TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_re_2_0.447
TTTTAAAAA
0
2_re_43_0.456
CTCCTTCCCA
0
3_re_30_0.458
AGGGGCAGGGAC
1 HLCS_2_H
4_re_41_0.459
GCCTGGCAC
0
5_re_3_0.459
TATTTTTAAC
2 AMEF2_Q6_M00403_T,  MEF2_05_M01301_T
6_re_14_0.459
TATAAAATA
0
7_re_5_0.460
AATAAATAT
1 CROC_01_M00266_T
8_re_24_0.463
AAATAAATG
1 CSTF2_5_H
9_re_23_0.463
AGAGAAGAGG
0
10_e_41_0.536
GCGCTCCAAC
0
11_re_57_0.465
CAGGCACTG
0
12_h_9_0.534
GAGTGGAATGGA
0
13_e_235_0.534
ACTGCATTC
0
14_re_63_0.466
CAGAGCTGGA
0
15_re_45_0.467
CGTATTTTA
0
16_re_18_0.467
CAGGAAACTG
0
17_re_90_0.468
CTCCCCACC
3 MZF1_01_M00083_T,  MZF1_Q5_M01733_T,  YPR022C_01_M01647_T
18_re_17_0.469
GGGAAAAAA
0
19_re_70_0.470
GAGAGGAAA
0
20_re_80_0.470
GAAATAATATA
0
21_re_12_0.472
TAATACGTAAA
0
22_e_186_0.528
GATACTACA
0
23_e_12_0.527
GAAACCCTAC
0
24_re_66_0.473
CTCTCTGCCT
0
25_re_20_0.473
CATTTTCTCT
0
26_h_16_0.525
ACATCACAAAGA
0
27_re_67_0.475
TACAGATGAGA
0
28_re_53_0.476
AATGAATGA
1 Hbp1_primary_SCI09_U
29_re_48_0.476
AACTGAGGC
0
30_e_107_0.524
TCTACAAAAA
0
31_h_3_0.524
CCTATGAATGTA
0
32_re_27_0.476
AGCACCTAC
0
33_e_49_0.523
GAATTCACAG
0
34_re_32_0.478
GGAAACGTAGG
2 DIS3_8_H,  NFAT1_Q6_M01281_T
35_h_4_0.519
GAATTCATAC
0
36_re_60_0.481
GGAGGACAGAG
0
37_e_60_0.519
TCGAGTACA
0
38_e_16_0.518
CCACATTCAT
0
39_re_93_0.482
ACGTAATAT
0
40_e_99_0.518
ATGTGAAGA
0
41_e_321_0.516
TACACGCA
0
42_e_149_0.515
GAACGTTCA
0
43_e_145_0.515
ACTCGTACAG
0
44_e_442_0.515
ACTGGCTGAA
0
45_h_29_0.514
TACCTGCA
0
46_e_108_0.514
AGCGCTTTG
0
47_e_3_0.514
AATTCGATG
0
48_e_178_0.514
AATGTAGCG
0
49_re_71_0.486
AGGTCACACA
1 GTF3C5_2_H
50_h_6_0.514
GTTCAACTCTGT
0
51_e_98_0.514
CATCAAATG
0
52_re_65_0.486
CACGTGGAG
0
53_re_19_0.487
AAGCACGTGGC
3 Myc_MA0147.1_J,  Mycn_MA0104.2_J,  MYC::MAX_MA0059.1_J
54_re_69_0.487
CACGGTCACA
0
55_e_241_0.513
CATGCATGCA
1 PF14_0633_PNAS08_U
56_re_29_0.488
AGCTGTGTG
0
57_e_92_0.512
ATACGATTC
0
58_e_225_0.512
GACGTGTCC
0
59_re_42_0.488
GAAACACACA
0
60_h_1_0.512
GCTTCTGTCTAG
0
61_e_62_0.512
CATCAGAGAG
0
62_e_221_0.512
AATCAAAAG
0
63_e_158_0.511
GCCTTATGA
0
64_re_85_0.489
AAATGTCAC
0
65_e_367_0.511
CGTCACTGC
0
66_h_2_0.511
GTGGGAAAGCCT
0
67_e_360_0.511
AGAGATGTG
0
68_e_90_0.510
AGATATTTCC
0
69_e_413_0.510
GACCGTATC
0
70_e_416_0.510
GGTACACAC
0
71_e_148_0.510
CATAAAAAC
1 ABDB_Q6_M01094_T
72_e_44_0.510
ATGATTCCA
0
73_e_24_0.510
GCAAGTGGAGTT
0
74_e_295_0.509
AATGCTGA
0
75_h_24_0.509
GTCTAGTTTT
0
76_e_203_0.508
GTGTACTCA
0
77_e_7_0.508
CACACTGGAC
0
78_e_169_0.507
CATTCTTTA
0
79_e_364_0.507
ACACATAG
0
80_h_5_0.507
AATGCGGGAA
0
81_e_121_0.507
CCGTTCCAC
0
82_e_198_0.507
AACTCATAC
0
83_e_188_0.506
CTACACGGC
0
84_e_368_0.506
GCGTGCCTT
0
85_h_23_0.506
GTGACGATAT
0
86_e_456_0.506
GTTTCTGGA
0
87_e_227_0.505
CAAGTACGC
0
88_e_399_0.505
GGTAGAAAA
0
89_e_370_0.505
AGGTGTACG
0
90_e_330_0.504
CTGTCACGC
0
91_e_440_0.504
GAAACAGTC
0
92_e_143_0.503
CAGAGTTGAG
0
93_e_176_0.503
AGGCACGTA
0
94_e_428_0.503
AATGACAGCA
1 PKNOX2_7_H
95_e_447_0.502
ACTGTGAAA
1 MRPL1_5_H
96_e_150_0.502
ACGTTATTC
0
97_e_215_0.502
ACAGCCACA
0
98_e_427_0.501
CCCTGCACA
0
99_e_66_0.501
ATTCCTTAC
0
100_h_8_0.501
AGCTGCAAGGGA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 19

