TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_re_88_0.435
CTGAGGCTCA
0
2_h_1_0.562
TTGTCATGCAAA
4 OCT4_01_M01125_T,  Pou5f1_MA0142.1_J,  Sox2_MA0143.1_J,  OCT4_02_M01124_T
3_re_10_0.448
AATAAATAT
1 CROC_01_M00266_T
4_re_63_0.452
GAGGACAGA
0
5_re_42_0.456
GCCTGGCAC
0
6_h_2_0.544
GTAATTAGCA
2 IPF1_06_M01438_T,  Ipf1_3815.1_Cell08_U
7_re_59_0.458
CTCTTCCTC
0
8_re_16_0.458
CGTGGCTGCCT
0
9_re_78_0.458
AATATAAAAT
0
10_re_20_0.459
AGAAAATAAA
0
11_re_100_0.460
GCTGTGGCCT
2 MET28_01_M01674_T,  MET28_MA0332.1_J
12_re_23_0.461
TATTTTTAA
2 MEF2_05_M01301_T,  AMEF2_Q6_M00403_T
13_re_102_0.461
GGCAGAGCC
0
14_re_30_0.461
ATACGTAAAGA
0
15_re_56_0.466
CAGGCACTG
0
16_re_55_0.467
GGGCAGGGAC
0
17_re_21_0.467
ACAGAGAAAGTG
0
18_re_0_0.467
CACGTGGCCT
15 PIF3_01_M00434_T,  PIF3_02_M00435_T,  ABF1_02_M00400_T,  GBF_Q2_M00441_T,  ABF_Q2_M00442_T,  CBF1_02_M01699_T,  USF_01_M00121_T,  CG1_Q6_M00440_T,  Arnt_MA0004.1_J,  Mycn_MA0104.1_J
19_e_218_0.533
AAAGCATTTA
0
20_e_107_0.532
TAAAATGCA
1 SSX2_8_H
21_re_72_0.468
AGAAACAGAA
0
22_re_58_0.468
CCTCTTCCCTC
0
23_re_83_0.469
TCGTCTCCTC
0
24_re_17_0.470
GAGAAGAAA
0
25_re_39_0.470
CTCAGTTTC
0
26_re_87_0.472
CCACGCTGCC
1 HLCS_2_H
27_re_109_0.474
CACCGTGGG
0
28_e_95_0.526
TGCTAAGCAAG
0
29_re_111_0.475
AGCTCCACG
0
30_h_16_0.525
GCGTAACA
0
31_re_48_0.475
ATGAGAAAA
0
32_h_24_0.524
CAAATTCG
0
33_re_49_0.477
CAGAGCTGGG
0
34_re_69_0.477
ACGTGGTAGG
0
35_h_20_0.523
AAACACGCTT
0
36_re_101_0.477
ATACGTTTA
0
37_re_47_0.477
ACCTCTCTGG
0
38_re_60_0.478
AGGACACGGTA
0
39_e_411_0.522
GCTAATGAA
0
40_e_505_0.521
CATTAACAC
0
41_h_27_0.520
ACTGGCAGTTAA
0
42_e_298_0.518
CAGCAGTTA
0
43_h_22_0.518
CAAAGCACAGTT
0
44_e_88_0.518
GCATGCACA
0
45_h_33_0.517
AACCAGTTCATT
0
46_re_54_0.483
ACAGATGAGA
0
47_e_180_0.517
AAACATTTCC
2 SCMH1_9_H,  BCL11A_7_H
48_e_290_0.516
GCATTCAGCAC
0
49_h_19_0.516
AAGGCGCATT
0
50_e_416_0.515
AATGCTGAC
1 Mafk_primary_SCI09_U
51_h_6_0.515
GCTTTCCAGCAG
0
52_e_376_0.515
CTCATTTAA
0
53_e_278_0.514
TGTAAATAACGC
2 FOXO3A_Q1_M01137_T,  DAF16_01_M00475_T
54_h_5_0.514
TTAACCACAC
0
55_e_172_0.514
CCTGCATTTC
0
56_e_363_0.514
GTAAATGGA
0
57_re_37_0.487
ACGTTTTCT
0
58_re_81_0.487
CACTTCTGCG
0
59_e_49_0.513
CCGTTACT
0
60_e_342_0.513
AGCAAATATT
0
61_e_304_0.513
CACAGGTAA
1 AREB6_01_M00412_T
62_e_338_0.513
ATTTACTGA
0
63_e_224_0.513
ACAGTATGTT
0
64_re_18_0.489
GTCAGCACCTAC
0
65_h_11_0.511
TGCTACCTGCTG
0
66_e_192_0.511
TGAATGTGCC
0
67_e_453_0.511
ATGAATGCC
0
68_e_206_0.510
GCCGTTCAC
0
69_e_490_0.510
CTGCATAAA
0
70_h_10_0.510
CTCTAAAGGGAG
0
71_h_4_0.510
TTAACGCC
0
72_e_264_0.510
TAAATGTCAG
0
73_e_402_0.510
CTGTTTTGC
0
74_e_335_0.510
AAGTCACTT
0
75_re_57_0.491
ACACATACG
0
76_e_372_0.509
ACAGGAAGT
5 ETS2_B_M00340_T,  ETS1_B_M00339_T,  ELK1_01_M00007_T,  TEL2_Q6_M00678_T,  ETS_Q6_M00971_T
77_e_350_0.509
TATGTAGCA
0
78_e_291_0.509
ATACACAGC
0
79_e_195_0.509
GAAAACACAT
0
80_re_93_0.492
AACGTAAGTAT
0
81_re_52_0.492
GACGTACATA
0
82_e_69_0.507
AACGAGGTG
0
83_h_29_0.507
AAACAACG
0
84_e_385_0.506
ACAAAGGCA
0
85_e_53_0.505
TCGGTGTCAG
0
86_re_24_0.496
CACGTAGTA
0
87_e_424_0.503
AGCTCACAGA
0
88_e_222_0.502
ACAGTGTAC
0
89_e_293_0.502
AAATCGCAGG
0
90_e_355_0.501
GCCACTTAA
3 NKX26_01_M01322_T,  Nkx2-6_3437.1_Cell08_U,  Nkx3-1_primary_SCI09_U

