TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

1_e_2_0.573
CCGCCGCCG
1 ERF2_01_M01057_T
2_h_6_0.573
CTTTTCCG
0
3_h_1_0.572
TTGTTATGCAAA
5 OCT4_01_M01125_T,  Pou5f1_MA0142.1_J,  Sox2_MA0143.1_J,  OCT4_02_M01124_T,  NFIX_2_H
4_h_15_0.571
CGTTACGG
0
5_re_80_0.430
ATGTGCCAG
0
6_re_63_0.433
AGCACAGTG
0
7_e_6_0.564
CCGCCCGCCT
0
8_re_85_0.438
CTGAGGCTCA
0
9_re_106_0.441
AGGTCACAC
0
10_re_26_0.441
ACACACATGC
0
11_re_4_0.444
ACGTGGCCT
3 BZIP911_01_M00358_T,  PIF3_01_M00434_T,  XBP1_02_M01770_T
12_e_26_0.555
ATGCGCGTC
0
13_e_19_0.555
AGCGCCGCG
0
14_re_86_0.446
ACATGTGCT
0
15_e_29_0.554
CGGAAGTCG
2 RARG_9_H,  FLI1_7_H
16_re_11_0.446
CTGTGTGTCT
0
17_re_100_0.446
CAGATGAGG
0
18_re_109_0.447
ACTGTGCTA
0
19_e_31_0.551
CCGCCCCGG
0
20_e_163_0.551
GGACTCGG
0
21_e_11_0.550
TCGCGGAGAG
1 NRSE_B_M00325_T
22_e_252_0.549
AAACAAAAC
0
23_re_29_0.452
CAGAGCTGGGA
0
24_e_201_0.547
AAAAACGTTT
0
25_e_12_0.547
ACGGCGCGCA
0
26_e_371_0.545
CCGTAATAA
0
27_e_14_0.545
CTCGCGAGACT
0
28_re_98_0.457
AGAACGTGGCA
0
29_re_107_0.458
GCAGAGCCA
0
30_re_38_0.460
ACACAGCAGT
0
31_e_359_0.540
ATGTAAATC
1 Ypr013c_GR09_U
32_e_253_0.539
TCCCGTTTTA
0
33_h_13_0.539
GGAATTCCGA
0
34_e_291_0.538
AAGAAACGT
0
35_e_221_0.538
AAAGGAAAAA
1 HELIOSA_02_M01004_T
36_re_66_0.463
CATGTAGTA
0
37_h_27_0.533
TTTACCGCTC
0
38_re_79_0.467
ATGCAGGTA
0
39_e_89_0.532
CGGAGACCG
0
40_e_352_0.532
ATACGGTAA
0
41_e_333_0.529
TACGGAGTA
0
42_e_383_0.528
GAAAATTAC
1 HOXD3_3_H
43_e_362_0.525
GGAAACCAG
0
44_e_137_0.522
CAGCTACGT
0
45_e_299_0.520
ACGCTCGTC
0
46_e_375_0.518
AGGTGAAAT
0
47_re_20_0.483
CATTCATTC
1 Hbp1_primary_SCI09_U
48_e_312_0.508
GGTAGGTAA
0
49_h_14_0.507
ACTTCTTTTGTG
0
50_e_317_0.505
GATACGAG
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiCmbned3.meme 2921 16

Matches to Query: 1_e_2_0.573

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Summary 

Alignment 

Name ERF2_01_M01057_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.62326e-07
E-value 0.00251885
q-value 0.00499888
Overlap 7
Offset -1
Orientation Normal
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Matches to Query: 2_h_6_0.573

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Matches to Query: 3_h_1_0.572

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Summary 

Alignment 

Name OCT4_01_M01125_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 2.33079e-14
E-value 6.80824e-11
q-value 1.35373e-10
Overlap 12
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Pou5f1_MA0142.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 3.67671e-13
E-value 1.07397e-09
q-value 1.06772e-09
Overlap 12
Offset 2
Orientation Normal
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Summary 

Alignment 

Name Sox2_MA0143.1_J
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.20139e-09
E-value 1.22723e-05
q-value 8.13395e-06
Overlap 12
Offset 3
Orientation Normal
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Summary 

