TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_h_8_0.595
TTTTCCGC
1 Sp100_primary_SCI09_U
2_h_26_0.592
GCGGCGAC
0
3_re_55_0.416
CCTGGCACA
0
4_e_37_0.583
ACGCCGAGA
0
5_e_13_0.583
CTCGCGAGA
0
6_e_202_0.580
AAATACGCA
0
7_re_50_0.421
CACACGTGA
0
8_re_5_0.425
ACGTGGCCT
0
9_re_6_0.426
CACGTGGCC
11 ABF1_02_M00400_T,  ABF_Q2_M00442_T,  GBF_Q2_M00441_T,  PIF3_01_M00434_T,  CG1_Q6_M00440_T,  PIF3_02_M00435_T,  GBP_Q6_M00182_T,  EMBP1_Q2_M00366_T,  ABF1_01_M00399_T,  CMYC_02_M01154_T
10_e_177_0.573
GGAAAAAAA
1 NFAT1_Q6_M01281_T
11_e_45_0.573
CAGCGACG
0
12_e_21_0.571
GCGGCCGGAC
0
13_e_36_0.571
AGGACCGCG
0
14_re_72_0.430
ACAGTGCCT
0
15_h_18_0.569
GCGGAGTTAA
0
16_e_355_0.568
CGTAATTAA
0
17_e_368_0.568
AACGATAC
0
18_h_6_0.567
CGCCGAACAA
0
19_re_3_0.434
CTCTGTGCCTT
0
20_e_329_0.565
ATTAACGAG
0
21_e_5_0.564
CGCCTGCGC
3 ZFP206_01_M01742_T,  HIST1H2BN_4_H,  TRIM69_7_H
22_re_61_0.438
AGATGAGGAC
0
23_re_19_0.438
AGCACCTACA
0
24_h_10_0.560
GCGTTGCTTT
0
25_re_35_0.440
GTGTGTGCA
0
26_re_48_0.440
CACGTGCTG
0
27_e_238_0.559
AACTACG
0
28_e_81_0.557
GCGCGTCTT
0
29_e_361_0.557
AAATAACGG
0
30_e_362_0.556
GGCATTTT
0
31_re_83_0.445
ACTGTGCTAG
0
32_re_57_0.446
CAGAGCTGGA
0
33_e_35_0.553
CGCGTTCCCA
0
34_e_83_0.551
ACGCGTCCC
0
35_h_21_0.550
CCGATTGT
0
36_e_370_0.550
AAACGGTTA
3 MYBPH3_01_M00218_T,  myb.Ph3_MA0054.1_J,  Kr_MA0452.1_J
37_e_65_0.549
TCAGCGGCT
0
38_re_51_0.452
GGGCAGGGAT
1 HLCS_2_H
39_re_66_0.454
TACCTCTCTG
0
40_e_171_0.543
GAAAGGAAAA
0
41_e_15_0.540
CCGGAGCCG
0
42_re_27_0.460
CTCAGTTTCT
0
43_re_49_0.462
CCTCCCCAC
1 MZF1_Q5_M01733_T
44_re_65_0.464
TGTGGCTGC
0
45_e_360_0.535
CGGTAAACA
2 FKH2_MA0297.1_J,  FOXO3_MA0157.1_J
46_e_99_0.531
CAGCCTCGC
0
47_re_78_0.484
CAGGTATTC
0
48_e_354_0.513
GGAATTCCA
0
49_h_4_0.512
CACATTCC
2 TEAD1_MA0090.1_J,  TEF_01_M01305_T
50_re_79_0.489
ACATGTAAAA
2 HMRA2_MA0318.1_J,  HMRA2_01_M01607_T

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 27

Matches to Query: 1_h_8_0.595

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Summary 

Alignment 

Name Sp100_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.42662e-05
E-value 0.0416716
q-value 0.0830307
Overlap 8
Offset 1
Orientation Reverse Complement
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Matches to Query: 2_h_26_0.592

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Matches to Query: 3_re_55_0.416

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Matches to Query: 4_e_37_0.583

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Matches to Query: 5_e_13_0.583

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Matches to Query: 6_e_202_0.580

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Matches to Query: 7_re_50_0.421

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Matches to Query: 8_re_5_0.425

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Matches to Query: 9_re_6_0.426

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Summary 

Alignment 

Name ABF1_02_M00400_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.78163e-08
E-value 0.000198091
q-value 0.000382237
Overlap 9
Offset 10
Orientation Normal
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Summary 

Alignment 

Name ABF_Q2_M00442_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.23945e-06
E-value 0.00362045
q-value 0.00254984
Overlap 9
Offset 5
Orientation Normal
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Summary 

