TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k9me3-h1_0.581
CATGTTGGCT
0
2_e_k9me3-h1_0.578
AGTTCGAGA
0
3_e_k9me3-h1_0.577
CCGGGTTCA
0
4_e_k9me3-h1_0.575
AGGCTGAGG
0
5_e_k9me3-h1_0.566
GCAGTGAGC
0
6_e_k9me3-h1_0.565
CCTCCCAAAT
2 IK_Q5_M01169_T,  LYF1_01_M00141_T
7_e_k9me3-tro_0.564
CAGGGAAGAG
0
8_e_k9me3-h1_0.563
CCATTGCAC
0
9_e_k9me3-h1_0.563
GGCGGATCA
0
10_e_k9me3-h1_0.562
ACGCCCGGCCC
0
11_h_k9me3-tro_0.561
GGTTCTGCGG
0
12_e_k9me3-h1_0.561
CTCGTGATCG
0
13_e_k9me3-h1_0.560
CCCGCCACCACA
1 ING4_01_M01743_T
14_e_k9me3-h1_0.558
CCGTCTCTA
0
15_e_k9me3-h1_0.558
GACGGGTGA
0
16_e_k9me3-h1_0.556
AGGTGTGAGCAC
1 TBX5_Q5_M01044_T
17_h_k9me3-tro_0.555
AAGGACCC
0
18_e_k9me3-h1_0.555
ATCACTTGA
0
19_h_k9me3-tro_0.554
CTTCCAACAACA
1 GAMYB_Q2_M01135_T
20_h_k9me3-h1_0.553
GTCTACAGCTCC
0
21_e_k9me3-h1_0.552
GCAGGAGAA
0
22_e_k9me3-tro_0.551
AAAGCCTTC
0
23_h_k9me3-tro_0.551
GGAACTGT
0
24_e_k9me3-tro_0.551
CTTGCCTGC
0
25_e_k9me3-h1_0.550
CGCACTCGG
0
26_h_k9me3-tro_0.550
TTCCTGCGCA
0
27_e_k9me3-h1_0.549
AGTGGGTGC
0
28_e_k9me3-tro_0.549
CAGGCAGTCT
0
29_e_k9me3-tro_0.549
CTGCACAGAA
0
30_e_k9me3-tro_0.549
GAAACTTACC
0
31_h_k9me3-h1_0.546
AAGATGGCCGAA
2 NFMUE1_Q6_M00651_T,  YY1_02_M00069_T
32_e_k9me3-h1_0.545
GGCGAGCCG
0
33_e_k9me3-tro_0.544
AGCAGCTGC
6 Ascl2_primary_SCI09_U,  NEUROD_01_M01287_T,  MYF_01_M01302_T,  Myf_MA0055.1_J,  LBP1_Q6_M00644_T,  NHLH1_MA0048.1_J
34_e_k9me3-h1_0.543
ACCTGCCTC
0
35_e_k9me3-tro_0.542
AGCAGAGAA
0
36_e_k9me3-tro_0.542
GAGAAGCCAC
0
37_e_k9me3-tro_0.542
GGTAATTTAT
0
38_h_k9me3-h1_0.541
AATGCAGACATC
0
39_e_k9me3-tro_0.540
GACATTTGC
0
40_h_k9me3-tro_0.540
TTGACCGG
0
41_e_k9me3-tro_0.540
TAGAAGCAA
0
42_e_k9me3-tro_0.539
ATTGTGAGG
0
43_e_k9me3-h1_0.539
GAGATGAAC
0
44_e_k9me3-tro_0.539
ACAGGACAT
0
45_e_k9me3-tro_0.538
TGACTTTG
0
46_e_k9me3-h1_0.538
GACGGACG
0
47_e_k9me3-h1_0.538
CAAACGTGAC
0
48_h_k9me3-tro_0.538
GACACAGCCA
0
49_e_k9me3-tro_0.535
GAAAGCCAAG
0
