TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_h_1_0.603
ATGACTCATTAA
14 GCN4_02_M01555_T,  GCN4_MA0303.1_J,  Gcn4_GR09_U,  Jundm2_secondary_SCI09_U,  AP1_C_M00199_T,  AP1_01_M00517_T,  Fos_MA0099.1_J,  GCN4_01_M00038_T,  AP1_Q6_01_M00925_T,  AP1_Q6_M00174_T
2_e_23_0.557
AATCTCGC
0
3_h_3_0.556
TTTCCGGT
18 ETS_class_MF0001.1_J,  ERG_01_M01752_T,  Elk4_EMBO10_U,  ELF2_10_H,  ELK1_MA0028.1_J,  ELK1_02_M00025_T,  Etv3_EMBO10_U,  Fli1_EMBO10_U,  Gm4881_EMBO10_U,  Etv6_EMBO10_U
4_e_0_0.552
CCGCCGCCG
1 ERF2_01_M01057_T
5_h_2_0.551
GCATTCCAGAGA
3 ABAA_01_M00027_T,  TEAD1_MA0090.1_J,  TEF_01_M01305_T
6_e_61_0.548
CGGCCTCGC
0
7_e_55_0.544
ACGCAGGCG
1 TRIM69_7_H
8_re_71_0.457
CACGTGGAG
0
9_e_199_0.543
AATCATTAA
3 HNF1_01_M00132_T,  HNF1_Q6_M00790_T,  HNF1A_MA0046.1_J
10_re_77_0.458
CCACACGTG
0
11_re_35_0.461
CACGTGGCAT
3 CG1_Q6_M00440_T,  GBF_Q2_M00441_T,  GBP_Q6_M00182_T
12_re_52_0.461
CCTGGCACA
0
13_e_79_0.538
GAGAACGCG
0
14_re_20_0.464
CAGCACCTACAT
0
15_re_39_0.467
GGGGCAGGGAT
0
16_re_58_0.469
CAGGCACTG
0
17_re_22_0.470
AGCACGTGGCTC
3 Myc_MA0147.1_J,  Mycn_MA0104.2_J,  CMYC_01_M01145_T
18_re_64_0.470
ATGCATATA
0
19_re_74_0.472
GGTCACACA
0
20_re_70_0.472
TACAGATGA
0
21_e_209_0.527
GAAACAAACG
0
22_e_37_0.527
CCCGGGAGCT
0
23_e_288_0.524
AAGGAATTCC
0
24_e_101_0.523
CAGGCTGGGC
0
25_re_48_0.478
AACTGAGGC
0
26_e_299_0.521
GAGGTTAAA
0
27_e_36_0.517
AGAGCGGCC
0
28_h_18_0.516
CTAAAGCAAAGC
0
29_e_261_0.503
TAACGGTGA
0
30_h_19_0.501
ATGACGTCATCG
15 VJUN_01_M00036_T,  Jundm2_primary_SCI09_U,  Atf1_primary_SCI09_U,  TGA2_01_M01586_T,  ATF1PCR1_01_M01600_T,  CREB1_MA0018.2_J,  CREB_Q4_01_M00917_T,  ATF3_Q6_M00513_T,  ATF_B_M00338_T,  STF1_02_M01187_T

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 61

Matches to Query: 1_h_1_0.603

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Summary 

Alignment 

Name GCN4_02_M01555_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.09319e-09
E-value 2.36402e-05
q-value 1.56658e-05
Overlap 12
Offset 6
Orientation Normal
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Summary 

Alignment 

Name GCN4_MA0303.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.09319e-09
E-value 2.36402e-05
q-value 1.56658e-05
Overlap 12
Offset 6
Orientation Normal
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Summary 

Alignment 

Name Gcn4_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.09319e-09
E-value 2.36402e-05
q-value 1.56658e-05
Overlap 12
Offset 6
Orientation Normal
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Summary 

Alignment 

Name Jundm2_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.57861e-08
E-value 0.000104531
q-value 2.96873e-05
Overlap 12
Offset 4
Orientation Normal
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Summary 

Alignment 

Name AP1_C_M00199_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.10117e-07
E-value 0.000321651
q-value 6.39451e-05
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name AP1_01_M00517_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.8967e-07
E-value 0.00113823
q-value 0.000205712
Overlap 11
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name Fos_MA0099.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.88474e-07
E-value 0.00171893
q-value 0.000284774
Overlap 8
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name GCN4_01_M00038_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.01469e-06
E-value 0.0029639
q-value 0.00042088
Overlap 12
Offset 9
Orientation Normal
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Summary 