Matches to Query: 1_re_2_0.447

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Matches to Query: 2_re_43_0.456

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Matches to Query: 3_re_30_0.458

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Summary 

Alignment 

Name HLCS_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.20819e-06
E-value 0.0122921
q-value 0.0245302
Overlap 5
Offset -3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 4_re_41_0.459

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Matches to Query: 5_re_3_0.459

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Summary 

Alignment 

Name AMEF2_Q6_M00403_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.06287e-06
E-value 0.0147886
q-value 0.0295427
Overlap 10
Offset 5
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name MEF2_05_M01301_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.64803e-05
E-value 0.048139
q-value 0.0418087
Overlap 9
Offset 3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 6_re_14_0.459

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Matches to Query: 7_re_5_0.460

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Summary 

Alignment 

Name CROC_01_M00266_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.33174e-06
E-value 0.012653
q-value 0.0251985
Overlap 9
Offset 3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 8_re_24_0.463

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Summary 

Alignment 

Name CSTF2_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.71188e-06
E-value 0.0196054
q-value 0.0391852
Overlap 7
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 9_re_23_0.463

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Matches to Query: 10_e_41_0.536

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Matches to Query: 11_re_57_0.465

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Matches to Query: 12_h_9_0.534

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Matches to Query: 13_e_235_0.534

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Matches to Query: 14_re_63_0.466

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Matches to Query: 15_re_45_0.467

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Matches to Query: 16_re_18_0.467

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Matches to Query: 17_re_90_0.468

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Summary 

Alignment 

Name MZF1_01_M00083_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.32834e-06
E-value 0.00680107
q-value 0.0135605
Overlap 8
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name MZF1_Q5_M01733_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.13397e-06
E-value 0.0149963
q-value 0.0149504
Overlap 7
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name YPR022C_01_M01647_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.67471e-05
E-value 0.0489182
q-value 0.0325123
Overlap 6
Offset -2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 18_re_17_0.469

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Matches to Query: 19_re_70_0.470

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Matches to Query: 20_re_80_0.470

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Matches to Query: 21_re_12_0.472

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Matches to Query: 22_e_186_0.528

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Matches to Query: 23_e_12_0.527

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Matches to Query: 24_re_66_0.473

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Matches to Query: 25_re_20_0.473

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Matches to Query: 26_h_16_0.525

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Matches to Query: 27_re_67_0.475

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Matches to Query: 28_re_53_0.476

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Summary 

Alignment 

Name Hbp1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.63747e-05
E-value 0.0478306
q-value 0.0954888
Overlap 9
Offset 6
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 29_re_48_0.476

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Matches to Query: 30_e_107_0.524

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Matches to Query: 31_h_3_0.524

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Matches to Query: 32_re_27_0.476

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Matches to Query: 33_e_49_0.523

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Matches to Query: 34_re_32_0.478