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 42

Matches to Query: 1_re_88_0.435

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Matches to Query: 2_h_1_0.562

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Summary 

Alignment 

Name OCT4_01_M01125_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.79663e-13
E-value 1.6932e-09
q-value 3.36554e-09
Overlap 12
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Pou5f1_MA0142.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.42557e-11
E-value 4.16409e-08
q-value 4.13845e-08
Overlap 12
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Sox2_MA0143.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.12541e-08
E-value 6.20832e-05
q-value 4.11339e-05
Overlap 12
Offset 3
Orientation Normal
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Summary 

Alignment 

Name OCT4_02_M01124_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.12804e-07
E-value 0.0006216
q-value 0.000308886
Overlap 12
Offset 1
Orientation Normal
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Matches to Query: 3_re_10_0.448

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Summary 

Alignment 

Name CROC_01_M00266_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.0011e-06
E-value 0.0116872
q-value 0.023267
Overlap 9
Offset 3
Orientation Normal
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Matches to Query: 4_re_63_0.452

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Matches to Query: 5_re_42_0.456

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Matches to Query: 6_h_2_0.544

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Summary 

Alignment 

Name IPF1_06_M01438_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.13837e-05
E-value 0.0332519
q-value 0.0182131
Overlap 10
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Ipf1_3815.1_Cell08_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.13837e-05
E-value 0.0332519
q-value 0.0182131
Overlap 10
Offset 3
Orientation Normal
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Matches to Query: 7_re_59_0.458

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Matches to Query: 8_re_16_0.458

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Matches to Query: 9_re_78_0.458

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Matches to Query: 10_re_20_0.459

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Matches to Query: 11_re_100_0.460

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Summary 

Alignment 

Name MET28_01_M01674_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.90517e-06
E-value 0.00848599
q-value 0.00848484
Overlap 6
Offset -1
Orientation Normal
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Summary 

