TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k4me3_2_0.782
CCGCCGCCG
3 ERF2_01_M01057_T,  ADF1_Q6_M00171_T,  ETF_Q6_M00695_T
2_h_k4me3_3_0.750
CGCGTTTT
0
3_h_k4me3_1_0.736
CCGGAAGCAA
24 ELK1_02_M00025_T,  ELF2_10_H,  Ehf_EMBO10_U,  ETV4_13_H,  Ehf_primary_SCI09_U,  Ets1_EMBO10_U,  Eip74EF_MA0026.1_J,  CETS1P54_03_M01078_T,  Elk3_EMBO10_U,  Elf3_EMBO10_U
4_h_k4me3_12_0.710
CTGCGCATGCGC
3 ZFP206_01_M01742_T,  NRF1_Q6_M00652_T,  HIST1H2BN_4_H
5_e_k4me3_17_0.689
CGCGGAGCCT
0
6_h_k4me3_14_0.680
GTTTCGAACCGG
0
7_h_k4me3_22_0.655
TCCGGTCTCCGA
0
8_e_k27me3_191_0.651
CCGCGTAA
0
9_e_k4me3_83_0.641
AGAGGCGCC
0
10_e_k9me3_135_0.376
CCCACTGTC
1 AP2REP_01_M00468_T
11_e_k36me3_193_0.378
GGCCAGGCA
0
12_e_k27me3_327_0.619
ATAATACCG
0
13_e_k9me3_208_0.386
CCAGCTGAG
1 AP4_Q6_M00176_T
14_e_k9me3_26_0.386
CACATCACAT
0
15_e_k36me3_169_0.409
ACCAACATG
0
16_e_k27ac_106_0.410
GACTCAGCC
3 MAF_Q6_01_M00983_T,  NFE2_01_M00037_T,  NRF2_Q4_M00821_T
17_e_k4me1_75_0.415
AGCACACTCA
0
18_e_k4me1_503_0.417
CATTTGGCA
0
19_e_k36me3_152_0.430
CAAGACCAG
0
20_h_k36me3_19_0.538
CGGAAGGCCTTC
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 35

Matches to Query: 1_e_k4me3_2_0.782

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Summary 

Alignment 

Name ERF2_01_M01057_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.78879e-06
E-value 0.00814607
q-value 0.016144
Overlap 7
Offset -1
Orientation Normal
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Summary 

Alignment 

Name ADF1_Q6_M00171_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.14105e-05
E-value 0.0333301
q-value 0.0290368
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ETF_Q6_M00695_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50478e-05
E-value 0.0439547
q-value 0.0290368
Overlap 7
Offset 0
Orientation Reverse Complement
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Matches to Query: 2_h_k4me3_3_0.750

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Matches to Query: 3_h_k4me3_1_0.736

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Summary 

Alignment 

Name ELK1_02_M00025_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.5833e-08
E-value 0.000192298
q-value 0.000374583
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name ELF2_10_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.31333e-07
E-value 0.00125992
q-value 0.00101445
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Ehf_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.3487e-07
E-value 0.00156236
q-value 0.00101445
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ETV4_13_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.28246e-07
E-value 0.00241931
q-value 0.00111925
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Ehf_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.06751e-06
E-value 0.00311819
q-value 0.00111925
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Ets1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.18025e-06
E-value 0.0034475
q-value 0.00111925
Overlap 10
Offset 6
Orientation Normal
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Summary 

Alignment 

Name Eip74EF_MA0026.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.95436e-06
E-value 0.00570868
q-value 0.00150601
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name CETS1P54_03_M01078_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.11745e-06
E-value 0.00618508
q-value 0.00150601
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Elk3_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.86261e-06
E-value 0.00836169
q-value 0.00180978
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Elf3_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.37811e-06
E-value 0.00986746
q-value 0.00192211
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Elk4_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.08292e-06
E-value 0.0119262
q-value 0.00207217
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name E74A_01_M00016_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.65627e-06
E-value 0.013601
q-value 0.00207217
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name GABPA_MA0062.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.73438e-06
E-value 0.0138291
q-value 0.00207217
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Gm4881_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.64661e-06
E-value 0.0252567
q-value 0.00329546
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ETS_class_MF0001.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.18531e-06
E-value 0.0268303
q-value 0.00329546
Overlap 7
Offset 1
Orientation Normal
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Summary 

