TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_134_0.556
CAGCCTCCAG
0
2_re_30_0.447
TCCTCCTTCCCT
0
3_e_334_0.550
CTCATGAGA
0
4_re_65_0.452
AGAGAAGAG
0
5_e_55_0.545
AACGTGGTGA
1 TAF9_2_H
6_re_40_0.455
ATTCATTCA
1 Hbp1_primary_SCI09_U
7_re_43_0.456
GGATGAGGAA
0
8_re_60_0.458
CAGGCACTG
0
9_e_176_0.542
CCAGTCTCGG
0
10_re_38_0.459
GCCTGGCAC
0
11_e_345_0.540
CAAGATGGC
2 YY1_02_M00069_T,  YY1_Q6_M00793_T
12_e_211_0.540
ACATGGTGG
0
13_re_19_0.460
AGGAAGAAAA
0
14_re_13_0.460
CTCTGTGCC
0
15_re_71_0.461
TGCCAGGCA
0
16_re_63_0.461
GGGGAAAAA
0
17_re_48_0.461
TGGGCAGGGAT
0
18_re_64_0.464
CAGAGCTGGA
0
19_e_259_0.536
ACCATATCA
0
20_e_197_0.535
GGGTGACATA
0
21_e_100_0.535
TATCACAGCA
0
22_re_57_0.465
TACAGATGACG
0
23_e_249_0.534
CCAACGTGAG
0
24_re_68_0.467
GCACAGTGC
0
25_e_309_0.532
GAGAACAGCAG
0
26_e_226_0.532
ACTAATACA
0
27_re_28_0.469
AATACACGT
0
28_e_376_0.531
ACAATCACG
0
29_re_82_0.470
ATACTTACG
0
30_re_22_0.470
CCTCAGTTTC
0
31_re_56_0.471
GCAAGGTCAC
8 ERR2_01_M01589_T,  NR4A2_MA0160.1_J,  DAX1_01_M01248_T,  SF1_Q6_M00727_T,  GTF3C5_2_H,  ESR1_MA0112.2_J,  NUR77_Q5_M01217_T,  SF1_Q6_01_M01132_T
32_re_2_0.472
TTTTAAAAA
0
33_e_332_0.527
GAACTGTGA
0
34_re_46_0.474
AATATATGC
0
35_e_52_0.525
ACAGCGTGG
0
36_re_21_0.476
CAGCACCTACA
0
37_re_0_0.476
TAAAATACGTA
0
38_re_76_0.477
AGTATTTAC
0
39_re_66_0.477
GACGTGTTTC
0
40_h_19_0.523
GATTGGCT
5 NFY_C_M00209_T,  CAAT_01_M00254_T,  CCAAT-box_POL004.1_J,  NFYA_MA0060.1_J,  NFY_01_M00287_T
41_re_7_0.477
GAAATGTATATT
0
42_re_78_0.478
AAACGTATGT
0
43_e_181_0.522
CCATCACGCC
0
44_e_303_0.521
ACTGCATTC
0
45_e_281_0.521
AGAGGTTTAC
0
46_e_359_0.521
AGGTTCAAC
0
47_h_30_0.520
GAGTGGAGTGGA
0
48_re_45_0.480
AGCACGTGGC
2 Myc_MA0147.1_J,  Mycn_MA0104.2_J
49_re_80_0.481
ACAGCCACAGG
0
50_re_67_0.482
CATAAACGC
1 CKMT1B_2_H
51_e_282_0.518
AATACGCTC
0
52_e_263_0.517
CAGATCTC
0
53_e_69_0.517
CCAACGTAGG
0
54_e_351_0.516
ACTGGGTA
0
55_e_406_0.516
CTCGTAGTC
0
56_e_62_0.514
GACACATCAC
0
57_e_242_0.513
CATACCTGAG
0
58_e_399_0.512
CACATCCTG
0
59_e_366_0.510
GAGTTCACA
0
60_e_203_0.510
GGAAGTCCA
0
61_e_284_0.509
CACATGGGAC
0
62_e_160_0.509
GATTCTACA
0
63_e_16_0.509
ATTCGAGTCC
0
64_e_355_0.507
AGACATGCC
1 P53_01_M00034_T
65_e_354_0.506
GAATAAGTC
0
66_e_34_0.505
ACCACCTGC
2 HLH-2_HLH-3_Cell09_U,  hlh-2::hlh-3_PL0002.1_J
67_e_401_0.505
CAGGCATAG
0
68_e_279_0.504
CCAGCGACA
1 BEN_02_M01241_T
69_e_261_0.503
ATCTTCACA
0
70_e_165_0.500
CAGCTGAGCA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 24

Matches to Query: 1_e_134_0.556

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Matches to Query: 2_re_30_0.447

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Matches to Query: 3_e_334_0.550

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Matches to Query: 4_re_65_0.452

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Matches to Query: 5_e_55_0.545

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Summary 

Alignment 

Name TAF9_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.66886e-05
E-value 0.0487473
q-value 0.0971627
Overlap 5
Offset -2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 6_re_40_0.455

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Summary 

Alignment 

Name Hbp1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.21272e-06
E-value 0.00646335
q-value 0.0129267
Overlap 9
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 7_re_43_0.456

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Matches to Query: 8_re_60_0.458

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Matches to Query: 9_e_176_0.542

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Matches to Query: 10_re_38_0.459

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Matches to Query: 11_e_345_0.540

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Summary 

Alignment 

Name YY1_02_M00069_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.85734e-07
E-value 0.000834629
q-value 0.00166926
Overlap 9
Offset 6
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name YY1_Q6_M00793_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.13967e-07
E-value 0.0026697
q-value 0.0026697
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 12_e_211_0.540