50_e_k9me3-tro_0.534
AAACAACG
0
51_e_k9me3-h1_0.534
CGCCGCGCC
2 ODC1_3_H,  CNOT3_01_M01253_T
52_e_k9me3-tro_0.534
CAGGGCCAG
0
53_h_k9me3-tro_0.534
TTTATCAAGACA
0
54_e_k9me3-tro_0.533
GCTGCAGCA
0
55_e_k9me3-tro_0.532
CATGGCAGC
1 DIABLO_7_H
56_e_k9me3-tro_0.532
ACACGGGTC
0
57_e_k9me3-tro_0.532
CACGTGTCAG
2 HAC1_MA0310.1_J,  CBF1_02_M01699_T
58_e_k9me3-tro_0.531
AGTTTCTCCC
0
59_e_k9me3-tro_0.530
CCATGTAAG
0
60_e_k9me3-tro_0.530
CAGAGAAAG
0
61_e_k9me3-tro_0.529
CAGATGTGCC
0
62_e_k9me3-tro_0.529
CCCGTAATT
0
63_e_k9me3-tro_0.529
ACAGTGTGG
0
64_h_k9me3-tro_0.528
CACTGAGACA
0
65_h_k9me3-tro_0.528
GTTGCAAC
0
66_e_k9me3-tro_0.528
CCAGGGCTC
1 PIK3C3_3_H
67_e_k9me3-tro_0.527
CGCTGCTGA
1 MAFA_Q4_01_M01709_T
68_e_k9me3-h1_0.526
TGCTAGGA
0
69_e_k9me3-h1_0.524
ATTTCCAACA
4 MAGED4_4_H,  MYLK_6_H,  NFATC3_14_H,  NFATC4_10_H
70_e_k9me3-h1_0.524
CCGAATAGGA
0
71_e_k9me3-tro_0.524
GATTGTGAC
0
72_e_k9me3-tro_0.523
TAAACGGCA
0
73_e_k9me3-tro_0.522
GTCTCGGCA
0
74_e_k9me3-tro_0.522
CAGTATCTC
0
75_e_k9me3-tro_0.522
ACTCAGATA
0
76_e_k9me3-h1_0.521
CAGAAGACGG
0
77_e_k9me3-h1_0.521
CCCTAATACA
1 RGM1_01_M01627_T
78_e_k9me3-tro_0.520
GCTGTAAAA
0
79_e_k9me3-h1_0.520
GCAGTATTA
0
80_e_k9me3-tro_0.520
ACGTGAACA
0
81_e_k9me3-h1_0.519
CACTCCCTA
0
82_h_k9me3-h1_0.519
CTGCTTCGGCTC
0
83_e_k9me3-h1_0.519
AACCTCCACAC
0
84_h_k9me3-tro_0.519
CCGGCGGA
0
85_e_k9me3-h1_0.518
CGTAGTGT
0
86_e_k9me3-tro_0.516
CAGCGCAT
0
87_e_k9me3-tro_0.515
CAGGTGGGC
0
88_h_k9me3-h1_0.514
AGGAGATTATAT
0
89_e_k9me3-tro_0.512
CTAAGCGT
0
90_e_k9me3-tro_0.511
TAAAACCAG
0
91_e_k9me3-h1_0.511
ACAATCCCC
0
92_e_k9me3-h1_0.511
CCACGTAAA
0
93_e_k9me3-tro_0.511
GAAAACCC
0
94_e_k9me3-h1_0.510
CTTATGAGA
0
95_e_k9me3-tro_0.508
CCTTCTTGC
0
96_e_k9me3-h1_0.507
TATCGGG
0
97_e_k9me3-h1_0.506
ATCCGTAAA
0
98_e_k9me3-h1_0.505
GGCGCTGCC
0
99_e_k9me3-h1_0.505
AATCATGGG
0
100_h_k9me3-h1_0.504
GCATTAGATT
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 25