Alignment 

Name MET28_MA0332.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.90517e-06
E-value 0.00848599
q-value 0.00848484
Overlap 6
Offset -1
Orientation Normal
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Matches to Query: 12_re_23_0.461

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Summary 

Alignment 

Name MEF2_05_M01301_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.93779e-06
E-value 0.0231863
q-value 0.0370365
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name AMEF2_Q6_M00403_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.43273e-05
E-value 0.0418499
q-value 0.0370365
Overlap 9
Offset 5
Orientation Reverse Complement
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Matches to Query: 13_re_102_0.461

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Matches to Query: 14_re_30_0.461

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Matches to Query: 15_re_56_0.466

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Matches to Query: 16_re_55_0.467

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Matches to Query: 17_re_21_0.467

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Matches to Query: 18_re_0_0.467

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Summary 

Alignment 

Name PIF3_01_M00434_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.01626e-07
E-value 0.00058895
q-value 0.00113478
Overlap 10
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name PIF3_02_M00435_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 9.63881e-07
E-value 0.0028155
q-value 0.00271243
Overlap 10
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name ABF1_02_M00400_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.17493e-06
E-value 0.00635298
q-value 0.00341956
Overlap 10
Offset 10
Orientation Normal
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Summary 

Alignment 

Name GBF_Q2_M00441_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.63468e-06
E-value 0.00769589
q-value 0.00341956
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name ABF_Q2_M00442_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.71284e-06
E-value 0.0108452
q-value 0.00341956
Overlap 10
Offset 5
Orientation Normal
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Summary 

Alignment 

Name CBF1_02_M01699_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.95925e-06
E-value 0.011565
q-value 0.00341956
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name USF_01_M00121_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 5.6735e-06
E-value 0.0165723
q-value 0.00341956
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name CG1_Q6_M00440_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.83433e-06
E-value 0.0228841
q-value 0.00341956
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Arnt_MA0004.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.89577e-06
E-value 0.0230636
q-value 0.00341956
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.89577e-06
E-value 0.0230636
q-value 0.00341956
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name USF1_MA0093.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.89857e-06
E-value 0.0230717
q-value 0.00341956
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name EMBP1_Q2_M00366_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.24883e-05
E-value 0.0364783
q-value 0.00485305
Overlap 8
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name CMYC_02_M01154_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.31571e-05
E-value 0.038432
q-value 0.00485305
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name GBP_Q6_M00182_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.42862e-05
E-value 0.0417299
q-value 0.00485305
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name Mycn_MA0104.2_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.46926e-05
E-value 0.042917
q-value 0.00485305
Overlap 8
Offset 2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 19_e_218_0.533

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Matches to Query: 20_e_107_0.532

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Summary 

Alignment 

Name SSX2_8_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.03231e-06
E-value 0.0205414
q-value 0.0410772
Overlap 8
Offset -1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 21_re_72_0.468

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Matches to Query: 22_re_58_0.468

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Matches to Query: 23_re_83_0.469

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Matches to Query: 24_re_17_0.470

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Matches to Query: 25_re_39_0.470

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Matches to Query: 26_re_87_0.472

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Summary 

Alignment 

Name HLCS_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.06871e-05
E-value 0.0312172
q-value 0.0624343
Overlap 5
Offset -5
Orientation Reverse Complement
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Matches to Query: 27_re_109_0.474

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Matches to Query: 28_e_95_0.526

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Matches to Query: 29_re_111_0.475

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Matches to Query: 30_h_16_0.525

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Matches to Query: 31_re_48_0.475

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Matches to Query: 32_h_24_0.524

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Matches to Query: 33_re_49_0.477

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Matches to Query: 34_re_69_0.477

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Matches to Query: 35_h_20_0.523

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Matches to Query: 36_re_101_0.477

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Matches to Query: 37_re_47_0.477

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Matches to Query: 38_re_60_0.478

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Matches to Query: 39_e_411_0.522

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Matches to Query: 40_e_505_0.521

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Matches to Query: 41_h_27_0.520

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Matches to Query: 42_e_298_0.518

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Matches to Query: 43_h_22_0.518

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Matches to Query: 44_e_88_0.518