Alignment 

Name GBF_Q2_M00441_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.35717e-06
E-value 0.0039643
q-value 0.00254984
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name PIF3_01_M00434_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.74432e-06
E-value 0.00801617
q-value 0.0030936
Overlap 9
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name CG1_Q6_M00440_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.74192e-06
E-value 0.0196932
q-value 0.00515658
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name PIF3_02_M00435_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.32074e-06
E-value 0.0213839
q-value 0.00515658
Overlap 9
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name GBP_Q6_M00182_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.30191e-06
E-value 0.0242499
q-value 0.00515658
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name EMBP1_Q2_M00366_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.69237e-06
E-value 0.0283114
q-value 0.00515658
Overlap 8
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name ABF1_01_M00399_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.30146e-05
E-value 0.0380157
q-value 0.00515658
Overlap 9
Offset 10
Orientation Normal
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Summary 

Alignment 

Name CMYC_02_M01154_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.32334e-05
E-value 0.0386547
q-value 0.00515658
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.40762e-05
E-value 0.0411167
q-value 0.00515658
Overlap 8
Offset 2
Orientation Normal
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Matches to Query: 10_e_177_0.573

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Summary 

Alignment 

Name NFAT1_Q6_M01281_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.61089e-06
E-value 0.0105474
q-value 0.0210448
Overlap 6
Offset 0
Orientation Normal
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Matches to Query: 11_e_45_0.573

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Matches to Query: 12_e_21_0.571

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Matches to Query: 13_e_36_0.571

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Matches to Query: 14_re_72_0.430

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Matches to Query: 15_h_18_0.569

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Matches to Query: 16_e_355_0.568

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Matches to Query: 17_e_368_0.568

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Matches to Query: 18_h_6_0.567

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Matches to Query: 19_re_3_0.434

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Matches to Query: 20_e_329_0.565

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Matches to Query: 21_e_5_0.564

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Summary 

Alignment 

Name ZFP206_01_M01742_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.22292e-07
E-value 0.00152561
q-value 0.00162183
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name HIST1H2BN_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.5523e-07
E-value 0.00162183
q-value 0.00162183
Overlap 9
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name TRIM69_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.31787e-06
E-value 0.00384951
q-value 0.00256634
Overlap 8
Offset 0
Orientation Reverse Complement
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Matches to Query: 22_re_61_0.438

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Matches to Query: 23_re_19_0.438

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Matches to Query: 24_h_10_0.560

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Matches to Query: 25_re_35_0.440

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Matches to Query: 26_re_48_0.440

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Matches to Query: 27_e_238_0.559

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Matches to Query: 28_e_81_0.557

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Matches to Query: 29_e_361_0.557

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Matches to Query: 30_e_362_0.556

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Matches to Query: 31_re_83_0.445

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Matches to Query: 32_re_57_0.446

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Matches to Query: 33_e_35_0.553

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Matches to Query: 34_e_83_0.551

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Matches to Query: 35_h_21_0.550

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Matches to Query: 36_e_370_0.550

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Summary 

Alignment 

Name MYBPH3_01_M00218_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.75343e-06
E-value 0.00512177
q-value 0.0102435
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name myb.Ph3_MA0054.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.41507e-06
E-value 0.0216594
q-value 0.0204281
Overlap 9
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Kr_MA0452.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.04903e-05
E-value 0.0306421
q-value 0.0204281
Overlap 9
Offset 2
Orientation Normal
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Matches to Query: 37_e_65_0.549

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Matches to Query: 38_re_51_0.452

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Summary 

Alignment 

Name HLCS_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.59597e-05
E-value 0.0466183
q-value 0.0930474
Overlap 5
Offset -1
Orientation Normal
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Matches to Query: 39_re_66_0.454

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Matches to Query: 40_e_171_0.543

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Matches to Query: 41_e_15_0.540

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Matches to Query: 42_re_27_0.460

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Matches to Query: 43_re_49_0.462

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Summary 

Alignment 

Name MZF1_Q5_M01733_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.03991e-06
E-value 0.0118006
q-value 0.023529
Overlap 7
Offset -1
Orientation Reverse Complement
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Matches to Query: 44_re_65_0.464

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Matches to Query: 45_e_360_0.535

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Summary 

Alignment 

Name FKH2_MA0297.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.0903e-07
E-value 0.00177898
q-value 0.00355135
Overlap 7
Offset -2
Orientation Normal
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Summary 

Alignment 

Name FOXO3_MA0157.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.38399e-05
E-value 0.0404264
q-value 0.0403513
Overlap 8
Offset -1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 46_e_99_0.531

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Matches to Query: 47_re_78_0.484

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Matches to Query: 48_e_354_0.513

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Matches to Query: 49_h_4_0.512

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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.15037e-06
E-value 0.00628122
q-value 0.00628122
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.15037e-06
E-value 0.00628122
q-value 0.00628122
Overlap 8
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 50_re_79_0.489

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Summary 

Alignment 

Name HMRA2_MA0318.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.92072e-06
E-value 0.0289784
q-value 0.0301255
Overlap 8
Offset -1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name HMRA2_01_M01607_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.2077e-05
E-value 0.0352768
q-value 0.0301255
Overlap 7
Offset -1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 111.322 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.