Alignment 

Name OCT4_02_M01124_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.4685e-08
E-value 4.28949e-05
q-value 2.13228e-05
Overlap 12
Offset 1
Orientation Normal
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Summary 

Alignment 

Name NFIX_2_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.66944e-05
E-value 0.0487644
q-value 0.0193924
Overlap 6
Offset -6
Orientation Normal
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Matches to Query: 4_h_15_0.571

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Matches to Query: 5_re_80_0.430

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Matches to Query: 6_re_63_0.433

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Matches to Query: 7_e_6_0.564

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Matches to Query: 8_re_85_0.438

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Matches to Query: 9_re_106_0.441

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Matches to Query: 10_re_26_0.441

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Matches to Query: 11_re_4_0.444

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Summary 

Alignment 

Name BZIP911_01_M00358_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.14249e-05
E-value 0.0333721
q-value 0.0276303
Overlap 8
Offset 4
Orientation Normal
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Summary 

Alignment 

Name PIF3_01_M00434_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.33246e-05
E-value 0.0389211
q-value 0.0276303
Overlap 9
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name XBP1_02_M01770_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.46258e-05
E-value 0.042722
q-value 0.0276303
Overlap 9
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 12_e_26_0.555

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Matches to Query: 13_e_19_0.555

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Matches to Query: 14_re_86_0.446

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Matches to Query: 15_e_29_0.554

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Summary 

Alignment 

Name RARG_9_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 6.55254e-06
E-value 0.01914
q-value 0.037873
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name FLI1_7_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.5067e-05
E-value 0.0440108
q-value 0.043543
Overlap 7
Offset 0
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: 16_re_11_0.446

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Matches to Query: 17_re_100_0.446

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Matches to Query: 18_re_109_0.447

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Matches to Query: 19_e_31_0.551

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Matches to Query: 20_e_163_0.551

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Matches to Query: 21_e_11_0.550

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Summary 

Alignment 

Name NRSE_B_M00325_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.37804e-05
E-value 0.0402526
q-value 0.0805052
Overlap 10
Offset 7
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 22_e_252_0.549

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Matches to Query: 23_re_29_0.452

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Matches to Query: 24_e_201_0.547

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Matches to Query: 25_e_12_0.547

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Matches to Query: 26_e_371_0.545

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Matches to Query: 27_e_14_0.545

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Matches to Query: 28_re_98_0.457

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Matches to Query: 29_re_107_0.458

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Matches to Query: 30_re_38_0.460

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Matches to Query: 31_e_359_0.540

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Summary 

Alignment 

Name Ypr013c_GR09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 1.64873e-05
E-value 0.0481593
q-value 0.0541457
Overlap 9
Offset 4
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 32_e_253_0.539

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Matches to Query: 33_h_13_0.539

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Matches to Query: 34_e_291_0.538

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Matches to Query: 35_e_221_0.538

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Summary 

Alignment 

Name HELIOSA_02_M01004_T
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 8.66025e-06
E-value 0.0252966
q-value 0.0504296
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: 36_re_66_0.463

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Matches to Query: 37_h_27_0.533

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Matches to Query: 38_re_79_0.467

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Matches to Query: 39_e_89_0.532

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Matches to Query: 40_e_352_0.532

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Matches to Query: 41_e_333_0.529

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Matches to Query: 42_e_383_0.528

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Summary 

Alignment 

Name HOXD3_3_H
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 7.35558e-06
E-value 0.0214856
q-value 0.0425273
Overlap 7
Offset -2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 43_e_362_0.525

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Matches to Query: 44_e_137_0.522

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Matches to Query: 45_e_299_0.520

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Matches to Query: 46_e_375_0.518

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Matches to Query: 47_re_20_0.483

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Summary 

Alignment 

Name Hbp1_primary_SCI09_U
Database trnsfcJsprUnprobHpdiCmbned3.meme
p-value 4.36177e-06
E-value 0.0127407
q-value 0.0254814
Overlap 9
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: 48_e_312_0.508

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Matches to Query: 49_h_14_0.507

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Matches to Query: 50_e_317_0.505

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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 119.421 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.