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Matches to Query: 45_h_33_0.517

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Matches to Query: 46_re_54_0.483

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Matches to Query: 47_e_180_0.517

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Summary 

Alignment 

Name SCMH1_9_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.74102e-06
E-value 0.0226115
q-value 0.0379859
Overlap 6
Offset -3
Orientation Reverse Complement
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Summary 

Alignment 

Name BCL11A_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.30106e-05
E-value 0.0380041
q-value 0.0379859
Overlap 6
Offset -3
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 48_e_290_0.516

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Matches to Query: 49_h_19_0.516

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Matches to Query: 50_e_416_0.515

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Summary 

Alignment 

Name Mafk_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.36601e-06
E-value 0.0215161
q-value 0.0430322
Overlap 9
Offset 4
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 51_h_6_0.515

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Matches to Query: 52_e_376_0.515

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Matches to Query: 53_e_278_0.514

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Summary 

Alignment 

Name FOXO3A_Q1_M01137_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.64486e-05
E-value 0.0480463
q-value 0.0475782
Overlap 12
Offset 0
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name DAF16_01_M00475_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.70274e-05
E-value 0.0497371
q-value 0.0475782
Overlap 12
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 54_h_5_0.514

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Matches to Query: 55_e_172_0.514

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Matches to Query: 56_e_363_0.514

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Matches to Query: 57_re_37_0.487

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Matches to Query: 58_re_81_0.487

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Matches to Query: 59_e_49_0.513

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Matches to Query: 60_e_342_0.513

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Matches to Query: 61_e_304_0.513

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Summary 

Alignment 

Name AREB6_01_M00412_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.27541e-06
E-value 0.0183305
q-value 0.0366609
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 62_e_338_0.513

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Matches to Query: 63_e_224_0.513

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Matches to Query: 64_re_18_0.489

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Matches to Query: 65_h_11_0.511

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Matches to Query: 66_e_192_0.511

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Matches to Query: 67_e_453_0.511

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Matches to Query: 68_e_206_0.510

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Matches to Query: 69_e_490_0.510

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Matches to Query: 70_h_10_0.510

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Matches to Query: 71_h_4_0.510

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Matches to Query: 72_e_264_0.510

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Matches to Query: 73_e_402_0.510

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Matches to Query: 74_e_335_0.510

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Matches to Query: 75_re_57_0.491

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Matches to Query: 76_e_372_0.509

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Summary 

Alignment 

Name ETS2_B_M00340_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.07393e-07
E-value 0.0020663
q-value 0.00409648
Overlap 9
Offset 1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name ETS1_B_M00339_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.70542e-06
E-value 0.0108235
q-value 0.010729
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ELK1_01_M00007_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.85223e-06
E-value 0.0200154
q-value 0.013227
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name TEL2_Q6_M00678_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.56557e-05
E-value 0.0457304
q-value 0.0179578
Overlap 8
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name ETS_Q6_M00971_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.69004e-05
E-value 0.049366
q-value 0.0179578
Overlap 8
Offset -1
Orientation Reverse Complement
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Matches to Query: 77_e_350_0.509

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Matches to Query: 78_e_291_0.509

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Matches to Query: 79_e_195_0.509

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Matches to Query: 80_re_93_0.492

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Matches to Query: 81_re_52_0.492

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Matches to Query: 82_e_69_0.507

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Matches to Query: 83_h_29_0.507

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Matches to Query: 84_e_385_0.506

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Matches to Query: 85_e_53_0.505

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Matches to Query: 86_re_24_0.496

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Matches to Query: 87_e_424_0.503

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Matches to Query: 88_e_222_0.502

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Matches to Query: 89_e_293_0.502

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Matches to Query: 90_e_355_0.501

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Summary 

Alignment 

Name NKX26_01_M01322_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.18814e-05
E-value 0.0347056
q-value 0.0286064
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Nkx2-6_3437.1_Cell08_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.43756e-05
E-value 0.0419911
q-value 0.0286064
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Nkx3-1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.47021e-05
E-value 0.042945
q-value 0.0286064
Overlap 9
Offset 4
Orientation Normal
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 242.326 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.