TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k36me3_5_0.593
GCGTGAGCC
0
2_e_k36me3_1_0.586
ACAGGCGTG
0
3_e_k36me3_13_0.582
CAGCCTGGCC
0
4_e_k36me3_56_0.574
GTGAGCCAC
0
5_e_k36me3_8_0.570
AGCCACCGC
0
6_e_k36me3_208_0.565
AGCTCGGCC
0
7_e_k36me3_356_0.564
CCATGCTGGT
0
8_e_k36me3_60_0.564
GGAGGATCACT
0
9_e_k36me3_133_0.563
GGCAACATAT
1 P4HB_2_H
10_e_k36me3_57_0.561
CACTGCAGC
0
11_e_k36me3_36_0.559
GACGTGGTGGT
0
12_e_k36me3_284_0.556
CACTACGA
0
13_e_k36me3_144_0.556
AACATGGCG
0
14_e_k27ac_11_0.447
AGAGAGAGAT
0
15_e_k36me3_30_0.553
ACGCCCAGC
0
16_e_k36me3_33_0.550
CTGCCCGCCT
0
17_e_k36me3_166_0.548
CTCAGGTGAG
3 sna_MA0086.1_J,  RAV1_02_M00344_T,  DELTAEF1_01_M00073_T
18_e_k4me3_54_0.547
ACGACGACG
0
19_h_k27me3_1_0.547
CCCGCGCG
6 RSC30_MA0375.1_J,  RSC3_MA0374.1_J,  SUT1_MA0399.1_J,  Rsc30_GR09_U,  SUT1_01_M01677_T,  RSC30_01_M01520_T
20_e_k36me3_75_0.547
AAGACGGTGTT
0
21_e_k36me3_330_0.546
GTACGATC
0
22_e_k36me3_105_0.542
GCAGCCTCC
0
23_e_k9me3_180_0.458
TCTCAGAAAG
0
24_e_k4me3_210_0.542
AAGTACCGG
0
25_h_k27me3_13_0.459
CTCCCCCGAATT
1 PDLIM5_8_H
26_e_k36me3_102_0.541
CCCGCGTA
0
27_e_k27me3_286_0.460
TCCCCAAATCCC
0
28_e_k36me3_253_0.539
AGTATCGT
0
29_e_k9me3_82_0.463
CAAATATCCA
0
30_h_k27me3_20_0.464
TTCCCTGGAAAG
1 NFAT2_02_M01749_T
31_e_k9me3_2_0.465
GGAATGGAA
0
32_e_k36me3_246_0.535
CACAGGCAT
0
33_e_k27me3_149_0.465
CCCCCTTTCC
0
34_h_k9me3_24_0.535
TTGTCTAGGCTC
0
35_e_k9me3_46_0.467
CAGAGTTGAG
0
36_e_k36me3_20_0.533
AGGCCACGC
1 Sp4_secondary_SCI09_U
37_e_k4me3_376_0.532
ATACGATA
1 ABF1_02_M01289_T
38_e_k4me3_32_0.532
CCGCGTCGC
0
39_h_k4me3_2_0.531
AACGTTAT
0
40_e_k4me3_357_0.531
ATAATCCG
0
41_e_k27me3_347_0.469
CACATTCTC
0
42_e_k4me3_287_0.530
CAGTTAACG
0
43_e_k27me3_81_0.471
CCTTCTCCCT
0
44_e_k9me3_170_0.471
ATTCTACAAA
0
45_e_k9me3_214_0.472
ATCATAGA
0
46_e_k36me3_138_0.528
CACGTAACC
2 BZIP911_01_M00358_T,  bZIP911_MA0097.1_J
47_e_k9me3_289_0.472
ATTTGGAGC
0
48_e_k9me3_304_0.473
ATTCATAGG
0
49_h_k4me3_38_0.474
CTTGCAGATT
0
50_e_k27me3_389_0.475
GAAGGGTT
0
51_e_k9me3_270_0.477
GTTGGAAAC
0
52_e_k36me3_328_0.522
CTGTAACA
0
53_e_k36me3_373_0.521
AGCACTTAC
0
54_e_k36me3_400_0.520
ACAGCTACC
0
55_e_k27ac_36_0.518
GACTCATGCT
1 BACH1_01_M00495_T
56_h_k9me3_19_0.483
GCAGACCC
0
57_h_k4me1_28_0.515
GTTAATAACA
0
58_e_k4me3_228_0.486
CGGAAAGAA
0
59_h_k9me3_12_0.492
CCATTGGC
0
60_e_k4me3_290_0.501
GCGTTAGG
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 17

Matches to Query: 1_e_k36me3_5_0.593

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Matches to Query: 2_e_k36me3_1_0.586

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Matches to Query: 3_e_k36me3_13_0.582

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Matches to Query: 4_e_k36me3_56_0.574

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Matches to Query: 5_e_k36me3_8_0.570

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Matches to Query: 6_e_k36me3_208_0.565

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Matches to Query: 7_e_k36me3_356_0.564

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Matches to Query: 8_e_k36me3_60_0.564

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Matches to Query: 9_e_k36me3_133_0.563

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Summary 

Alignment 

Name P4HB_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.35775e-05
E-value 0.0396598
q-value 0.0793197
Overlap 6
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 10_e_k36me3_57_0.561

