TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_k36me3_125_0.416
GTCTCAAAAAA
0
2_e_k4me1_243_0.570
ATGTATGCA
0
3_e_k36me3_26_0.432
GGCGTGAGCC
0
4_e_k36me3_29_0.433
TGGTGGCTCA
0
5_e_k4me3_73_0.434
AAGATGGCG
1 REX1_03_M01744_T
6_e_k4me3_273_0.437
AAAACGAAAG
0
7_e_k27me3_6_0.437
CGCGCCCCG
0
8_e_k36me3_13_0.439
AACCCCGTC
0
9_h_k4me3_1_0.440
CCGGAAGCAA
24 ELK1_02_M00025_T,  ELF2_10_H,  Ehf_EMBO10_U,  ETV4_13_H,  Ehf_primary_SCI09_U,  Ets1_EMBO10_U,  Eip74EF_MA0026.1_J,  CETS1P54_03_M01078_T,  Elk3_EMBO10_U,  Elf3_EMBO10_U
10_e_k36me3_106_0.441
AGGCTGGTC
2 SMAP1L_4_H,  TRIM21_5_H
11_e_k4me1_208_0.557
TCACATGCA
4 INO2_MA0321.1_J,  INO2_01_M01671_T,  INO4_MA0322.1_J,  INO4_01_M01689_T
12_e_k4me1_503_0.556
CATTTGGCA
0
13_e_k36me3_4_0.445
ACAGGCGTGGT
0
14_e_k36me3_72_0.447
CCTGACCTCGT
0
15_e_k4me1_292_0.552
CAGTGTGAC
0
16_e_k36me3_21_0.448
CTGGGCAACAG
0
17_e_k9me3_17_0.551
GACACATCAC
0
18_e_k36me3_24_0.450
AGGAGTTCG
1 RPC155_01_M01798_T
19_e_k4me1_310_0.544
AATCAGCAT
0
20_e_k4me1_379_0.543
CTGCACATCC
0
21_e_k4me1_193_0.542
AGCAGGCAG
0
22_e_k4me1_468_0.541
TGCTTTGAA
0
23_e_k4me3_202_0.460
ACTCGGAA
0
24_e_k4me1_46_0.539
AAGCACTACGT
0
25_e_k27me3_176_0.461
AGATAAACG
0
26_h_k27ac_5_0.464
GACTCAGCCCGC
0
27_e_k9me3_3_0.468
GCGCTCCAA
0
28_e_k9me3_118_0.528
AGCTGTAGA
0
29_e_k36me3_136_0.527
CCGTGTTAG
0
30_e_k9me3_29_0.481
AATCACCCGTC
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 32

Matches to Query: 1_e_k36me3_125_0.416

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Matches to Query: 2_e_k4me1_243_0.570

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Matches to Query: 3_e_k36me3_26_0.432

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Matches to Query: 4_e_k36me3_29_0.433

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Matches to Query: 5_e_k4me3_73_0.434

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Summary 

Alignment 

Name REX1_03_M01744_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.0053e-05
E-value 0.0293648
q-value 0.0587295
Overlap 9
Offset 0
Orientation Normal
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Matches to Query: 6_e_k4me3_273_0.437

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Matches to Query: 7_e_k27me3_6_0.437

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Matches to Query: 8_e_k36me3_13_0.439

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Matches to Query: 9_h_k4me3_1_0.440

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Summary 

Alignment 

Name ELK1_02_M00025_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.5833e-08
E-value 0.000192298
q-value 0.000375612
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name ELF2_10_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.31333e-07
E-value 0.00125992
q-value 0.00101724
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Ehf_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.3487e-07
E-value 0.00156236
q-value 0.00101724
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ETV4_13_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.28246e-07
E-value 0.00241931
q-value 0.00112232
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Ehf_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.06751e-06
E-value 0.00311819
q-value 0.00112232
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Ets1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.18025e-06
E-value 0.0034475
q-value 0.00112232
Overlap 10
Offset 6
Orientation Normal
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Summary 

