TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k36me3_0_0.632
GAATCGCTTGA
0
2_e_k36me3_3_0.632
CGCCTGTAA
0
3_e_k36me3_61_0.620
GTGAGCCAC
0
4_e_k36me3_57_0.619
CTGGGCAACA
0
5_e_k36me3_26_0.614
CAGCCTCCCG
0
6_e_k36me3_83_0.613
CAGGAGTTCA
1 RPC155_01_M01798_T
7_e_k36me3_99_0.612
AGGCTGGTC
2 SMAP1L_4_H,  TRIM21_5_H
8_e_k36me3_51_0.611
CAGCTACTCA
0
9_e_k36me3_76_0.611
ATCCCAGCA
0
10_e_k36me3_52_0.608
GCCTCAGCC
0
11_e_k36me3_111_0.607
CAGTGGTGCG
0
12_e_k36me3_21_0.605
AACCCCGTC
0
13_e_k36me3_112_0.604
AAGTGCTGG
0
14_e_k36me3_28_0.596
AGTTCGAGA
0
15_e_k36me3_75_0.591
CTCGGCTCA
0
16_e_k36me3_160_0.588
AGTACAGTG
0
17_e_k36me3_234_0.584
ATCCTGGCC
0
18_e_k36me3_59_0.583
AACCTCCGC
0
19_e_k36me3_82_0.582
ATGCCTGGC
0
20_e_k36me3_40_0.579
GATCTCGGC
0
21_e_k36me3_114_0.573
AGGTGTGTG
1 TBX5_Q5_M01044_T
22_e_k36me3_166_0.564
CGCCTTGGC
0
23_e_k36me3_129_0.563
CGGATCACC
0
24_e_k36me3_158_0.563
ACCTCAGGTGA
2 RAV1_02_M00344_T,  sna_MA0086.1_J
25_e_k36me3_118_0.561
CCACCTGCC
3 E2A_Q2_M00804_T,  E2A_Q6_M00973_T,  E12_Q6_M00693_T
26_e_k4me3_59_0.560
ACTCGCGAG
0
27_e_k4me3_188_0.560
ACTGCGGT
0
28_e_k4me3_77_0.559
CGCGGTAC
0
29_e_k36me3_132_0.558
CTGTCGCCC
0
30_e_k36me3_233_0.551
CATCGTGCC
0
31_h_k4me3_2_0.548
TAATCGTT
0
32_e_k36me3_155_0.548
GCAAACGTGGCTA
0
33_e_k36me3_121_0.542
CCGTGTTAG
0
34_e_k4me3_335_0.542
CCGATTTG
0
35_e_k9me3_315_0.458
AGATTTGGGG
0
36_e_k36me3_106_0.541
ACCGTGCCC
0
37_h_k27me3_18_0.540
TTGCCGCT
0
38_e_k9me3_281_0.460
TCATGAGAAC
0
39_h_k27me3_15_0.460
GAAAGGGAGC
0
40_e_k36me3_235_0.538
TACGTAGTA
0
41_h_k27me3_9_0.463
GGCGGGCGAGAG
0
42_e_k9me3_104_0.464
AACGGGAATT
0
43_e_k9me3_251_0.464
TCTCAGAAAA
0
44_e_k36me3_175_0.536
ACCGACGA
0
45_e_k36me3_248_0.535
AACGCTACC
0
46_h_k9me3_25_0.466
TGGGGCCGCC
0
47_e_k27ac_285_0.467
AGAAATTCC
0
