TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k9me3-h1_0.593
GTGAGATGA
0
2_e_k9me3-npc_0.587
CAGCAACAGGA
1 RAV1_01_M00343_T
3_e_k9me3-npc_0.583
AGCTGCACA
0
4_e_k9me3-npc_0.581
CTGTTAAA
0
5_e_k9me3-h1_0.574
CTCAAACTC
0
6_h_k9me3-npc_0.570
GCATCTAAAG
0
7_h_k9me3-npc_0.569
AGGTCCAGAACC
0
8_e_k9me3-h1_0.568
CACTCCAGC
0
9_e_k9me3-npc_0.567
GGAAGTACAG
0
10_e_k9me3-h1_0.566
ACAGGCATG
0
11_e_k9me3-npc_0.565
GACTAATACT
0
12_e_k9me3-npc_0.564
GTTTGGAGA
0
13_e_k9me3-h1_0.564
CCGTCCAT
0
14_e_k9me3-h1_0.563
ACTCTGTCT
0
15_h_k9me3-npc_0.563
GCTGGTGCTGTT
0
16_e_k9me3-npc_0.561
ACGCTTCAT
0
17_e_k9me3-h1_0.561
CCTGGGTGAGA
0
18_h_k9me3-npc_0.560
ATTGTGTTCT
0
19_e_k9me3-npc_0.560
AACAGTTAC
0
20_e_k9me3-npc_0.560
CTGTTGTGAT
0
21_e_k9me3-npc_0.559
CTCAGTTTCT
0
22_e_k9me3-h1_0.559
TAGGGGTCAG
0
23_e_k9me3-h1_0.558
ATATGTATG
0
24_h_k9me3-npc_0.557
GGTGCTGCAGCA
0
25_e_k9me3-npc_0.557
CGTTTACCC
0
26_e_k9me3-h1_0.557
GAGGGCTCCC
0
27_e_k9me3-h1_0.557
GAGACCAGC
0
28_h_k9me3-npc_0.557
CACACAAC
0
29_e_k9me3-npc_0.556
TTAACCGCAG
0
30_e_k9me3-h1_0.556
CTGACCTCA
1 TERALPHA_Q6_M01724_T
31_e_k9me3-npc_0.555
GGAAGAGTA
0
32_e_k9me3-npc_0.555
ACATCACTGCC
0
33_e_k9me3-h1_0.555
GAGCCATG
0
34_e_k9me3-npc_0.554
ACAACGAG
0
35_e_k9me3-h1_0.553
GAGTCTTGCT
0
36_e_k9me3-h1_0.552
AGAGACGGG
0
37_e_k9me3-npc_0.552
CCAAGAACA
0
38_e_k9me3-h1_0.552
GTGGAAGGA
0
39_e_k9me3-npc_0.551
TCTTCAGCA
0
40_e_k9me3-h1_0.551
TGGCCGAAT
0
41_e_k9me3-npc_0.550
AAAGCGTTA
0
42_e_k9me3-h1_0.550
AGTGGGGAG
3 MZF1_01_M00083_T,  YPR022C_01_M01647_T,  MZF1_Q5_M01733_T
43_e_k9me3-h1_0.550
AACCTCCAC
0
44_e_k9me3-npc_0.550
ACTAAAGGC
0
45_e_k9me3-h1_0.549
CAGGGTTTC
0
46_e_k9me3-h1_0.549
CATTCCCAAG
2 IK1_01_M00086_T,  LARP4_9_H
47_e_k9me3-h1_0.548
CCATAAAGG
0
48_e_k9me3-h1_0.547
ATCACTTGA
0
49_e_k9me3-h1_0.547
GTGTGAGCAC
0
50_h_k9me3-npc_0.547
CAATGACAATGC
0
51_e_k9me3-npc_0.546
CTAGGTGACT
0
52_h_k9me3-npc_0.545
ATCCGTGGAG
0
53_e_k9me3-h1_0.545
GGAGATCGA
0
54_e_k9me3-npc_0.545
ACGATCCA
0
55_e_k9me3-npc_0.545
AAAATACAC
0
56_e_k9me3-h1_0.544
CCATGTTA
0
57_e_k9me3-npc_0.544
GAAAGAAGA
0
58_e_k9me3-npc_0.543
AAATCCTAG
0
59_e_k9me3-h1_0.542
GATTTCTGC
0
60_e_k9me3-npc_0.542
CTCATTTGC
2 OCT_C_M00210_T,  nub_MA0453.1_J
61_e_k9me3-h1_0.541
AACCAGTCA
0
62_e_k9me3-h1_0.540
GAGGAATAAA
0
63_e_k9me3-npc_0.539
AGGTGACAT
0
64_e_k9me3-npc_0.538
AAGTATGGG
0
65_e_k9me3-npc_0.538
AGACGTGGG
0
66_e_k9me3-npc_0.536
CCAGTGGCC
0
67_e_k9me3-npc_0.536
TGAGCGCG
0
68_e_k9me3-h1_0.536
AAACTGCCT
0
69_e_k9me3-h1_0.536
AGATATTTC
0
70_h_k9me3-npc_0.536
TGCCTGAAGT
0
71_e_k9me3-npc_0.535
GAGACCTAA
0
72_e_k9me3-h1_0.535
AATCGCTTA
0
73_h_k9me3-h1_0.534
GACGGTCCCA
0
74_e_k9me3-h1_0.534
GATCCTGGAA
0
75_e_k9me3-h1_0.532
CATAGCTCA
0
76_e_k9me3-h1_0.530
AATAAATCT
0
77_e_k9me3-npc_0.530
ATTGATACC
0
78_e_k9me3-h1_0.529
GTGAATAA
0
79_e_k9me3-h1_0.529
TGTCCCTTG
0
80_e_k9me3-h1_0.528
TCTAACACA
0
81_e_k9me3-h1_0.528
ATCCTCAAA
0
82_e_k9me3-npc_0.527
CCATTGCACT
0
83_e_k9me3-h1_0.524
GTGGCTATA
0
84_h_k9me3-h1_0.524
AGATCGCC
1 NFMUE1_Q6_M00651_T
85_h_k9me3-h1_0.523
CTTGAAAGGGGA
2 MSN4_MA0342.1_J,  RGM1_MA0366.1_J
86_e_k9me3-h1_0.522
TCTCTGGGTC
0
87_e_k9me3-npc_0.518
GATGGGGTA
0
88_e_k9me3-h1_0.515
CATTACCAC
1 Ubx_MA0094.1_J
89_e_k9me3-npc_0.505
CAGCCTGGGC
0
90_h_k9me3-h1_0.505
ACTGCTCAATCA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 13