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Matches to Query: 13_re_19_0.460

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Matches to Query: 14_re_13_0.460

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Matches to Query: 15_re_71_0.461

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Matches to Query: 16_re_63_0.461

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Matches to Query: 17_re_48_0.461

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Matches to Query: 18_re_64_0.464

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Matches to Query: 19_e_259_0.536

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Matches to Query: 20_e_197_0.535

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Matches to Query: 21_e_100_0.535

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Matches to Query: 22_re_57_0.465

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Matches to Query: 23_e_249_0.534

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Matches to Query: 24_re_68_0.467

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Matches to Query: 25_e_309_0.532

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Matches to Query: 26_e_226_0.532

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Matches to Query: 27_re_28_0.469

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Matches to Query: 28_e_376_0.531

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Matches to Query: 29_re_82_0.470

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Matches to Query: 30_re_22_0.470

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Matches to Query: 31_re_56_0.471

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Summary 

Alignment 

Name ERR2_01_M01589_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.00881e-06
E-value 0.00294675
q-value 0.0040789
Overlap 10
Offset 0
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name NR4A2_MA0160.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.84027e-06
E-value 0.00537543
q-value 0.0040789
Overlap 8
Offset -2
Orientation Normal
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Summary 

Alignment 

Name DAX1_01_M01248_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.75732e-06
E-value 0.00805414
q-value 0.0040789
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name SF1_Q6_M00727_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.81011e-06
E-value 0.00820834
q-value 0.0040789
Overlap 8
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name GTF3C5_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.35912e-06
E-value 0.018575
q-value 0.00738425
Overlap 6
Offset -4
Orientation Reverse Complement
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Summary 

Alignment 

Name ESR1_MA0112.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.27889e-05
E-value 0.0373564
q-value 0.0107724
Overlap 10
Offset 2
Orientation Normal
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Summary 

Alignment 

Name NUR77_Q5_M01217_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.29876e-05
E-value 0.0379368
q-value 0.0107724
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name SF1_Q6_01_M01132_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.48611e-05
E-value 0.0434094
q-value 0.0107855
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 32_re_2_0.472

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Matches to Query: 33_e_332_0.527

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Matches to Query: 34_re_46_0.474

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Matches to Query: 35_e_52_0.525

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Matches to Query: 36_re_21_0.476

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Matches to Query: 37_re_0_0.476

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Matches to Query: 38_re_76_0.477

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Matches to Query: 39_re_66_0.477

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Matches to Query: 40_h_19_0.523

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Summary 

Alignment 

Name NFY_C_M00209_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.38647e-06
E-value 0.00697088
q-value 0.0139418
Overlap 8
Offset 3
Orientation Normal
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Summary 

Alignment 

Name CAAT_01_M00254_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.28466e-06
E-value 0.0212785
q-value 0.0141857
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name CCAAT-box_POL004.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.28466e-06
E-value 0.0212785
q-value 0.0141857
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name NFYA_MA0060.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.43194e-05
E-value 0.0418269
q-value 0.0175711
Overlap 8
Offset 5
Orientation Reverse Complement
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Summary 

Alignment 

Name NFY_01_M00287_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.70087e-05
E-value 0.0496824
q-value 0.0175711
Overlap 8
Offset 5
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 41_re_7_0.477

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Matches to Query: 42_re_78_0.478

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Matches to Query: 43_e_181_0.522

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Matches to Query: 44_e_303_0.521

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Matches to Query: 45_e_281_0.521

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Matches to Query: 46_e_359_0.521

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Matches to Query: 47_h_30_0.520

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Matches to Query: 48_re_45_0.480

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Summary 

Alignment 

Name Myc_MA0147.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.2872e-06
E-value 0.0154439
q-value 0.0252709
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.82419e-06
E-value 0.0257755
q-value 0.0252709
Overlap 10
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 49_re_80_0.481

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Matches to Query: 50_re_67_0.482

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Summary 

Alignment 

Name CKMT1B_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.36057e-07
E-value 0.000689522
q-value 0.00137904
Overlap 6
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 51_e_282_0.518

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Matches to Query: 52_e_263_0.517

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Matches to Query: 53_e_69_0.517

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Matches to Query: 54_e_351_0.516

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Matches to Query: 55_e_406_0.516

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Matches to Query: 56_e_62_0.514

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Matches to Query: 57_e_242_0.513

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Matches to Query: 58_e_399_0.512

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Matches to Query: 59_e_366_0.510

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Matches to Query: 60_e_203_0.510

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Matches to Query: 61_e_284_0.509

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Matches to Query: 62_e_160_0.509

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Matches to Query: 63_e_16_0.509

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Matches to Query: 64_e_355_0.507

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Summary 

Alignment 

Name P53_01_M00034_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50652e-05
E-value 0.0440053
q-value 0.0880106
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 65_e_354_0.506

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Matches to Query: 66_e_34_0.505

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Summary 

Alignment 

Name HLH-2_HLH-3_Cell09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.42879e-06
E-value 0.0187785
q-value 0.0209202
Overlap 9
Offset 3
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name hlh-2::hlh-3_PL0002.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.28141e-06
E-value 0.021269
q-value 0.0209202
Overlap 9
Offset 3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 67_e_401_0.505

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Matches to Query: 68_e_279_0.504

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Summary 

Alignment 

Name BEN_02_M01241_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.474e-06
E-value 0.0218316
q-value 0.0436631
Overlap 8
Offset -1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 69_e_261_0.503

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Matches to Query: 70_e_165_0.500

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 169.366 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.