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Matches to Query: 11_e_k36me3_36_0.559

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Matches to Query: 12_e_k36me3_284_0.556

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Matches to Query: 13_e_k36me3_144_0.556

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Matches to Query: 14_e_k27ac_11_0.447

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Matches to Query: 15_e_k36me3_30_0.553

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Matches to Query: 16_e_k36me3_33_0.550

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Matches to Query: 17_e_k36me3_166_0.548

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Summary 

Alignment 

Name sna_MA0086.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.57736e-06
E-value 0.00752846
q-value 0.0148888
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name RAV1_02_M00344_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.01174e-05
E-value 0.0295529
q-value 0.0271064
Overlap 10
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name DELTAEF1_01_M00073_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.40769e-05
E-value 0.0411187
q-value 0.0271064
Overlap 10
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 18_e_k4me3_54_0.547

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Matches to Query: 19_h_k27me3_1_0.547

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Summary 

Alignment 

Name RSC30_MA0375.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.37418e-06
E-value 0.00693498
q-value 0.0137702
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name RSC3_MA0374.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.99438e-06
E-value 0.0262726
q-value 0.0146567
Overlap 7
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name SUT1_MA0399.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.14301e-05
E-value 0.0333872
q-value 0.0146567
Overlap 7
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name Rsc30_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.28857e-05
E-value 0.0376391
q-value 0.0146567
Overlap 8
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name SUT1_01_M01677_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.43965e-05
E-value 0.0420521
q-value 0.0146567
Overlap 7
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name RSC30_01_M01520_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.51621e-05
E-value 0.0442886
q-value 0.0146567
Overlap 8
Offset 4
Orientation Reverse Complement
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Matches to Query: 20_e_k36me3_75_0.547

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Matches to Query: 21_e_k36me3_330_0.546

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Matches to Query: 22_e_k36me3_105_0.542

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Matches to Query: 23_e_k9me3_180_0.458

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Matches to Query: 24_e_k4me3_210_0.542

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Matches to Query: 25_h_k27me3_13_0.459

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Summary 

Alignment 

Name PDLIM5_8_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.32659e-05
E-value 0.0387498
q-value 0.0663807
Overlap 6
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 26_e_k36me3_102_0.541

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Matches to Query: 27_e_k27me3_286_0.460

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Matches to Query: 28_e_k36me3_253_0.539

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Matches to Query: 29_e_k9me3_82_0.463

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Matches to Query: 30_h_k27me3_20_0.464

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Summary 

Alignment 

Name NFAT2_02_M01749_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.24645e-06
E-value 0.0211669
q-value 0.042095
Overlap 11
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 31_e_k9me3_2_0.465

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Matches to Query: 32_e_k36me3_246_0.535

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Matches to Query: 33_e_k27me3_149_0.465

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Matches to Query: 34_h_k9me3_24_0.535

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Matches to Query: 35_e_k9me3_46_0.467

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Matches to Query: 36_e_k36me3_20_0.533

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Summary 

Alignment 

Name Sp4_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.09407e-05
E-value 0.0319578
q-value 0.0633013
Overlap 9
Offset 1
Orientation Reverse Complement
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Matches to Query: 37_e_k4me3_376_0.532

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Summary 

Alignment 

Name ABF1_02_M01289_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.49368e-05
E-value 0.0436304
q-value 0.0872608
Overlap 8
Offset 8
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 38_e_k4me3_32_0.532

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Matches to Query: 39_h_k4me3_2_0.531

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Matches to Query: 40_e_k4me3_357_0.531

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Matches to Query: 41_e_k27me3_347_0.469

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Matches to Query: 42_e_k4me3_287_0.530

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Matches to Query: 43_e_k27me3_81_0.471

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Matches to Query: 44_e_k9me3_170_0.471

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Matches to Query: 45_e_k9me3_214_0.472

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Matches to Query: 46_e_k36me3_138_0.528

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Summary 

Alignment 

Name BZIP911_01_M00358_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.81978e-06
E-value 0.0286836
q-value 0.0449154
Overlap 9
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name bZIP911_MA0097.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.56434e-05
E-value 0.0456943
q-value 0.0449154
Overlap 9
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 47_e_k9me3_289_0.472

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Matches to Query: 48_e_k9me3_304_0.473

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Matches to Query: 49_h_k4me3_38_0.474

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Matches to Query: 50_e_k27me3_389_0.475

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Matches to Query: 51_e_k9me3_270_0.477

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Matches to Query: 52_e_k36me3_328_0.522

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Matches to Query: 53_e_k36me3_373_0.521

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Matches to Query: 54_e_k36me3_400_0.520

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Matches to Query: 55_e_k27ac_36_0.518

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Summary 

Alignment 

Name BACH1_01_M00495_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.60871e-05
E-value 0.0469905
q-value 0.0526525
Overlap 10
Offset 5
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 56_h_k9me3_19_0.483

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Matches to Query: 57_h_k4me1_28_0.515

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Matches to Query: 58_e_k4me3_228_0.486

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Matches to Query: 59_h_k9me3_12_0.492

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Matches to Query: 60_e_k4me3_290_0.501

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 142.750 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.