TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

Next Top

Name 

Preview 

Matches 

List 

1_re_2_0.329
TCTCGAACTCC
1 RPC155_01_M01798_T
2_re_5_0.333
GTAATCCCAG
1 PITX2_Q2_M00482_T
3_re_62_0.346
AGGCTGAGG
0
4_re_28_0.347
ACCCCGTCTC
0
5_re_35_0.348
GGGTTTCACC
0
6_re_52_0.349
CGTGAGCCAC
0
7_re_44_0.350
AGGCGTGAG
0
8_re_30_0.353
CTGGGCAACAT
0
9_re_16_0.353
CGTGGTGGC
0
10_re_19_0.353
GAGAATCGCTT
0
11_re_0_0.356
ACGCCTGTA
0
12_re_18_0.359
CTCTACTAAA
0
13_re_31_0.360
CCGGGTTCAA
0
14_re_107_0.362
TACTAAAAA
2 MEF2C_01_M01773_T,  MEF2_04_M00233_T
15_re_26_0.362
AAAAATTAG
0
16_re_3_0.363
CCGAGATCGC
0
17_re_6_0.367
ATCGCGCCAC
0
18_re_24_0.371
CCAAAGTGCTGG
0
19_re_21_0.377
CCCGAGTAG
0
20_e_30_0.380
CCGCGACTA
0
21_re_80_0.384
GAGACCAGC
0
22_re_82_0.386
ACTGCACTC
0
23_re_25_0.395
GGCGACAGAGCGA
0
24_re_72_0.405
GATCCGCCC
0
25_h_1_0.594
CACAAAGGCC
1 SOX9_Q4_M01284_T
26_e_7_0.587
GTGCACACA
1 Zscan4_primary_SCI09_U
27_e_315_0.423
CCGATTCTC
0
28_e_58_0.571
CACATATGCC
0
29_h_10_0.565
CAGCGCTGAC
0
30_e_144_0.443
TGGACAGGAG
0
31_e_160_0.556
ACAGCAAGTG
0
32_e_107_0.449
CCCGGTAA
0
33_e_183_0.454
CGGTTCTTC
0
34_e_273_0.461
TAAGACGCG
0
35_e_277_0.467
ATACGAGT
0
36_e_185_0.530
CAGCCCCAC
1 YPR022C_01_M01647_T
37_e_82_0.528
CACCTCCAC
0
38_re_209_0.528
CCTCCTCTG
0
39_e_239_0.480
GTATCTCGC
0
40_e_104_0.507
TCGTTGTAT
0

Target Databases

Previous Next Top

Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 7

Matches to Query: 1_re_2_0.329

Previous Next Top

Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.42836e-07
E-value 0.00246192
q-value 0.00492385
Overlap 11
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 2_re_5_0.333

Previous Next Top

Summary 

Alignment 

Name PITX2_Q2_M00482_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.56526e-06
E-value 0.0133351
q-value 0.0266703
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 3_re_62_0.346

Previous Next Top

Matches to Query: 4_re_28_0.347

Previous Next Top

Matches to Query: 5_re_35_0.348

Previous Next Top

Matches to Query: 6_re_52_0.349

Previous Next Top

Matches to Query: 7_re_44_0.350

Previous Next Top

Matches to Query: 8_re_30_0.353

Previous Next Top

Matches to Query: 9_re_16_0.353

Previous Next Top

Matches to Query: 10_re_19_0.353

Previous Next Top

Matches to Query: 11_re_0_0.356

Previous Next Top

Matches to Query: 12_re_18_0.359

Previous Next Top

Matches to Query: 13_re_31_0.360

Previous Next Top

Matches to Query: 14_re_107_0.362

Previous Next Top

Summary 

Alignment 

Name MEF2C_01_M01773_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.82395e-06
E-value 0.00532777
q-value 0.00909997
Overlap 9
Offset 0
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name MEF2_04_M00233_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.11536e-06
E-value 0.00909997
q-value 0.00909997
Overlap 9
Offset 5
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 15_re_26_0.362

Previous Next Top

Matches to Query: 16_re_3_0.363

Previous Next Top

Matches to Query: 17_re_6_0.367

Previous Next Top

Matches to Query: 18_re_24_0.371

Previous Next Top

Matches to Query: 19_re_21_0.377

Previous Next Top

Matches to Query: 20_e_30_0.380

Previous Next Top

Matches to Query: 21_re_80_0.384

Previous Next Top

Matches to Query: 22_re_82_0.386

Previous Next Top

Matches to Query: 23_re_25_0.395

Previous Next Top

Matches to Query: 24_re_72_0.405

Previous Next Top

Matches to Query: 25_h_1_0.594

Previous Next Top

Summary 

Alignment 

Name SOX9_Q4_M01284_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.36729e-06
E-value 0.0156779
q-value 0.0312813
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 26_e_7_0.587

Previous Next Top

Summary 

Alignment 

Name Zscan4_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.04821e-06
E-value 0.0176668
q-value 0.0353336
Overlap 9
Offset 5
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 27_e_315_0.423

Previous Next Top

Matches to Query: 28_e_58_0.571

Previous Next Top

Matches to Query: 29_h_10_0.565

Previous Next Top

Matches to Query: 30_e_144_0.443

Previous Next Top

Matches to Query: 31_e_160_0.556

Previous Next Top

Matches to Query: 32_e_107_0.449

Previous Next Top

Matches to Query: 33_e_183_0.454

Previous Next Top

Matches to Query: 34_e_273_0.461

Previous Next Top

Matches to Query: 35_e_277_0.467

Previous Next Top

Matches to Query: 36_e_185_0.530

Previous Next Top

Summary 

Alignment 

Name YPR022C_01_M01647_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.69021e-06
E-value 0.0137001
q-value 0.0273493
Overlap 6
Offset -3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 37_e_82_0.528

Previous Next Top

Matches to Query: 38_re_209_0.528

Previous Next Top

Matches to Query: 39_e_239_0.480

Previous Next Top

Matches to Query: 40_e_104_0.507

Previous Next Top
Previous Next Top
TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 102.792 seconds
show model parameters...

Explanation of TOMTOM Results

Previous Top

The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.