TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k4me3-mes_0.643
GGCTAACAG
0
2_e_k4me3-h1_0.628
AAATAAAAAT
1 CSTF2_5_H
3_h_k4me3-h1_0.623
GTAATATTCCCA
0
4_e_k4me3-mes_0.617
CATCTGGAC
1 RP58_01_M00532_T
5_e_k4me3-mes_0.614
GGTTCCAGA
0
6_e_k4me3-mes_0.613
AATTTCCAGT
4 MAGEA8_12_H,  HNRPH3_9_H,  HP1BP3_5_H,  H1FX_7_H
7_e_k4me3-mes_0.611
AAGTTTCCC
0
8_e_k4me3-mes_0.603
CTAACAGAA
0
9_e_k4me3-h1_0.602
GTGAAAAAC
0
10_e_k4me3-h1_0.601
ACTCAAACC
0
11_h_k4me3-h1_0.598
TTACCGCGCA
0
12_e_k4me3-mes_0.598
AGGGACTTCC
2 NFKB_C_M00208_T,  P50P50_Q3_M01223_T
13_e_k4me3-mes_0.596
AACTTTTACT
0
14_e_k4me3-h1_0.595
GACAAAGTGG
0
15_e_k4me3-h1_0.592
TCTTTCTCTCA
0
16_e_k4me3-h1_0.592
GTATCTCAC
0
17_e_k4me3-mes_0.591
CTGTTGAAGA
0
18_e_k4me3-mes_0.590
GGTTCTTAA
0
19_e_k4me3-mes_0.587
AACTTCAGT
0
20_e_k4me3-mes_0.587
CAGATTCTAC
0
21_h_k4me3-h1_0.587
ATTTCTCCGC
1 YPR196W_MA0437.1_J
22_e_k4me3-mes_0.585
AACTAGAG
0
23_e_k4me3-mes_0.585
CACCAAAAG
0
24_e_k4me3-mes_0.583
GAGACACCA
0
25_e_k4me3-mes_0.583
GGAAAAAAA
1 NFAT1_Q6_M01281_T
26_e_k4me3-mes_0.582
ACCTGGAGG
0
27_e_k4me3-mes_0.581
AGAACACAG
0
28_e_k4me3-h1_0.581
AAAGTGAAA
9 BLIMP1_01_M01775_T,  IRF_Q6_01_M00972_T,  IRF2_01_M00063_T,  IRF1_01_M00062_T,  IRF1_MA0050.1_J,  ISRE_01_M00258_T,  IRF2_MA0051.1_J,  ICSBP_Q6_M00699_T,  IRF_Q6_M00772_T
29_e_k4me3-h1_0.581
GTGTATTAA
0
30_e_k4me3-h1_0.580
CTAAATATC
0
31_h_k4me3-mes_0.579
CGGGAAAG
0
32_e_k4me3-mes_0.579
AGCACCCCA
0
33_e_k4me3-mes_0.579
TGAACCTTC
0
34_e_k4me3-mes_0.579
CTCATTTTAA
0
35_h_k4me3-mes_0.577
CTCTGAAACTTT
0
36_e_k4me3-mes_0.577
ACTTGAGTGT
1 TITF1_Q3_M00432_T
37_e_k4me3-h1_0.577
AGATTCCCA
0
38_e_k4me3-mes_0.575
CAGTGCCAAG
0
39_e_k4me3-mes_0.575
TGAGAGACACA
0
40_e_k4me3-h1_0.575
ATGTTGATA
0
41_e_k4me3-mes_0.574
GCAGCTAGA
0
42_h_k4me3-h1_0.574
AAAGGCTTTT
0
43_e_k4me3-h1_0.573
CCAGTGAGC
0
44_e_k4me3-h1_0.572
CGACAGTAG
0
45_e_k4me3-mes_0.572
AAAAACTGC
0
46_e_k4me3-h1_0.570
GATGAGCA
0
47_e_k4me3-h1_0.568
GCTGGGGCC
0
48_e_k4me3-mes_0.568
CAATCCGG
0
49_e_k4me3-h1_0.565
ATATTAATG
0
50_e_k4me3-mes_0.564
CACCTTGGG
0
51_e_k4me3-mes_0.564
AAACACTTG
0
52_e_k4me3-mes_0.563
AGAGATGCC
0
53_e_k4me3-mes_0.563
ACCTCCAAAC
0
54_e_k4me3-mes_0.560
CTCCCCTCCA
0
55_h_k4me3-mes_0.560
TTTCGTCC
0
56_e_k4me3-h1_0.560
ACCGCGCAG
1 Zfp161_secondary_SCI09_U
57_h_k4me3-h1_0.560
GGGCCCGCGTCG
0
58_e_k4me3-h1_0.558
AGTTCTTAAA
0
59_e_k4me3-mes_0.558
GGTCACCA
1 GTF3C5_2_H
60_e_k4me3-mes_0.558
TTGCCAAAA
1 YEATS4_16_H
61_e_k4me3-mes_0.558
GTGTTTTTAA
0
62_e_k4me3-h1_0.556
AATGTCAGGC
0
63_e_k4me3-h1_0.555
AATGCAAATA
1 OCT1_Q5_01_M00930_T
64_e_k4me3-mes_0.555
GAATAGAAA
0
65_h_k4me3-mes_0.555
TTAACAGCCAAA
0
66_e_k4me3-mes_0.555
TAAAGTGGA
0
67_e_k4me3-mes_0.555
AGAAACATC
0
68_e_k4me3-mes_0.554
GCATGGAGA
0
69_e_k4me3-h1_0.553
AGGACCCA
0
70_e_k4me3-mes_0.552
GTGATTAAA
0
71_e_k4me3-h1_0.551
ACATTATTC
0
72_e_k4me3-h1_0.551
AAGCCTGCGC
0
73_e_k4me3-h1_0.548
ATCTAATAC
0
74_e_k4me3-h1_0.545
TCCAGGAAA
3 STAT5B_01_M00459_T,  Stat3_MA0144.1_J,  TR4_01_M01776_T
75_e_k4me3-mes_0.544
AACCCTTTAG
0
76_e_k4me3-mes_0.544
ACTCATCA
0
77_e_k4me3-h1_0.543
TCTCCTCCA
0
78_e_k4me3-h1_0.541
CAGCAGTGA
0
79_e_k4me3-h1_0.540
CAATGGCCA
0
80_e_k4me3-h1_0.539
ACTTCACCTC
0
81_e_k4me3-mes_0.538
AAAGGGGGT
0
82_e_k4me3-mes_0.536
AAAACAAAGG
2 TCF3_01_M01594_T,  SMAD1_01_M01590_T
83_h_k4me3-h1_0.534
TGACACGTAA
0
84_e_k4me3-h1_0.532
ACATGCATC
0
85_e_k4me3-h1_0.532
AACCTCAGA
0
86_e_k4me3-h1_0.527
AGGACTTTCC
0
87_e_k4me3-h1_0.525
GACACAAT
0
88_e_k4me3-h1_0.525
CTGCAGGTC
0
89_e_k4me3-h1_0.520
CCTTATGTA
0
90_h_k4me3-mes_0.515
GTGTGTGAGT
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 29