Alignment 

Name AP1_Q6_01_M00925_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.31021e-06
E-value 0.00382712
q-value 0.000507229
Overlap 9
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name AP1_Q6_M00174_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.89989e-06
E-value 0.00554959
q-value 0.000648986
Overlap 10
Offset 1
Orientation Normal
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Summary 

Alignment 

Name AP1_Q4_01_M00926_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.09136e-06
E-value 0.00902987
q-value 0.000897582
Overlap 8
Offset -1
Orientation Normal
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Summary 

Alignment 

Name FRA1_Q5_M01267_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.66279e-06
E-value 0.010699
q-value 0.00101285
Overlap 8
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name AP1_MA0099.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.6352e-06
E-value 0.0164604
q-value 0.00142277
Overlap 7
Offset -1
Orientation Normal
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Summary 

Alignment 

Name AP1_Q2_01_M00924_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.63702e-05
E-value 0.0478174
q-value 0.00365625
Overlap 11
Offset -1
Orientation Normal
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Matches to Query: 2_e_23_0.557

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Matches to Query: 3_h_3_0.556

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Summary 

Alignment 

Name ETS_class_MF0001.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.44803e-07
E-value 0.00159137
q-value 0.00169347
Overlap 8
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name ERG_01_M01752_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.28768e-07
E-value 0.00212873
q-value 0.00169347
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name Elk4_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.36901e-06
E-value 0.00399887
q-value 0.00169347
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name ELF2_10_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.4275e-06
E-value 0.00416972
q-value 0.00169347
Overlap 7
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name ELK1_MA0028.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.97263e-06
E-value 0.00576206
q-value 0.00169347
Overlap 8
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name ELK1_02_M00025_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.55008e-06
E-value 0.00744878
q-value 0.00169347
Overlap 8
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name Etv3_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.66229e-06
E-value 0.00777655
q-value 0.00169347
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Fli1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.66229e-06
E-value 0.00777655
q-value 0.00169347
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Gm4881_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.66229e-06
E-value 0.00777655
q-value 0.00169347
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Etv6_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.9581e-06
E-value 0.0086406
q-value 0.00169347
Overlap 8
Offset 6
Orientation Normal
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Summary 

Alignment 

Name Erg_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.88066e-06
E-value 0.0142564
q-value 0.00254011
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Elf3_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.42264e-06
E-value 0.0158395
q-value 0.00258699
Overlap 8
Offset 6
Orientation Normal
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Summary 

Alignment 

Name Ets1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.4563e-06
E-value 0.0276219
q-value 0.00416432
Overlap 8
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Eip74EF_MA0026.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.14098e-05
E-value 0.033328
q-value 0.00447878
Overlap 7
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Etv4_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.20337e-05
E-value 0.0351505
q-value 0.00447878
Overlap 8
Offset 5
Orientation Normal
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Summary 

Alignment 

Name ELK4_MA0076.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.25174e-05
E-value 0.0365633
q-value 0.00447878
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name Ehf_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.33649e-05
E-value 0.0390388
q-value 0.00450071
Overlap 8
Offset 6
Orientation Normal
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Summary 

Alignment 

Name ETV4_13_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.54619e-05
E-value 0.0451643
q-value 0.00491765
Overlap 7
Offset 0
Orientation Reverse Complement
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Matches to Query: 4_e_0_0.552

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Summary 

Alignment 

Name ERF2_01_M01057_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.77273e-06
E-value 0.00517815
q-value 0.0102943
Overlap 7
Offset -1
Orientation Normal
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Matches to Query: 5_h_2_0.551

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Summary 

Alignment 

Name ABAA_01_M00027_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.90676e-06
E-value 0.00556965
q-value 0.0111301
Overlap 12
Offset 6
Orientation Normal
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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.27989e-05
E-value 0.0373855
q-value 0.0249031
Overlap 11
Offset 1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.27989e-05
E-value 0.0373855
q-value 0.0249031
Overlap 11
Offset 1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 6_e_61_0.548

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Matches to Query: 7_e_55_0.544

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Summary 

Alignment 

Name TRIM69_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.20428e-06
E-value 0.00351772
q-value 0.00703543
Overlap 8
Offset -1
Orientation Normal
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Matches to Query: 8_re_71_0.457