48_h_k9me3_6_0.468
CCAATCAATGAG
0
49_h_k4me3_32_0.531
CGCCTTAACCAC
0
50_e_k9me3_379_0.469
CAGGGAGTG
0
51_e_k27ac_148_0.470
GAGGAGAAAGGA
0
52_e_k9me3_123_0.470
CAGATATTTC
0
53_e_k36me3_273_0.530
ACAGTCACG
0
54_e_k4me3_204_0.530
AACGATTA
0
55_e_k9me3_305_0.471
TCCCTCACA
0
56_e_k36me3_230_0.529
ACGACGTAC
0
57_e_k27me3_332_0.528
ACGTTTTAA
0
58_e_k27me3_79_0.472
CGGAGCGGA
1 MED-1_POL013.1_J
59_e_k9me3_7_0.472
CCAACGAAA
0
60_h_k36me3_20_0.527
CGCCAGCG
0
61_e_k9me3_6_0.473
TGATGATTCC
0
62_e_k9me3_3_0.473
ATGGAATGG
0
63_h_k9me3_5_0.474
CCCTTGCAGCTA
0
64_h_k4me3_8_0.526
TCGTAACG
0
65_h_k9me3_16_0.474
AGCGGTCCAAAT
2 NR4A2_4_H,  WHSC2_6_H
66_e_k4me1_83_0.524
GGCCAGTGCC
0
67_h_k4me3_4_0.524
TCGCGTTT
0
68_e_k27ac_274_0.478
CAGCTCTCA
0
69_e_k4me3_336_0.522
TAATTACGA
0
70_e_k4me3_256_0.521
CCGTGCTTT
0
71_e_k4me3_159_0.479
GGATTCGAA
2 BRF1_01_M01747_T,  BDP1_01_M01796_T
72_h_k27ac_15_0.479
GGCTTGAAAG
0
73_e_k36me3_354_0.521
ATGTGCCAG
0
74_e_k27ac_350_0.480
CCTTTGTT
13 SOX4_01_M01308_T,  Sox4_primary_SCI09_U,  Sox11_primary_SCI09_U,  Sox4_CR09_U,  Fkh2_GR09_U,  FKH2_01_M01533_T,  MAT1MC_01_M00275_T,  FKH1_01_M01507_T,  FKH1_MA0296.1_J,  Fkh1_GR09_U
75_h_k4me3_31_0.519
TTAACAGT
0
76_e_k9me3_61_0.481
GATTGTGAG
0
77_h_k27ac_22_0.482
GTGTGTGTGTGT
0
78_e_k9me3_162_0.484
ATGCACACA
0
79_e_k9me3_21_0.484
GCATGTGGAGTC
0
80_e_k4me1_439_0.516
AATGCTGACA
0
81_e_k9me3_119_0.485
GAGACATGC
0
82_e_k9me3_351_0.485
AGACCAGGG
0
83_e_k27me3_248_0.488
GAGGAAGGA
0
84_h_k9me3_17_0.488
CATAGGCCTCAA
0
85_e_k27ac_326_0.512
AGTCTGGAG
1 UGP2_3_H
86_e_k9me3_184_0.489
TCAGCAAGG
0
87_e_k4me1_404_0.511
TGCTAAGCA
0
88_e_k9me3_18_0.491
ATGATAGAGCA
0
89_e_k27me3_190_0.505
AATAAACGC
1 APOLYA_B_M00310_T
90_e_k4me1_387_0.498
GCTTTGGAAA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 29