Matches to Query: 1_e_k4me3-mes_0.643

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Matches to Query: 2_e_k4me3-h1_0.628

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Summary 

Alignment 

Name CSTF2_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.34162e-06
E-value 0.00391887
q-value 0.00776648
Overlap 7
Offset 0
Orientation Normal
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Matches to Query: 3_h_k4me3-h1_0.623

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Matches to Query: 4_e_k4me3-mes_0.617

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Summary 

Alignment 

Name RP58_01_M00532_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.40799e-05
E-value 0.0411273
q-value 0.0710723
Overlap 8
Offset 4
Orientation Normal
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Matches to Query: 5_e_k4me3-mes_0.614

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Matches to Query: 6_e_k4me3-mes_0.613

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Summary 

Alignment 

Name MAGEA8_12_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.91554e-06
E-value 0.0085163
q-value 0.0121333
Overlap 7
Offset -2
Orientation Reverse Complement
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Summary 

Alignment 

Name HNRPH3_9_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.38363e-06
E-value 0.0157256
q-value 0.0121333
Overlap 6
Offset -3
Orientation Reverse Complement
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Summary 

Alignment 

Name HP1BP3_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.2911e-06
E-value 0.0183763
q-value 0.0121333
Overlap 7
Offset -2
Orientation Reverse Complement
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Summary 