Alignment 

Name Eip74EF_MA0026.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.95436e-06
E-value 0.00570868
q-value 0.00151015
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name CETS1P54_03_M01078_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.11745e-06
E-value 0.00618508
q-value 0.00151015
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Elk3_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.86261e-06
E-value 0.00836169
q-value 0.00181475
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Elf3_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.37811e-06
E-value 0.00986746
q-value 0.00192739
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Elk4_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.08292e-06
E-value 0.0119262
q-value 0.00207786
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name E74A_01_M00016_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.65627e-06
E-value 0.013601
q-value 0.00207786
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name GABPA_MA0062.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.73438e-06
E-value 0.0138291
q-value 0.00207786
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Gm4881_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.64661e-06
E-value 0.0252567
q-value 0.00330451
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ETS_class_MF0001.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.18531e-06
E-value 0.0268303
q-value 0.00330451
Overlap 7
Offset 1
Orientation Normal
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Summary 

Alignment 

Name Etv1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.84601e-06
E-value 0.0287602
q-value 0.00330451
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Etv6_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.84601e-06
E-value 0.0287602
q-value 0.00330451
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Elk1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.13438e-05
E-value 0.0331352
q-value 0.00359568
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Sip4_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.34442e-05
E-value 0.0392706
q-value 0.00367982
Overlap 10
Offset 8
Orientation Reverse Complement
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Summary 

Alignment 

Name SAP1A_01_M01167_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.37731e-05
E-value 0.0402312
q-value 0.00367982
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Erg_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50386e-05
E-value 0.0439279
q-value 0.00367982
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Fli1_EMBO10_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.50386e-05
E-value 0.0439279
q-value 0.00367982
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ERG_01_M01752_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.53187e-05
E-value 0.0447459
q-value 0.00367982
Overlap 8
Offset 1
Orientation Normal
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Summary 

Alignment 

Name SIP4_01_M01517_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.5479e-05
E-value 0.0452141
q-value 0.00367982
Overlap 10
Offset 8
Orientation Reverse Complement
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Matches to Query: 10_e_k36me3_106_0.441

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Summary 

Alignment 

Name SMAP1L_4_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.03746e-06
E-value 0.0263984
q-value 0.0434922
Overlap 6
Offset -1
Orientation Normal
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Summary 

Alignment 

Name TRIM21_5_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.48895e-05
E-value 0.0434922
q-value 0.0434922
Overlap 6
Offset -1
Orientation Normal
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Matches to Query: 11_e_k4me1_208_0.557

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Summary 

Alignment 

Name INO2_MA0321.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.05676e-06
E-value 0.0235338
q-value 0.0178545
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name INO2_01_M01671_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.75704e-06
E-value 0.0255793
q-value 0.0178545
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name INO4_MA0322.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.03524e-05
E-value 0.0302394
q-value 0.0178545
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name INO4_01_M01689_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.22249e-05
E-value 0.035709
q-value 0.0178545
Overlap 8
Offset 1
Orientation Reverse Complement
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Matches to Query: 12_e_k4me1_503_0.556

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Matches to Query: 13_e_k36me3_4_0.445

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Matches to Query: 14_e_k36me3_72_0.447

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Matches to Query: 15_e_k4me1_292_0.552

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Matches to Query: 16_e_k36me3_21_0.448

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Matches to Query: 17_e_k9me3_17_0.551

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Matches to Query: 18_e_k36me3_24_0.450

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.3742e-05
E-value 0.0401403
q-value 0.0802807
Overlap 9
Offset 2
Orientation Normal
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Matches to Query: 19_e_k4me1_310_0.544

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Matches to Query: 20_e_k4me1_379_0.543

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Matches to Query: 21_e_k4me1_193_0.542

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Matches to Query: 22_e_k4me1_468_0.541

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Matches to Query: 23_e_k4me3_202_0.460

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Matches to Query: 24_e_k4me1_46_0.539

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Matches to Query: 25_e_k27me3_176_0.461

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Matches to Query: 26_h_k27ac_5_0.464

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Matches to Query: 27_e_k9me3_3_0.468

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Matches to Query: 28_e_k9me3_118_0.528

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Matches to Query: 29_e_k36me3_136_0.527

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Matches to Query: 30_e_k9me3_29_0.481

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 78.830 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.