E-value 0.0368938
q-value 0.0304869
Overlap 6
Offset -3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 40_e_236_0.539

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Matches to Query: 41_e_328_0.538

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Matches to Query: 42_e_2_0.463

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Matches to Query: 43_e_167_0.469

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Matches to Query: 44_re_214_0.531

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Matches to Query: 45_re_245_0.473

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Summary 

Alignment 

Name DDX53_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.38461e-06
E-value 0.0244914
q-value 0.0486813
Overlap 5
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 46_e_317_0.525

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Summary 

Alignment 

Name RARG_9_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.61174e-06
E-value 0.0163919
q-value 0.0327838
Overlap 6
Offset -2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 47_e_333_0.523

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Matches to Query: 48_e_114_0.521

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Matches to Query: 49_re_278_0.516

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Matches to Query: 50_re_277_0.487

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 128.455 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.