Matches to Query: 1_e_k9me3-h1_0.593

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Matches to Query: 2_e_k9me3-npc_0.587

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Summary 

Alignment 

Name RAV1_01_M00343_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.52833e-05
E-value 0.0446426
q-value 0.0892853
Overlap 11
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 3_e_k9me3-npc_0.583

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Matches to Query: 4_e_k9me3-npc_0.581

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Matches to Query: 5_e_k9me3-h1_0.574

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Matches to Query: 6_h_k9me3-npc_0.570

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Matches to Query: 7_h_k9me3-npc_0.569

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Matches to Query: 8_e_k9me3-h1_0.568

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Matches to Query: 9_e_k9me3-npc_0.567

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Matches to Query: 10_e_k9me3-h1_0.566

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Matches to Query: 11_e_k9me3-npc_0.565

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Matches to Query: 12_e_k9me3-npc_0.564

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Matches to Query: 13_e_k9me3-h1_0.564

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Matches to Query: 14_e_k9me3-h1_0.563

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Matches to Query: 15_h_k9me3-npc_0.563

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Matches to Query: 16_e_k9me3-npc_0.561

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Matches to Query: 17_e_k9me3-h1_0.561

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Matches to Query: 18_h_k9me3-npc_0.560

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Matches to Query: 19_e_k9me3-npc_0.560

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Matches to Query: 20_e_k9me3-npc_0.560

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Matches to Query: 21_e_k9me3-npc_0.559

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Matches to Query: 22_e_k9me3-h1_0.559

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Matches to Query: 23_e_k9me3-h1_0.558

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Matches to Query: 24_h_k9me3-npc_0.557

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Matches to Query: 25_e_k9me3-npc_0.557

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Matches to Query: 26_e_k9me3-h1_0.557

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Matches to Query: 27_e_k9me3-h1_0.557

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Matches to Query: 28_h_k9me3-npc_0.557

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Matches to Query: 29_e_k9me3-npc_0.556

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Matches to Query: 30_e_k9me3-h1_0.556

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Summary 

Alignment 

Name TERALPHA_Q6_M01724_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.43421e-06
E-value 0.0100313
q-value 0.0199702
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 31_e_k9me3-npc_0.555

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Matches to Query: 32_e_k9me3-npc_0.555

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Matches to Query: 33_e_k9me3-h1_0.555

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Matches to Query: 34_e_k9me3-npc_0.554

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Matches to Query: 35_e_k9me3-h1_0.553

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Matches to Query: 36_e_k9me3-h1_0.552

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Matches to Query: 37_e_k9me3-npc_0.552

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Matches to Query: 38_e_k9me3-h1_0.552