Matches to Query: 1_e_k36me3_0_0.632

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Matches to Query: 2_e_k36me3_3_0.632

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Matches to Query: 3_e_k36me3_61_0.620

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Matches to Query: 4_e_k36me3_57_0.619

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Matches to Query: 5_e_k36me3_26_0.614

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Matches to Query: 6_e_k36me3_83_0.613

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.78308e-06
E-value 0.0139714
q-value 0.0279427
Overlap 10
Offset 1
Orientation Normal
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Matches to Query: 7_e_k36me3_99_0.612

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Summary 

Alignment 

Name SMAP1L_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.23938e-06
E-value 0.00654122
q-value 0.0130824
Overlap 6
Offset -1
Orientation Normal
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Summary 

Alignment 

Name TRIM21_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.15642e-06
E-value 0.0267459
q-value 0.0267459
Overlap 6
Offset -1
Orientation Normal
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Matches to Query: 8_e_k36me3_51_0.611

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Matches to Query: 9_e_k36me3_76_0.611

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Matches to Query: 10_e_k36me3_52_0.608

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Matches to Query: 11_e_k36me3_111_0.607

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Matches to Query: 12_e_k36me3_21_0.605

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Matches to Query: 13_e_k36me3_112_0.604

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Matches to Query: 14_e_k36me3_28_0.596

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Matches to Query: 15_e_k36me3_75_0.591

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Matches to Query: 16_e_k36me3_160_0.588

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Matches to Query: 17_e_k36me3_234_0.584

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Matches to Query: 18_e_k36me3_59_0.583

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Matches to Query: 19_e_k36me3_82_0.582

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Matches to Query: 20_e_k36me3_40_0.579

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Matches to Query: 21_e_k36me3_114_0.573

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Summary 

Alignment 

Name TBX5_Q5_M01044_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.18949e-06
E-value 0.00347449
q-value 0.00694684
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 22_e_k36me3_166_0.564

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Matches to Query: 23_e_k36me3_129_0.563

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Matches to Query: 24_e_k36me3_158_0.563

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Summary 

Alignment 

Name RAV1_02_M00344_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.10458e-06
E-value 0.00614746
q-value 0.00815002
Overlap 11
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name sna_MA0086.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.81771e-06
E-value 0.00823054
q-value 0.00815002
Overlap 6
Offset -4
Orientation Normal
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Matches to Query: 25_e_k36me3_118_0.561

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Summary 

Alignment 

Name E2A_Q2_M00804_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.09004e-06
E-value 0.02071
q-value 0.0235194
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name E2A_Q6_M00973_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.06963e-05
E-value 0.031244
q-value 0.0235194
Overlap 8
Offset -1
Orientation Normal
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Summary 

Alignment 

Name E12_Q6_M00693_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.4759e-05
E-value 0.0431111
q-value 0.0235194
Overlap 9
Offset 2
Orientation Reverse Complement
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Matches to Query: 26_e_k4me3_59_0.560

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Matches to Query: 27_e_k4me3_188_0.560

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Matches to Query: 28_e_k4me3_77_0.559

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Matches to Query: 29_e_k36me3_132_0.558

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Matches to Query: 30_e_k36me3_233_0.551

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Matches to Query: 31_h_k4me3_2_0.548

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Matches to Query: 32_e_k36me3_155_0.548

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Matches to Query: 33_e_k36me3_121_0.542

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Matches to Query: 34_e_k4me3_335_0.542

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Matches to Query: 35_e_k9me3_315_0.458

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Matches to Query: 36_e_k36me3_106_0.541

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Matches to Query: 37_h_k27me3_18_0.540

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Matches to Query: 38_e_k9me3_281_0.460

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Matches to Query: 39_h_k27me3_15_0.460

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Matches to Query: 40_e_k36me3_235_0.538

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Matches to Query: 41_h_k27me3_9_0.463

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Matches to Query: 42_e_k9me3_104_0.464

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Matches to Query: 43_e_k9me3_251_0.464

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Matches to Query: 44_e_k36me3_175_0.536

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Matches to Query: 45_e_k36me3_248_0.535

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Matches to Query: 46_h_k9me3_25_0.466

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Matches to Query: 47_e_k27ac_285_0.467

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Matches to Query: 48_h_k9me3_6_0.468

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Matches to Query: 49_h_k4me3_32_0.531

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Matches to Query: 50_e_k9me3_379_0.469

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Matches to Query: 51_e_k27ac_148_0.470

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Matches to Query: 52_e_k9me3_123_0.470

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Matches to Query: 53_e_k36me3_273_0.530

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Matches to Query: 54_e_k4me3_204_0.530

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Matches to Query: 55_e_k9me3_305_0.471

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Matches to Query: 56_e_k36me3_230_0.529

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Matches to Query: 57_e_k27me3_332_0.528

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Matches to Query: 58_e_k27me3_79_0.472

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Summary 

Alignment 

Name MED-1_POL013.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.52477e-05
E-value 0.0445387
q-value 0.0890773
Overlap 6
Offset 0
Orientation Reverse Complement
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Matches to Query: 59_e_k9me3_7_0.472

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Matches to Query: 60_h_k36me3_20_0.527

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Matches to Query: 61_e_k9me3_6_0.473

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Matches to Query: 62_e_k9me3_3_0.473