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Matches to Query: 9_e_199_0.543

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Summary 

Alignment 

Name HNF1_01_M00132_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.54217e-06
E-value 0.00742567
q-value 0.0142997
Overlap 9
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name HNF1_Q6_M00790_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.82686e-06
E-value 0.0199413
q-value 0.0192006
Overlap 9
Offset 6
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name HNF1A_MA0046.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.04527e-05
E-value 0.0305323
q-value 0.0195988
Overlap 9
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 10_re_77_0.458

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Matches to Query: 11_re_35_0.461

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Summary 

Alignment 

Name CG1_Q6_M00440_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.45653e-06
E-value 0.00717551
q-value 0.00902347
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name GBF_Q2_M00441_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.89973e-06
E-value 0.0113911
q-value 0.00902347
Overlap 9
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name GBP_Q6_M00182_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.23013e-05
E-value 0.035932
q-value 0.017431
Overlap 9
Offset 3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 12_re_52_0.461

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Matches to Query: 13_e_79_0.538

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Matches to Query: 14_re_20_0.464

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Matches to Query: 15_re_39_0.467

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Matches to Query: 16_re_58_0.469

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Matches to Query: 17_re_22_0.470

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Summary 

Alignment 

Name Myc_MA0147.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.37817e-06
E-value 0.0127886
q-value 0.019818
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.90557e-06
E-value 0.0201712
q-value 0.019818
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name CMYC_01_M01145_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.40925e-05
E-value 0.0411641
q-value 0.0269622
Overlap 11
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 18_re_64_0.470

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Matches to Query: 19_re_74_0.472

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Matches to Query: 20_re_70_0.472

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Matches to Query: 21_e_209_0.527

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Matches to Query: 22_e_37_0.527

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Matches to Query: 23_e_288_0.524

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Matches to Query: 24_e_101_0.523

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Matches to Query: 25_re_48_0.478

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Matches to Query: 26_e_299_0.521

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Matches to Query: 27_e_36_0.517

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Matches to Query: 28_h_18_0.516

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Matches to Query: 29_e_261_0.503

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Matches to Query: 30_h_19_0.501

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Summary 

Alignment 

Name VJUN_01_M00036_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.94506e-11
E-value 1.73655e-07
q-value 3.41571e-07
Overlap 12
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name Jundm2_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.77305e-10
E-value 1.10211e-06
q-value 1.08389e-06
Overlap 12
Offset 3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name Atf1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.07042e-08
E-value 3.12669e-05
q-value 1.53751e-05
Overlap 12
Offset 3
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name TGA2_01_M01586_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.69812e-08
E-value 0.000195652
q-value 6.41396e-05
Overlap 11
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name ATF1PCR1_01_M01600_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.26514e-07
E-value 0.000661649
q-value 0.000162679
Overlap 12
Offset 4
Orientation Normal
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Summary 

Alignment 

Name CREB1_MA0018.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.0022e-07
E-value 0.00175324
q-value 0.000344854
Overlap 8
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name CREB_Q4_01_M00917_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.45369e-07
E-value 0.00217722
q-value 0.000356873
Overlap 11
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name ATF3_Q6_M00513_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.83661e-07
E-value 0.00258117
q-value 0.000390541
Overlap 12
Offset 2
Orientation Normal
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Summary 

Alignment 

Name ATF_B_M00338_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.83615e-06
E-value 0.00536339
q-value 0.000753536
Overlap 12
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name STF1_02_M01187_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.40127e-06
E-value 0.0070141
q-value 0.000869414
Overlap 11
Offset 1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name CREBP1CJUN_01_M00041_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.28134e-06
E-value 0.00958478
q-value 0.000991503
Overlap 8
Offset -1
Orientation Normal
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Summary 

Alignment 

Name CREB_01_M00039_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.28134e-06
E-value 0.00958478
q-value 0.000991503
Overlap 8
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name STF1_01_M01186_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.69038e-06
E-value 0.0195426
q-value 0.00161915
Overlap 11
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name CREB_Q2_01_M00916_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.76356e-06
E-value 0.0197563
q-value 0.00161915
Overlap 12
Offset 1
Orientation Normal
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Summary 

Alignment 

Name bZIP_CREB/G-box-like_subclass_MF0002.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.42208e-05
E-value 0.0415391
q-value 0.00314251
Overlap 6
Offset -1
Orientation Normal
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 82.874 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.