Matches to Query: 1_e_k9me3-h1_0.581

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Matches to Query: 2_e_k9me3-h1_0.578

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Matches to Query: 3_e_k9me3-h1_0.577

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Matches to Query: 4_e_k9me3-h1_0.575

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Matches to Query: 5_e_k9me3-h1_0.566

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Matches to Query: 6_e_k9me3-h1_0.565

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Summary 

Alignment 

Name IK_Q5_M01169_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.08458e-07
E-value 0.00265361
q-value 0.00411469
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name LYF1_01_M00141_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.41006e-06
E-value 0.00411879
q-value 0.00411469
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 7_e_k9me3-tro_0.564

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Matches to Query: 8_e_k9me3-h1_0.563

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Matches to Query: 9_e_k9me3-h1_0.563

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Matches to Query: 10_e_k9me3-h1_0.562

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Matches to Query: 11_h_k9me3-tro_0.561

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Matches to Query: 12_e_k9me3-h1_0.561

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Matches to Query: 13_e_k9me3-h1_0.560

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Summary 

Alignment 

Name ING4_01_M01743_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.45698e-07
E-value 0.00130188
q-value 0.0025958
Overlap 6
Offset -4
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 14_e_k9me3-h1_0.558

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Matches to Query: 15_e_k9me3-h1_0.558

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Matches to Query: 16_e_k9me3-h1_0.556

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Summary 

Alignment 

Name TBX5_Q5_M01044_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.4842e-07
E-value 0.00277033
q-value 0.00554067
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 17_h_k9me3-tro_0.555

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Matches to Query: 18_e_k9me3-h1_0.555

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Matches to Query: 19_h_k9me3-tro_0.554

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Summary 

Alignment 

Name GAMYB_Q2_M01135_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.09548e-06
E-value 0.0236469
q-value 0.0472938
Overlap 11
Offset -1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 20_h_k9me3-h1_0.553

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Matches to Query: 21_e_k9me3-h1_0.552

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Matches to Query: 22_e_k9me3-tro_0.551

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Matches to Query: 23_h_k9me3-tro_0.551

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Matches to Query: 24_e_k9me3-tro_0.551

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Matches to Query: 25_e_k9me3-h1_0.550

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Matches to Query: 26_h_k9me3-tro_0.550

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Matches to Query: 27_e_k9me3-h1_0.549

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Matches to Query: 28_e_k9me3-tro_0.549

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Matches to Query: 29_e_k9me3-tro_0.549

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Matches to Query: 30_e_k9me3-tro_0.549

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Matches to Query: 31_h_k9me3-h1_0.546

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Summary 

Alignment 

Name NFMUE1_Q6_M00651_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.03676e-07
E-value 0.000302838
q-value 0.000605675
Overlap 9
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name YY1_02_M00069_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.23463e-06
E-value 0.0240534
q-value 0.0240534
Overlap 12
Offset 7
Orientation Reverse Complement
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Matches to Query: 32_e_k9me3-h1_0.545

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Matches to Query: 33_e_k9me3-tro_0.544

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Summary 

Alignment 

Name Ascl2_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.26502e-06
E-value 0.00369513
q-value 0.00603211
Overlap 9
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name NEUROD_01_M01287_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.36594e-06
E-value 0.0156739
q-value 0.00611854
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name MYF_01_M01302_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.33172e-06
E-value 0.018495
q-value 0.00611854
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name Myf_MA0055.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.33172e-06
E-value 0.018495
q-value 0.00611854
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name LBP1_Q6_M00644_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.29866e-06
E-value 0.0271614
q-value 0.00770193
Overlap 7
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name NHLH1_MA0048.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.61975e-05
E-value 0.0473129
q-value 0.0117391
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 34_e_k9me3-h1_0.543

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Matches to Query: 35_e_k9me3-tro_0.542

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Matches to Query: 36_e_k9me3-tro_0.542

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Matches to Query: 37_e_k9me3-tro_0.542

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Matches to Query: 38_h_k9me3-h1_0.541

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Matches to Query: 39_e_k9me3-tro_0.540

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Matches to Query: 40_h_k9me3-tro_0.540

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Matches to Query: 41_e_k9me3-tro_0.540

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Matches to Query: 42_e_k9me3-tro_0.539

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Matches to Query: 43_e_k9me3-h1_0.539

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Matches to Query: 44_e_k9me3-tro_0.539

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Matches to Query: 45_e_k9me3-tro_0.538

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Matches to Query: 46_e_k9me3-h1_0.538

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Matches to Query: 47_e_k9me3-h1_0.538

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Matches to Query: 48_h_k9me3-tro_0.538

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Matches to Query: 49_e_k9me3-tro_0.535

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Matches to Query: 50_e_k9me3-tro_0.534

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Matches to Query: 51_e_k9me3-h1_0.534

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Summary 

Alignment 

Name ODC1_3_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.24714e-05
E-value 0.0364289
q-value 0.0371578
Overlap 6
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name CNOT3_01_M01253_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.27909e-05
E-value 0.0373621
q-value 0.0371578
Overlap 9
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 52_e_k9me3-tro_0.534