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Summary 

Alignment 

Name DIS3_8_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.31376e-07
E-value 0.00242845
q-value 0.00483368
Overlap 7
Offset 0
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name NFAT1_Q6_M01281_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.43706e-06
E-value 0.0188026
q-value 0.0187128
Overlap 6
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 35_h_4_0.519

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Matches to Query: 36_re_60_0.481

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Matches to Query: 37_e_60_0.519

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Matches to Query: 38_e_16_0.518

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Matches to Query: 39_re_93_0.482

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Matches to Query: 40_e_99_0.518

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Matches to Query: 41_e_321_0.516

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Matches to Query: 42_e_149_0.515

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Matches to Query: 43_e_145_0.515

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Matches to Query: 44_e_442_0.515

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Matches to Query: 45_h_29_0.514

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Matches to Query: 46_e_108_0.514

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Matches to Query: 47_e_3_0.514

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Matches to Query: 48_e_178_0.514

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Matches to Query: 49_re_71_0.486

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Summary 

Alignment 

Name GTF3C5_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.24386e-05
E-value 0.0363331
q-value 0.0724813
Overlap 6
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 50_h_6_0.514

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Matches to Query: 51_e_98_0.514

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Matches to Query: 52_re_65_0.486

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Matches to Query: 53_re_19_0.487

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Summary 

Alignment 

Name Myc_MA0147.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.79e-06
E-value 0.0110706
q-value 0.0139182
Overlap 10
Offset -1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name Mycn_MA0104.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.87026e-06
E-value 0.014226
q-value 0.0139182
Overlap 10
Offset -1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name MYC::MAX_MA0059.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.58261e-06
E-value 0.0279908
q-value 0.0182567
Overlap 11
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 54_re_69_0.487

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Matches to Query: 55_e_241_0.513

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Summary 

Alignment 

Name PF14_0633_PNAS08_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.92698e-06
E-value 0.0173127
q-value 0.0282636
Overlap 10
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 56_re_29_0.488

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Matches to Query: 57_e_92_0.512

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Matches to Query: 58_e_225_0.512

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Matches to Query: 59_re_42_0.488

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Matches to Query: 60_h_1_0.512

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Matches to Query: 61_e_62_0.512

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Matches to Query: 62_e_221_0.512

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Matches to Query: 63_e_158_0.511

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Matches to Query: 64_re_85_0.489

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Matches to Query: 65_e_367_0.511

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Matches to Query: 66_h_2_0.511

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Matches to Query: 67_e_360_0.511

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Matches to Query: 68_e_90_0.510

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Matches to Query: 69_e_413_0.510

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Matches to Query: 70_e_416_0.510

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Matches to Query: 71_e_148_0.510

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Summary 

Alignment 

Name ABDB_Q6_M01094_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.20817e-06
E-value 0.0210551
q-value 0.0421101
Overlap 7
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 72_e_44_0.510

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Matches to Query: 73_e_24_0.510

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Matches to Query: 74_e_295_0.509

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Matches to Query: 75_h_24_0.509

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Matches to Query: 76_e_203_0.508

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Matches to Query: 77_e_7_0.508

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Matches to Query: 78_e_169_0.507

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Matches to Query: 79_e_364_0.507

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Matches to Query: 80_h_5_0.507

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Matches to Query: 81_e_121_0.507

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Matches to Query: 82_e_198_0.507

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Matches to Query: 83_e_188_0.506

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Matches to Query: 84_e_368_0.506

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Matches to Query: 85_h_23_0.506

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Matches to Query: 86_e_456_0.506

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Matches to Query: 87_e_227_0.505

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Matches to Query: 88_e_399_0.505

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Matches to Query: 89_e_370_0.505

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Matches to Query: 90_e_330_0.504

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Matches to Query: 91_e_440_0.504

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Matches to Query: 92_e_143_0.503

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Matches to Query: 93_e_176_0.503

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Matches to Query: 94_e_428_0.503

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Summary 

Alignment 

Name PKNOX2_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.07932e-06
E-value 0.0265207
q-value 0.0529612
Overlap 6
Offset -3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 95_e_447_0.502

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Summary 

Alignment 

Name MRPL1_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.79138e-06
E-value 0.0139956
q-value 0.0279912
Overlap 8
Offset -1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 96_e_150_0.502

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Matches to Query: 97_e_215_0.502

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Matches to Query: 98_e_427_0.501

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Matches to Query: 99_e_66_0.501

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Matches to Query: 100_h_8_0.501

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 255.478 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.