Alignment 

Name H1FX_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.31461e-05
E-value 0.0383997
q-value 0.0190156
Overlap 7
Offset -2
Orientation Reverse Complement
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Matches to Query: 7_e_k4me3-mes_0.611

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Matches to Query: 8_e_k4me3-mes_0.603

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Matches to Query: 9_e_k4me3-h1_0.602

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Matches to Query: 10_e_k4me3-h1_0.601

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Matches to Query: 11_h_k4me3-h1_0.598

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Matches to Query: 12_e_k4me3-mes_0.598

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Summary 

Alignment 

Name NFKB_C_M00208_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.1557e-05
E-value 0.0337581
q-value 0.0357028
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name P50P50_Q3_M01223_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.22228e-05
E-value 0.0357028
q-value 0.0357028
Overlap 10
Offset 1
Orientation Normal
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Matches to Query: 13_e_k4me3-mes_0.596

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Matches to Query: 14_e_k4me3-h1_0.595

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Matches to Query: 15_e_k4me3-h1_0.592

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Matches to Query: 16_e_k4me3-h1_0.592

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Matches to Query: 17_e_k4me3-mes_0.591

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Matches to Query: 18_e_k4me3-mes_0.590

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Matches to Query: 19_e_k4me3-mes_0.587

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Matches to Query: 20_e_k4me3-mes_0.587

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Matches to Query: 21_h_k4me3-h1_0.587

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Summary 

Alignment 

Name YPR196W_MA0437.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.28718e-06
E-value 0.00960186
q-value 0.019178
Overlap 9
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 22_e_k4me3-mes_0.585

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Matches to Query: 23_e_k4me3-mes_0.585

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Matches to Query: 24_e_k4me3-mes_0.583

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Matches to Query: 25_e_k4me3-mes_0.583

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Summary 

Alignment 

Name NFAT1_Q6_M01281_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.62185e-05
E-value 0.0473744
q-value 0.0945077
Overlap 6
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 26_e_k4me3-mes_0.582

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Matches to Query: 27_e_k4me3-mes_0.581

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Matches to Query: 28_e_k4me3-h1_0.581

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Summary 

Alignment 

Name BLIMP1_01_M01775_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.17532e-07
E-value 0.000343311
q-value 0.000686411
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name IRF_Q6_01_M00972_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.88061e-07
E-value 0.00288613
q-value 0.00288524
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name IRF2_01_M00063_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.13067e-06
E-value 0.0062237
q-value 0.0029035
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name IRF1_01_M00062_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.40947e-06
E-value 0.00703806
q-value 0.0029035
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name IRF1_MA0050.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.73259e-06
E-value 0.00798189
q-value 0.0029035
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name ISRE_01_M00258_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.98294e-06
E-value 0.00871318
q-value 0.0029035
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name IRF2_MA0051.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.43035e-06
E-value 0.015862
q-value 0.00453062
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name ICSBP_Q6_M00699_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.17929e-05
E-value 0.0344471
q-value 0.00860912
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name IRF_Q6_M00772_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.58477e-05
E-value 0.0462912
q-value 0.0102838
Overlap 9
Offset 1
Orientation Reverse Complement
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Matches to Query: 29_e_k4me3-h1_0.581

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Matches to Query: 30_e_k4me3-h1_0.580

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Matches to Query: 31_h_k4me3-mes_0.579

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Matches to Query: 32_e_k4me3-mes_0.579

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Matches to Query: 33_e_k4me3-mes_0.579

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Matches to Query: 34_e_k4me3-mes_0.579

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Matches to Query: 35_h_k4me3-mes_0.577

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Matches to Query: 36_e_k4me3-mes_0.577

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Summary 

Alignment 

Name TITF1_Q3_M00432_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.69052e-05
E-value 0.0493802
q-value 0.0987605
Overlap 8
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 37_e_k4me3-h1_0.577

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Matches to Query: 38_e_k4me3-mes_0.575

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Matches to Query: 39_e_k4me3-mes_0.575

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Matches to Query: 40_e_k4me3-h1_0.575

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Matches to Query: 41_e_k4me3-mes_0.574

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Matches to Query: 42_h_k4me3-h1_0.574

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Matches to Query: 43_e_k4me3-h1_0.573