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Matches to Query: 39_e_k9me3-npc_0.551

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Matches to Query: 40_e_k9me3-h1_0.551

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Matches to Query: 41_e_k9me3-npc_0.550

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Matches to Query: 42_e_k9me3-h1_0.550

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Summary 

Alignment 

Name MZF1_01_M00083_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.44905e-06
E-value 0.0217587
q-value 0.0186431
Overlap 8
Offset 0
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name YPR022C_01_M01647_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.31279e-06
E-value 0.0242817
q-value 0.0186431
Overlap 6
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name MZF1_Q5_M01733_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.59974e-06
E-value 0.0280408
q-value 0.0186431
Overlap 7
Offset -2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 43_e_k9me3-h1_0.550

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Matches to Query: 44_e_k9me3-npc_0.550

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Matches to Query: 45_e_k9me3-h1_0.549

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Matches to Query: 46_e_k9me3-h1_0.549

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Summary 

Alignment 

Name IK1_01_M00086_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.49524e-06
E-value 0.00436759
q-value 0.00873517
Overlap 10
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name LARP4_9_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.04651e-05
E-value 0.0305685
q-value 0.0305685
Overlap 8
Offset -2
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 47_e_k9me3-h1_0.548

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Matches to Query: 48_e_k9me3-h1_0.547

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Matches to Query: 49_e_k9me3-h1_0.547

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Matches to Query: 50_h_k9me3-npc_0.547

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Matches to Query: 51_e_k9me3-npc_0.546

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Matches to Query: 52_h_k9me3-npc_0.545

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Matches to Query: 53_e_k9me3-h1_0.545

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Matches to Query: 54_e_k9me3-npc_0.545

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Matches to Query: 55_e_k9me3-npc_0.545

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Matches to Query: 56_e_k9me3-h1_0.544

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Matches to Query: 57_e_k9me3-npc_0.544

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Matches to Query: 58_e_k9me3-npc_0.543

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Matches to Query: 59_e_k9me3-h1_0.542

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Matches to Query: 60_e_k9me3-npc_0.542

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Summary 

Alignment 

Name OCT_C_M00210_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.16087e-06
E-value 0.0179959
q-value 0.0359374
Overlap 9
Offset 0
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name nub_MA0453.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.67145e-05
E-value 0.0488231
q-value 0.0487493
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 61_e_k9me3-h1_0.541

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Matches to Query: 62_e_k9me3-h1_0.540

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Matches to Query: 63_e_k9me3-npc_0.539

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Matches to Query: 64_e_k9me3-npc_0.538

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Matches to Query: 65_e_k9me3-npc_0.538

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Matches to Query: 66_e_k9me3-npc_0.536

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Matches to Query: 67_e_k9me3-npc_0.536

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Matches to Query: 68_e_k9me3-h1_0.536

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Matches to Query: 69_e_k9me3-h1_0.536

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Matches to Query: 70_h_k9me3-npc_0.536

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Matches to Query: 71_e_k9me3-npc_0.535

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Matches to Query: 72_e_k9me3-h1_0.535

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Matches to Query: 73_h_k9me3-h1_0.534

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Matches to Query: 74_e_k9me3-h1_0.534

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Matches to Query: 75_e_k9me3-h1_0.532

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Matches to Query: 76_e_k9me3-h1_0.530

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Matches to Query: 77_e_k9me3-npc_0.530

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Matches to Query: 78_e_k9me3-h1_0.529

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Matches to Query: 79_e_k9me3-h1_0.529

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Matches to Query: 80_e_k9me3-h1_0.528

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Matches to Query: 81_e_k9me3-h1_0.528

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Matches to Query: 82_e_k9me3-npc_0.527

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Matches to Query: 83_e_k9me3-h1_0.524

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Matches to Query: 84_h_k9me3-h1_0.524

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Summary 

Alignment 

Name NFMUE1_Q6_M00651_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.0318e-06
E-value 0.0263819
q-value 0.0527637
Overlap 8
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 85_h_k9me3-h1_0.523

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Summary 

Alignment 

Name MSN4_MA0342.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.66689e-05
E-value 0.0486898
q-value 0.048658
Overlap 5
Offset -6
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name RGM1_MA0366.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.66689e-05
E-value 0.0486898
q-value 0.048658
Overlap 5
Offset -6
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 86_e_k9me3-h1_0.522

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Matches to Query: 87_e_k9me3-npc_0.518

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Matches to Query: 88_e_k9me3-h1_0.515

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Summary 

Alignment 

Name Ubx_MA0094.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 0
E-value 0
q-value 0
Overlap 4
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 89_e_k9me3-npc_0.505

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Matches to Query: 90_h_k9me3-h1_0.505

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 209.867 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.