TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_re_28_0.356
GGGATTACA
1 PITX2_Q2_M00482_T
2_re_23_0.361
GTCTCGAAC
1 RPC155_01_M01798_T
3_re_41_0.366
AGGCTGAGG
0
4_re_29_0.366
CTGGGCAACAGAG
0
5_re_37_0.366
CGATCTCGGC
0
6_re_3_0.367
ATCGCTTGAAC
0
7_re_94_0.374
TAGCTGGGA
1 LUN1_01_M00480_T
8_re_86_0.378
GCTCATGCC
0
9_re_40_0.379
TGGTGGCTCA
0
10_re_0_0.380
ACGCCTGTA
0
11_re_27_0.380
AACCCCGTC
0
12_re_13_0.382
CCGTCTCTA
0
13_re_67_0.385
GGGTTTCAC
0
14_re_19_0.390
AGGAGAATCG
0
15_re_176_0.393
GGAAGCCGAG
0
16_re_8_0.400
AAATTAGCC
0
17_re_100_0.400
GATCACACC
0
18_re_140_0.400
ATGGTCTCG
0
19_re_7_0.401
CCCGAGTAGC
0
20_re_42_0.404
AACATGGTGA
0
21_re_112_0.405
CACTTTGGG
0
22_re_181_0.407
CCATTGCAC
0
23_re_39_0.407
GCCCGCCACGAG
0
24_e_419_0.414
CTACGATT
0
25_re_129_0.415
AAGTGCTGG
0
26_e_118_0.576
ATGCAAATGA
10 OCT_C_M00210_T,  OCT_Q6_M00795_T,  IL24_5_H,  nub_MA0453.1_J,  Pou2f3_3986.2_Cell08_U,  OCT1_Q5_01_M00930_T,  POU2F3_01_M01476_T,  OCT2_01_M01368_T,  Pou2f2_3748.1_Cell08_U,  OCT1_B_M00342_T
27_e_262_0.429
TAACGGGTA
0
28_h_5_0.568
GTAAGCAC
0
29_re_221_0.437
TGTGACGTCATC
10 Atf1_primary_SCI09_U,  STF1_02_M01187_T,  TGA2_01_M01586_T,  ATF3_Q6_M00513_T,  Jundm2_primary_SCI09_U,  STF1_01_M01186_T,  CREB_Q4_M00178_T,  VJUN_01_M00036_T,  ATF_B_M00338_T,  CREB1_MA0018.2_J
30_h_11_0.560
CCTCTGAGCA
0
31_e_79_0.445
ATACCGAAA
0
32_h_13_0.550
GCTGTCAG
2 achi_MA0207.1_J,  TGIF_01_M00418_T
33_re_247_0.454
CCACGATCA
0
34_re_174_0.544
CCATTCATT
2 Hbp1_primary_SCI09_U,  THAP5_4_H
35_h_24_0.544
AAGTCACT
0
36_h_14_0.543
ACTTGTCC
0
37_e_268_0.542
GTGTATGCAT
0
38_e_12_0.537
CGTGTGTAC
0
39_e_297_0.535
ACAGAACAC
0
40_e_434_0.534
CCTTAATAC
0
41_h_18_0.533
ACAAACGC
0
42_e_175_0.470
GTCTTCGGA
0
43_h_25_0.530
ACCAACTG
2 Mybl1_secondary_SCI09_U,  Myb_secondary_SCI09_U
44_e_314_0.523
AATGTGGCTATC
0
45_re_223_0.479
AGGAGGAAG
0
46_e_251_0.521
CCACTAGC
0
47_e_450_0.481
TCCAGGTA
0
48_e_112_0.485
AACTTTACG
0
49_e_568_0.493
CGTCTTTGTA
0
50_e_519_0.499
TATCGCTAA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 29

Matches to Query: 1_re_28_0.356

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Summary 

Alignment 

Name PITX2_Q2_M00482_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.53844e-06
E-value 0.0190988
q-value 0.0381976
Overlap 9
Offset 2
Orientation Reverse Complement
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Matches to Query: 2_re_23_0.361

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.61585e-06
E-value 0.0222459
q-value 0.0444918
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 3_re_41_0.366

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Matches to Query: 4_re_29_0.366

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Matches to Query: 5_re_37_0.366

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Matches to Query: 6_re_3_0.367

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Matches to Query: 7_re_94_0.374

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Summary 

Alignment 

Name LUN1_01_M00480_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.51175e-07
E-value 0.00131788
q-value 0.00263576
Overlap 9
Offset 8
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 8_re_86_0.378

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Matches to Query: 9_re_40_0.379

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Matches to Query: 10_re_0_0.380

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Matches to Query: 11_re_27_0.380

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Matches to Query: 12_re_13_0.382

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Matches to Query: 13_re_67_0.385

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Matches to Query: 14_re_19_0.390

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Matches to Query: 15_re_176_0.393

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Matches to Query: 16_re_8_0.400

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Matches to Query: 17_re_100_0.400

