TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_re_46_0.407
CGCCACTGC
0
2_re_40_0.411
AGGCGTGAG
0
3_re_30_0.414
CAAGCGATTC
0
4_re_24_0.414
ACCCCGTCTC
0
5_re_104_0.416
TAGCTGGGA
1 LUN1_01_M00480_T
6_re_10_0.416
CGTCTCTAC
0
7_re_73_0.417
CAGCTACTCT
0
8_re_19_0.418
CCCGAGTAG
0
9_re_115_0.420
CACTCCAGC
0
10_re_23_0.421
GAGAATCGC
0
11_re_9_0.422
AGATCGCGC
0
12_re_39_0.425
CACCATGTTG
0
13_re_6_0.426
AAATTAGCC
0
14_re_38_0.428
CCGGGTTCAA
0
15_re_25_0.431
AGATCGAGA
0
16_e_205_0.566
CCCAGTGAG
0
17_re_101_0.436
GCCTGGCTA
0
18_e_88_0.436
ATACCGAC
0
19_re_63_0.436
GGGTTTCAC
0
20_re_123_0.440
AACCTCTGC
0
21_re_233_0.440
ACGACG
0
22_re_69_0.441
CTGTCACCCA
0
23_e_110_0.554
GCTTTTCCA
5 MYLK_6_H,  MAGED4_4_H,  NFATC2_MA0152.1_J,  NFATC3_14_H,  NFATC4_10_H
24_e_212_0.553
CAGATGGAA
0
25_re_226_0.448
GAGACGCT
0
26_re_137_0.449
AAAAAAAAA
1 Srf_secondary_SCI09_U
27_h_2_0.551
AATGCACACATC
0
28_e_145_0.550
CCACTGTCCT
0
29_e_37_0.548
GACGGGTGA
0
30_e_106_0.547
CAGCGTGAG
0
31_re_151_0.454
AAGATCGTG
0
32_e_91_0.546
TGAGATGAA
0
33_e_224_0.456
ACGACGTC
0
34_e_196_0.543
GGAATTCCC
5 NF-kappaB_MA0061.1_J,  NFKAPPAB_01_M00054_T,  P50P50_Q3_M01223_T,  NFKB_Q6_01_M00774_T,  P50RELAP65_Q5_01_M01224_T
35_re_163_0.458
ACCTCCACC
1 HMO1_CA_01_M01792_T
36_re_199_0.461
CCGTGCGT
0
37_h_3_0.539
CCTATTCGGCCA
0
38_e_49_0.538
GAATCACAGA
0
39_e_32_0.538
GCATTCTCAGA
0
40_re_201_0.467
CACTGCAAG
0
41_e_96_0.531
ATATCTTCA
0
42_e_53_0.527
ATAGAGCAGG
0
43_e_29_0.527
CCATAGGCC
0
44_e_260_0.526
CCATGTAAT
0
45_h_22_0.522
AAGAAAGGTT
0
46_e_119_0.520
CCAAATGTC
0
47_e_237_0.519
CATTCATAG
0
48_e_22_0.519
AAACTGCTCT
0
49_e_60_0.483
CAACGAAC
0
50_e_78_0.503
ACAGACGGC
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 13

Matches to Query: 1_re_46_0.407

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Matches to Query: 2_re_40_0.411

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Matches to Query: 3_re_30_0.414

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Matches to Query: 4_re_24_0.414

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Matches to Query: 5_re_104_0.416

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Summary 

Alignment 

Name LUN1_01_M00480_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.24073e-07
E-value 0.000946618
q-value 0.00189324
Overlap 9
Offset 8
Orientation Reverse Complement
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Matches to Query: 6_re_10_0.416

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Matches to Query: 7_re_73_0.417

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Matches to Query: 8_re_19_0.418

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Matches to Query: 9_re_115_0.420

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Matches to Query: 10_re_23_0.421

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Matches to Query: 11_re_9_0.422

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Matches to Query: 12_re_39_0.425

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Matches to Query: 13_re_6_0.426

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Matches to Query: 14_re_38_0.428

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Matches to Query: 15_re_25_0.431

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Matches to Query: 16_e_205_0.566

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Matches to Query: 17_re_101_0.436

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Matches to Query: 18_e_88_0.436

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Matches to Query: 19_re_63_0.436

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Matches to Query: 20_re_123_0.440

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Matches to Query: 21_re_233_0.440

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Matches to Query: 22_re_69_0.441

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Matches to Query: 23_e_110_0.554

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Summary 

Alignment 

Name MYLK_6_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.45674e-06
E-value 0.0188601
q-value 0.0185311
Overlap 6
Offset -3
Orientation Reverse Complement
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Summary 

Alignment 

Name MAGED4_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.62161e-06
E-value 0.0251837
q-value 0.0185311
Overlap 6
Offset -3
Orientation Reverse Complement
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Summary 

Alignment 

Name NFATC2_MA0152.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.05303e-05
E-value 0.0307591
q-value 0.0185311
Overlap 7
Offset -2
Orientation Normal
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Summary 

Alignment 

Name NFATC3_14_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.59834e-05
E-value 0.0466875
q-value 0.0185311
Overlap 6
Offset -3
Orientation Reverse Complement
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Summary 

Alignment 

Name NFATC4_10_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.59834e-05
E-value 0.0466875
q-value 0.0185311
Overlap 6
Offset -3
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 24_e_212_0.553

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Matches to Query: 25_re_226_0.448

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Matches to Query: 26_re_137_0.449

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Summary 

Alignment 

Name Srf_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.87081e-06
E-value 0.0200696
q-value 0.0401338
Overlap 9
Offset 4
Orientation Normal
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Matches to Query: 27_h_2_0.551

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Matches to Query: 28_e_145_0.550

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Matches to Query: 29_e_37_0.548

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Matches to Query: 30_e_106_0.547

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Matches to Query: 31_re_151_0.454

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Matches to Query: 32_e_91_0.546

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Matches to Query: 33_e_224_0.456

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Matches to Query: 34_e_196_0.543

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Summary 

Alignment 

Name NF-kappaB_MA0061.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.24102e-06
E-value 0.00362501
q-value 0.0036083
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name NFKAPPAB_01_M00054_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.24102e-06
E-value 0.00362501
q-value 0.0036083
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name P50P50_Q3_M01223_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.91224e-06
E-value 0.00558565
q-value 0.00370661
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name NFKB_Q6_01_M00774_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.17308e-05
E-value 0.0342657
q-value 0.0113693
Overlap 9
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name P50RELAP65_Q5_01_M01224_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.64335e-05
E-value 0.0480023
q-value 0.0136517
Overlap 9
Offset 0
Orientation Normal
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Matches to Query: 35_re_163_0.458

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Summary 

Alignment 

Name HMO1_CA_01_M01792_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.51821e-05
E-value 0.0443469
q-value 0.0886938
Overlap 9
Offset 2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 36_re_199_0.461

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Matches to Query: 37_h_3_0.539

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Matches to Query: 38_e_49_0.538

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Matches to Query: 39_e_32_0.538

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Matches to Query: 40_re_201_0.467

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Matches to Query: 41_e_96_0.531

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Matches to Query: 42_e_53_0.527

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Matches to Query: 43_e_29_0.527

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Matches to Query: 44_e_260_0.526

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Matches to Query: 45_h_22_0.522

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Matches to Query: 46_e_119_0.520

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Matches to Query: 47_e_237_0.519

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Matches to Query: 48_e_22_0.519

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Matches to Query: 49_e_60_0.483

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Matches to Query: 50_e_78_0.503

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 114.320 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.