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Matches to Query: 44_e_k4me3-h1_0.572

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Matches to Query: 45_e_k4me3-mes_0.572

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Matches to Query: 46_e_k4me3-h1_0.570

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Matches to Query: 47_e_k4me3-h1_0.568

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Matches to Query: 48_e_k4me3-mes_0.568

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Matches to Query: 49_e_k4me3-h1_0.565

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Matches to Query: 50_e_k4me3-mes_0.564

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Matches to Query: 51_e_k4me3-mes_0.564

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Matches to Query: 52_e_k4me3-mes_0.563

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Matches to Query: 53_e_k4me3-mes_0.563

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Matches to Query: 54_e_k4me3-mes_0.560

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Matches to Query: 55_h_k4me3-mes_0.560

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Matches to Query: 56_e_k4me3-h1_0.560

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Summary 

Alignment 

Name Zfp161_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.32462e-06
E-value 0.0243162
q-value 0.0486324
Overlap 9
Offset 0
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 57_h_k4me3-h1_0.560

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Matches to Query: 58_e_k4me3-h1_0.558

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Matches to Query: 59_e_k4me3-mes_0.558

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Summary 

Alignment 

Name GTF3C5_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.12007e-05
E-value 0.0327173
q-value 0.0653018
Overlap 6
Offset 0
Orientation Reverse Complement
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Matches to Query: 60_e_k4me3-mes_0.558

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Summary 

Alignment 

Name YEATS4_16_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.20868e-05
E-value 0.0353057
q-value 0.0706113
Overlap 6
Offset -2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 61_e_k4me3-mes_0.558

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Matches to Query: 62_e_k4me3-h1_0.556

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Matches to Query: 63_e_k4me3-h1_0.555

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Summary 

Alignment 

Name OCT1_Q5_01_M00930_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.16614e-05
E-value 0.0340631
q-value 0.0430997
Overlap 10
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 64_e_k4me3-mes_0.555

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Matches to Query: 65_h_k4me3-mes_0.555

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Matches to Query: 66_e_k4me3-mes_0.555

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Matches to Query: 67_e_k4me3-mes_0.555

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Matches to Query: 68_e_k4me3-mes_0.554

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Matches to Query: 69_e_k4me3-h1_0.553

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Matches to Query: 70_e_k4me3-mes_0.552

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Matches to Query: 71_e_k4me3-h1_0.551

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Matches to Query: 72_e_k4me3-h1_0.551

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Matches to Query: 73_e_k4me3-h1_0.548

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Matches to Query: 74_e_k4me3-h1_0.545

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Summary 

Alignment 

Name STAT5B_01_M00459_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.65696e-06
E-value 0.022366
q-value 0.0270195
Overlap 9
Offset 4
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name Stat3_MA0144.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.01894e-05
E-value 0.0297633
q-value 0.0270195
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TR4_01_M01776_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.42325e-05
E-value 0.0415731
q-value 0.0270195
Overlap 7
Offset -1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 75_e_k4me3-mes_0.544

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Matches to Query: 76_e_k4me3-mes_0.544

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Matches to Query: 77_e_k4me3-h1_0.543

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Matches to Query: 78_e_k4me3-h1_0.541

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Matches to Query: 79_e_k4me3-h1_0.540

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Matches to Query: 80_e_k4me3-h1_0.539

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Matches to Query: 81_e_k4me3-mes_0.538

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Matches to Query: 82_e_k4me3-mes_0.536

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Summary 

Alignment 

Name TCF3_01_M01594_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.12836e-06
E-value 0.020822
q-value 0.0264404
Overlap 10
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name SMAD1_01_M01590_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.09847e-06
E-value 0.0265766
q-value 0.0264404
Overlap 10
Offset 1
Orientation Normal
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Matches to Query: 83_h_k4me3-h1_0.534

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Matches to Query: 84_e_k4me3-h1_0.532

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Matches to Query: 85_e_k4me3-h1_0.532

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Matches to Query: 86_e_k4me3-h1_0.527

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Matches to Query: 87_e_k4me3-h1_0.525

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Matches to Query: 88_e_k4me3-h1_0.525

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Matches to Query: 89_e_k4me3-h1_0.520

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Matches to Query: 90_h_k4me3-mes_0.515

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 205.605 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.