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Matches to Query: 18_re_140_0.400

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Matches to Query: 19_re_7_0.401

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Matches to Query: 20_re_42_0.404

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Matches to Query: 21_re_112_0.405

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Matches to Query: 22_re_181_0.407

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Matches to Query: 23_re_39_0.407

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Matches to Query: 24_e_419_0.414

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Matches to Query: 25_re_129_0.415

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Matches to Query: 26_e_118_0.576

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Summary 

Alignment 

Name OCT_C_M00210_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.1627e-07
E-value 0.00209222
q-value 0.00321474
Overlap 10
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name OCT_Q6_M00795_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.65299e-06
E-value 0.00482838
q-value 0.00321474
Overlap 10
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name IL24_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.99206e-06
E-value 0.0058188
q-value 0.00321474
Overlap 8
Offset -1
Orientation Normal
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Summary 

Alignment 

Name nub_MA0453.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.31783e-06
E-value 0.00677037
q-value 0.00321474
Overlap 10
Offset 1
Orientation Normal
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Summary 

Alignment 

Name Pou2f3_3986.2_Cell08_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.03031e-06
E-value 0.0117725
q-value 0.00321474
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name OCT1_Q5_01_M00930_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.46217e-06
E-value 0.013034
q-value 0.00321474
Overlap 10
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name POU2F3_01_M01476_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.48275e-06
E-value 0.0130941
q-value 0.00321474
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name OCT2_01_M01368_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.97718e-06
E-value 0.0145383
q-value 0.00321474
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Pou2f2_3748.1_Cell08_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.97718e-06
E-value 0.0145383
q-value 0.00321474
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name OCT1_B_M00342_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.10174e-05
E-value 0.0321817
q-value 0.00640446
Overlap 9
Offset 1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 27_e_262_0.429

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Matches to Query: 28_h_5_0.568

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Matches to Query: 29_re_221_0.437

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Summary 

Alignment 

Name Atf1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.34048e-07
E-value 0.00185205
q-value 0.00145072
Overlap 12
Offset 2
Orientation Normal
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Summary 

Alignment 

Name STF1_02_M01187_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.47072e-07
E-value 0.0024743
q-value 0.00145072
Overlap 12
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name TGA2_01_M01586_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.06631e-06
E-value 0.00311468
q-value 0.00145072
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ATF3_Q6_M00513_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.15024e-06
E-value 0.00335984
q-value 0.00145072
Overlap 12
Offset 1
Orientation Normal
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Summary 

Alignment 

Name Jundm2_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.39192e-06
E-value 0.00406579
q-value 0.00145072
Overlap 12
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name STF1_01_M01186_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.01601e-06
E-value 0.00588878
q-value 0.00145072
Overlap 12
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name CREB_Q4_M00178_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.40575e-06
E-value 0.0099482
q-value 0.00217846
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name VJUN_01_M00036_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.22042e-06
E-value 0.0181698
q-value 0.00358096
Overlap 12
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name ATF_B_M00338_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.58101e-06
E-value 0.0250651
q-value 0.00436604
Overlap 11
Offset -1
Orientation Normal
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Summary 

Alignment 

Name CREB1_MA0018.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.10099e-06
E-value 0.026584
q-value 0.00436604
Overlap 8
Offset -2
Orientation Reverse Complement
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Matches to Query: 30_h_11_0.560

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Matches to Query: 31_e_79_0.445

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Matches to Query: 32_h_13_0.550

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Summary 

Alignment 

Name achi_MA0207.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.58025e-06
E-value 0.0221419
q-value 0.0233646
Overlap 6
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name TGIF_01_M00418_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.03031e-06
E-value 0.0234565
q-value 0.0233646
Overlap 8
Offset 1
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 33_re_247_0.454

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Matches to Query: 34_re_174_0.544

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Summary 

Alignment 

Name Hbp1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.71038e-06
E-value 0.00499603
q-value 0.00999071
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name THAP5_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.27326e-05
E-value 0.037192
q-value 0.037187
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 35_h_24_0.544

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Matches to Query: 36_h_14_0.543

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Matches to Query: 37_e_268_0.542

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Matches to Query: 38_e_12_0.537

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Matches to Query: 39_e_297_0.535

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Matches to Query: 40_e_434_0.534

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Matches to Query: 41_h_18_0.533

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Matches to Query: 42_e_175_0.470

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Matches to Query: 43_h_25_0.530

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Summary 

Alignment 

Name Mybl1_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.39189e-06
E-value 0.00990772
q-value 0.0183977
Overlap 8
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Myb_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.29841e-06
E-value 0.0183977
q-value 0.0183977
Overlap 8
Offset 2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 44_e_314_0.523

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Matches to Query: 45_re_223_0.479

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Matches to Query: 46_e_251_0.521

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Matches to Query: 47_e_450_0.481

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Matches to Query: 48_e_112_0.485

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Matches to Query: 49_e_568_0.493

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Matches to Query: 50_e_519_0.499

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 118.724 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.