Alignment 

Name Etv1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.84601e-06
E-value 0.0287602
q-value 0.00329546
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Etv6_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.84601e-06
E-value 0.0287602
q-value 0.00329546
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Elk1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.13438e-05
E-value 0.0331352
q-value 0.00358583
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Sip4_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.34442e-05
E-value 0.0392706
q-value 0.00366974
Overlap 10
Offset 8
Orientation Reverse Complement
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Summary 

Alignment 

Name SAP1A_01_M01167_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.37731e-05
E-value 0.0402312
q-value 0.00366974
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Erg_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50386e-05
E-value 0.0439279
q-value 0.00366974
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Fli1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50386e-05
E-value 0.0439279
q-value 0.00366974
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ERG_01_M01752_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.53187e-05
E-value 0.0447459
q-value 0.00366974
Overlap 8
Offset 1
Orientation Normal
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Summary 

Alignment 

Name SIP4_01_M01517_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.5479e-05
E-value 0.0452141
q-value 0.00366974
Overlap 10
Offset 8
Orientation Reverse Complement
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Matches to Query: 4_h_k4me3_12_0.710

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Summary 

Alignment 

Name ZFP206_01_M01742_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.41241e-10
E-value 9.96765e-07
q-value 1.99353e-06
Overlap 11
Offset -1
Orientation Normal
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Summary 

Alignment 

Name NRF1_Q6_M00652_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.78387e-07
E-value 0.000813168
q-value 0.000542112
Overlap 10
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name HIST1H2BN_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.39513e-07
E-value 0.00128382
q-value 0.000641909
Overlap 9
Offset -3
Orientation Reverse Complement
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Matches to Query: 5_e_k4me3_17_0.689

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Matches to Query: 6_h_k4me3_14_0.680

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Matches to Query: 7_h_k4me3_22_0.655

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Matches to Query: 8_e_k27me3_191_0.651

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Matches to Query: 9_e_k4me3_83_0.641

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Matches to Query: 10_e_k9me3_135_0.376

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Summary 

Alignment 

Name AP2REP_01_M00468_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.23029e-06
E-value 0.0152777
q-value 0.0305553
Overlap 7
Offset 0
Orientation Reverse Complement
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Matches to Query: 11_e_k36me3_193_0.378

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Matches to Query: 12_e_k27me3_327_0.619

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Matches to Query: 13_e_k9me3_208_0.386

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Summary 

Alignment 

Name AP4_Q6_M00176_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.21109e-05
E-value 0.0353758
q-value 0.0706203
Overlap 9
Offset 1
Orientation Reverse Complement
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Matches to Query: 14_e_k9me3_26_0.386

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Matches to Query: 15_e_k36me3_169_0.409

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Matches to Query: 16_e_k27ac_106_0.410

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Summary 

Alignment 

Name MAF_Q6_01_M00983_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.88151e-06
E-value 0.0142589
q-value 0.0223056
Overlap 9
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name NFE2_01_M00037_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.66504e-06
E-value 0.0223896
q-value 0.0223056
Overlap 9
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name NRF2_Q4_M00821_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50691e-05
E-value 0.0440169
q-value 0.0260312
Overlap 9
Offset 3
Orientation Reverse Complement
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Matches to Query: 17_e_k4me1_75_0.415

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Matches to Query: 18_e_k4me1_503_0.417

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Matches to Query: 19_e_k36me3_152_0.430

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Matches to Query: 20_h_k36me3_19_0.538

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 53.577 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.