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Matches to Query: 63_h_k9me3_5_0.474

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Matches to Query: 64_h_k4me3_8_0.526

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Matches to Query: 65_h_k9me3_16_0.474

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Summary 

Alignment 

Name NR4A2_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.12192e-05
E-value 0.0327712
q-value 0.0327712
Overlap 7
Offset -5
Orientation Reverse Complement
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Summary 

Alignment 

Name WHSC2_6_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.12192e-05
E-value 0.0327712
q-value 0.0327712
Overlap 7
Offset -5
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 66_e_k4me1_83_0.524

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Matches to Query: 67_h_k4me3_4_0.524

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Matches to Query: 68_e_k27ac_274_0.478

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Matches to Query: 69_e_k4me3_336_0.522

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Matches to Query: 70_e_k4me3_256_0.521

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Matches to Query: 71_e_k4me3_159_0.479

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Summary 

Alignment 

Name BRF1_01_M01747_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.36646e-07
E-value 0.00185964
q-value 0.00371929
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name BDP1_01_M01796_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.49257e-05
E-value 0.0435979
q-value 0.0435979
Overlap 9
Offset 0
Orientation Normal
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Matches to Query: 72_h_k27ac_15_0.479

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Matches to Query: 73_e_k36me3_354_0.521

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Matches to Query: 74_e_k27ac_350_0.480

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Summary 

Alignment 

Name SOX4_01_M01308_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.88309e-08
E-value 0.000288685
q-value 0.000481752
Overlap 8
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox4_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.66035e-07
E-value 0.000484988
q-value 0.000481752
Overlap 8
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox11_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.60799e-07
E-value 0.000761794
q-value 0.000504474
Overlap 8
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox4_CR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.19841e-07
E-value 0.00151845
q-value 0.000754161
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name Fkh2_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.09674e-06
E-value 0.0148876
q-value 0.0042396
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name FKH2_01_M01533_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.17586e-06
E-value 0.0180397
q-value 0.0042396
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name MAT1MC_01_M00275_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.29329e-06
E-value 0.0183827
q-value 0.0042396
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name FKH1_01_M01507_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.43752e-06
E-value 0.021725
q-value 0.0042396
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name FKH1_MA0296.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.43752e-06
E-value 0.021725
q-value 0.0042396
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name Fkh1_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.43752e-06
E-value 0.021725
q-value 0.0042396
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name SMAD1_01_M01590_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.03644e-06
E-value 0.0234744
q-value 0.0042396
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name STE11_02_M01005_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.26251e-05
E-value 0.0368778
q-value 0.00610528
Overlap 8
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name SOX2_Q6_M01272_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.44652e-05
E-value 0.0422527
q-value 0.00645704
Overlap 8
Offset 4
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 75_h_k4me3_31_0.519

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Matches to Query: 76_e_k9me3_61_0.481

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Matches to Query: 77_h_k27ac_22_0.482

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Matches to Query: 78_e_k9me3_162_0.484

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Matches to Query: 79_e_k9me3_21_0.484

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Matches to Query: 80_e_k4me1_439_0.516

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Matches to Query: 81_e_k9me3_119_0.485

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Matches to Query: 82_e_k9me3_351_0.485

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Matches to Query: 83_e_k27me3_248_0.488

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Matches to Query: 84_h_k9me3_17_0.488

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Matches to Query: 85_e_k27ac_326_0.512

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Summary 

Alignment 

Name UGP2_3_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.16991e-05
E-value 0.0341731
q-value 0.0683463
Overlap 6
Offset -3
Orientation Normal
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Matches to Query: 86_e_k9me3_184_0.489

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Matches to Query: 87_e_k4me1_404_0.511

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Matches to Query: 88_e_k9me3_18_0.491

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Matches to Query: 89_e_k27me3_190_0.505

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Summary 

Alignment 

Name APOLYA_B_M00310_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.8394e-07
E-value 0.00112149
q-value 0.00224298
Overlap 9
Offset 0
Orientation Normal
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Matches to Query: 90_e_k4me1_387_0.498

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 215.521 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.