TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_57_0.588
GGCCTCAAAG
0
2_e_78_0.577
GCATCAGCGT
0
3_e_315_0.576
CCAGGAGGG
0
4_e_114_0.569
TATGGTGAA
0
5_re_72_0.445
ACCTCTCTGG
0
6_e_74_0.555
GAAACCCTA
1 che-1_MA0260.1_J
7_e_188_0.553
GATGAACCC
0
8_re_65_0.448
CAGGCACTG
0
9_e_378_0.552
ATGCTGGGA
0
10_e_259_0.551
GTGCCGGGA
0
11_e_185_0.549
GCGTAGCG
0
12_e_5_0.549
AGCGCTTTGA
0
13_e_171_0.549
CCAAGATGGC
2 YY1_02_M00069_T,  YY1_Q6_M00793_T
14_e_183_0.549
ACTCACGCT
0
15_e_353_0.548
GACTGGGTA
0
16_re_17_0.452
GGAAGAAAAG
0
17_re_62_0.453
AGATGAGGAC
0
18_re_46_0.453
CTATGTGCC
0
19_re_26_0.455
CAGCACCTAC
0
20_re_75_0.457
CAAGGTCAC
3 ERR2_01_M01589_T,  NR4A2_MA0160.1_J,  SF1_Q6_M00727_T
21_e_58_0.538
AAAGGTTTAA
0
22_re_61_0.462
AATGAATGA
1 Hbp1_primary_SCI09_U
23_re_37_0.464
CATTTTCTCT
0
24_re_56_0.466
CACGTTTTA
0
25_re_96_0.466
TACAGATGA
0
26_e_310_0.533
CGGCCACCA
1 SKN7_02_M01638_T
27_re_67_0.468
AGCAGCAGC
0
28_e_4_0.531
CGTCGCTCA
0
29_re_97_0.469
GTCACGTAAT
0
30_e_37_0.530
CCGCCGCGG
1 ETF_Q6_M00695_T
31_re_105_0.471
ACTACCTGC
0
32_e_112_0.526
ACTAATACA
0
33_e_79_0.525
AGTTTTTATT
0
34_re_38_0.477
ATCACAGAGAA
0
35_e_67_0.522
AAAACTAGAC
0
36_h_21_0.521
TTCTTTTGAT
0
37_h_22_0.513
GGGTCCCC
0
38_e_168_0.512
AGACATGCC
1 P53_01_M00034_T
39_e_376_0.505
GCTGTGTCA
0
40_h_4_0.504
CCGAATAGGAAC
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 10

Matches to Query: 1_e_57_0.588

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Matches to Query: 2_e_78_0.577

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Matches to Query: 3_e_315_0.576

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Matches to Query: 4_e_114_0.569

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Matches to Query: 5_re_72_0.445

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Matches to Query: 6_e_74_0.555

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Summary 

Alignment 

Name che-1_MA0260.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.427e-05
E-value 0.0416827
q-value 0.0833653
Overlap 6
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 7_e_188_0.553

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Matches to Query: 8_re_65_0.448

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Matches to Query: 9_e_378_0.552

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Matches to Query: 10_e_259_0.551

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Matches to Query: 11_e_185_0.549

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Matches to Query: 12_e_5_0.549

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Matches to Query: 13_e_171_0.549

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Summary 

Alignment 

Name YY1_02_M00069_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.31837e-07
E-value 0.00126139
q-value 0.00252279
Overlap 10
Offset 5
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name YY1_Q6_M00793_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.44923e-06
E-value 0.0071542
q-value 0.0071542
Overlap 9
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 14_e_183_0.549

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Matches to Query: 15_e_353_0.548

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Matches to Query: 16_re_17_0.452

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Matches to Query: 17_re_62_0.453

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Matches to Query: 18_re_46_0.453

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Matches to Query: 19_re_26_0.455

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Matches to Query: 20_re_75_0.457

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Summary 

Alignment 

Name ERR2_01_M01589_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.28595e-06
E-value 0.00375626
q-value 0.00521266
Overlap 9
Offset 1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name NR4A2_MA0160.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.79654e-06
E-value 0.00524768
q-value 0.00521266
Overlap 8
Offset -1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name SF1_Q6_M00727_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.23411e-06
E-value 0.0182098
q-value 0.0120589
Overlap 8
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 21_e_58_0.538

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Matches to Query: 22_re_61_0.462

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Summary 

Alignment 

Name Hbp1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.48733e-05
E-value 0.043445
q-value 0.0867636
Overlap 9
Offset 6
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 23_re_37_0.464

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Matches to Query: 24_re_56_0.466

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Matches to Query: 25_re_96_0.466

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Matches to Query: 26_e_310_0.533

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Summary 

Alignment 

Name SKN7_02_M01638_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.6101e-06
E-value 0.0280711
q-value 0.0561246
Overlap 5
Offset -1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 27_re_67_0.468

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Matches to Query: 28_e_4_0.531

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Matches to Query: 29_re_97_0.469

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Matches to Query: 30_e_37_0.530

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Summary 

Alignment 

Name ETF_Q6_M00695_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.96703e-06
E-value 0.00866668
q-value 0.0172386
Overlap 7
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 31_re_105_0.471

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Matches to Query: 32_e_112_0.526

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Matches to Query: 33_e_79_0.525

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Matches to Query: 34_re_38_0.477

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Matches to Query: 35_e_67_0.522

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Matches to Query: 36_h_21_0.521

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Matches to Query: 37_h_22_0.513

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Matches to Query: 38_e_168_0.512

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Summary 

Alignment 

Name P53_01_M00034_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.25298e-06
E-value 0.012423
q-value 0.0248459
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 39_e_376_0.505

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Matches to Query: 40_h_4_0.504

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 97.241 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.