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Matches to Query: 53_h_k9me3-tro_0.534

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Matches to Query: 54_e_k9me3-tro_0.533

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Matches to Query: 55_e_k9me3-tro_0.532

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Summary 

Alignment 

Name DIABLO_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.46374e-05
E-value 0.0427558
q-value 0.0612284
Overlap 7
Offset -2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 56_e_k9me3-tro_0.532

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Matches to Query: 57_e_k9me3-tro_0.532

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Summary 

Alignment 

Name HAC1_MA0310.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.64174e-06
E-value 0.0281635
q-value 0.0187381
Overlap 8
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name CBF1_02_M01699_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.84644e-06
E-value 0.0287615
q-value 0.0187381
Overlap 6
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 58_e_k9me3-tro_0.531

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Matches to Query: 59_e_k9me3-tro_0.530

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Matches to Query: 60_e_k9me3-tro_0.530

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Matches to Query: 61_e_k9me3-tro_0.529

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Matches to Query: 62_e_k9me3-tro_0.529

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Matches to Query: 63_e_k9me3-tro_0.529

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Matches to Query: 64_h_k9me3-tro_0.528

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Matches to Query: 65_h_k9me3-tro_0.528

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Matches to Query: 66_e_k9me3-tro_0.528

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Summary 

Alignment 

Name PIK3C3_3_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.61224e-07
E-value 0.00134723
q-value 0.00269447
Overlap 6
Offset -3
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 67_e_k9me3-tro_0.527

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Summary 

Alignment 

Name MAFA_Q4_01_M01709_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.88565e-06
E-value 0.00842897
q-value 0.0168579
Overlap 7
Offset -2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 68_e_k9me3-h1_0.526

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Matches to Query: 69_e_k9me3-h1_0.524

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Summary 

Alignment 

Name MAGED4_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.9137e-07
E-value 0.000851091
q-value 0.001692
Overlap 6
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name MYLK_6_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.01631e-06
E-value 0.0204947
q-value 0.020372
Overlap 6
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name NFATC3_14_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.20622e-05
E-value 0.0352338
q-value 0.0223312
Overlap 6
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name NFATC4_10_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.53821e-05
E-value 0.0449313
q-value 0.0223312
Overlap 6
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 70_e_k9me3-h1_0.524

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Matches to Query: 71_e_k9me3-tro_0.524

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Matches to Query: 72_e_k9me3-tro_0.523

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Matches to Query: 73_e_k9me3-tro_0.522

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Matches to Query: 74_e_k9me3-tro_0.522

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Matches to Query: 75_e_k9me3-tro_0.522

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Matches to Query: 76_e_k9me3-h1_0.521

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Matches to Query: 77_e_k9me3-h1_0.521

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Summary 

Alignment 

Name RGM1_01_M01627_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.1367e-05
E-value 0.0332031
q-value 0.0664063
Overlap 4
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 78_e_k9me3-tro_0.520

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Matches to Query: 79_e_k9me3-h1_0.520

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Matches to Query: 80_e_k9me3-tro_0.520

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Matches to Query: 81_e_k9me3-h1_0.519

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Matches to Query: 82_h_k9me3-h1_0.519

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Matches to Query: 83_e_k9me3-h1_0.519

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Matches to Query: 84_h_k9me3-tro_0.519

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Matches to Query: 85_e_k9me3-h1_0.518

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Matches to Query: 86_e_k9me3-tro_0.516

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Matches to Query: 87_e_k9me3-tro_0.515

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Matches to Query: 88_h_k9me3-h1_0.514

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Matches to Query: 89_e_k9me3-tro_0.512

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Matches to Query: 90_e_k9me3-tro_0.511

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Matches to Query: 91_e_k9me3-h1_0.511

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Matches to Query: 92_e_k9me3-h1_0.511

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Matches to Query: 93_e_k9me3-tro_0.511

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Matches to Query: 94_e_k9me3-h1_0.510

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Matches to Query: 95_e_k9me3-tro_0.508

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Matches to Query: 96_e_k9me3-h1_0.507

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Matches to Query: 97_e_k9me3-h1_0.506

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Matches to Query: 98_e_k9me3-h1_0.505

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Matches to Query: 99_e_k9me3-h1_0.505

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Matches to Query: 100_h_k9me3-h1_0.504

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 231.089 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.