TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_re_79_0.349
CTCACTGCACCC
1 Zbtb3_primary_SCI09_U
2_re_59_0.359
CCAAAGTGCTG
0
3_re_131_0.362
AGGCTGGTC
2 SMAP1L_4_H,  TRIM21_5_H
4_re_72_0.364
GCCTCCCAA
1 IK_Q5_M01169_T
5_re_158_0.367
AGGTCAGGA
0
6_re_27_0.369
ATTAGCCAG
0
7_re_115_0.371
GTGAGCCAC
0
8_h_2_0.628
CGCGCTGCGCGC
1 Zfp161_secondary_SCI09_U
9_re_57_0.377
GGAGTTCGAG
1 RPC155_01_M01798_T
10_re_52_0.379
ACTCGTGATC
0
11_re_55_0.385
CAGCTACTCC
0
12_re_7_0.386
AGTAGAGACG
0
13_re_83_0.390
CTCGGCTCA
0
14_re_99_0.392
ACAGAGCGAG
0
15_re_151_0.395
CAGGAGAATC
0
16_re_41_0.395
AACCCCGTC
0
17_e_55_0.599
CGACGTGCG
1 BZR1_01_M01156_T
18_re_175_0.403
GGTGACAGA
0
19_h_3_0.597
TGCGCCGA
0
20_h_15_0.588
GAAAGCGT
0
21_e_302_0.582
GTTTAACG
0
22_h_7_0.581
CGCCGGGAAAGT
0
23_h_24_0.569
AACGCGAATT
1 SWI4_01_M01609_T
24_e_356_0.568
AACGTCTA
0
25_e_253_0.567
AGAAAGCCG
0
26_re_130_0.563
CCCACGCG
1 HES5_7_H
27_re_54_0.538
CGCCCCCTC
3 SP1SP3_Q4_M01219_T,  Egr1_primary_SCI09_U,  Sp4_primary_SCI09_U
28_re_179_0.468
GATTGCGC
0
29_re_154_0.476
CGGACGTGA
0
30_e_362_0.519
GAGTTACCG
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 12

Matches to Query: 1_re_79_0.349

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Summary 

Alignment 

Name Zbtb3_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.43082e-05
E-value 0.0417943
q-value 0.0835887
Overlap 12
Offset 3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 2_re_59_0.359

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Matches to Query: 3_re_131_0.362

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Summary 

Alignment 

Name SMAP1L_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.49723e-06
E-value 0.0189784
q-value 0.0379568
Overlap 6
Offset -1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name TRIM21_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.67506e-05
E-value 0.0489286
q-value 0.0489286
Overlap 6
Offset -1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 4_re_72_0.364

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Summary 

Alignment 

Name IK_Q5_M01169_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.29206e-06
E-value 0.0066951
q-value 0.0133902
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 5_re_158_0.367

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Matches to Query: 6_re_27_0.369

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Matches to Query: 7_re_115_0.371

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Matches to Query: 8_h_2_0.628

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Summary 

Alignment 

Name Zfp161_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.67651e-06
E-value 0.0107391
q-value 0.0214782
Overlap 12
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 9_re_57_0.377

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.37942e-06
E-value 0.0157133
q-value 0.0314266
Overlap 10
Offset 3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 10_re_52_0.379

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Matches to Query: 11_re_55_0.385

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Matches to Query: 12_re_7_0.386

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Matches to Query: 13_re_83_0.390

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Matches to Query: 14_re_99_0.392

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Matches to Query: 15_re_151_0.395

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Matches to Query: 16_re_41_0.395

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Matches to Query: 17_e_55_0.599

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Summary 

Alignment 

Name BZR1_01_M01156_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.39358e-05
E-value 0.0407064
q-value 0.0812897
Overlap 6
Offset -3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 18_re_175_0.403

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Matches to Query: 19_h_3_0.597

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Matches to Query: 20_h_15_0.588

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Matches to Query: 21_e_302_0.582

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Matches to Query: 22_h_7_0.581

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Matches to Query: 23_h_24_0.569

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Summary 

Alignment 

Name SWI4_01_M01609_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.72491e-06
E-value 0.0225645
q-value 0.0451289
Overlap 7
Offset -1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 24_e_356_0.568

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Matches to Query: 25_e_253_0.567

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Matches to Query: 26_re_130_0.563

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Summary 

Alignment 

Name HES5_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.16244e-06
E-value 0.0267635
q-value 0.0318348
Overlap 6
Offset -2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 27_re_54_0.538

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Summary 

Alignment 

Name SP1SP3_Q4_M01219_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.38125e-06
E-value 0.00987664
q-value 0.0196452
Overlap 9
Offset 1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name Egr1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.51949e-05
E-value 0.0443842
q-value 0.0322397
Overlap 9
Offset 2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name Sp4_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.66468e-05
E-value 0.0486254
q-value 0.0322397
Overlap 9
Offset 5
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 28_re_179_0.468

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Matches to Query: 29_re_154_0.476

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Matches to Query: 30_e_362_0.519

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 73.696 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.