TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

h115-k27ac-33_h_13_0.539
GGAATTCCGA
0
mes15-k27ac-23_h_8_0.544
AGGAATGCGA
7 TEAD1_dimeric_0_P,  TEAD4_monomeric_0_P,  TEAD3_dimeric_0_P,  TEC1_MA0406.1_J,  TEAD1_monomeric_0_P,  Bcl6b_primary_SCI09_U,  Tec1_GR09_U
mes17-k27ac-27_e_k27ac_82_0.543
CCACATTCC
0
msc15-k27ac-5_h_2_0.551
GCATTCCAGAGA
8 TEAD3_monomeric_0_P,  TEAD1_dimeric_0_P,  TEAD3_dimeric_0_P,  ABAA_01_M00027_T,  TEAD4_monomeric_0_P,  TEAD1_monomeric_0_P,  TEAD1_MA0090.1_J,  TEF_01_M01305_T
msc20-k27ac-29_h_2_0.568
ACATTCCTGAGA
8 ABAA_01_M00027_T,  TEAD4_monomeric_0_P,  TEAD3_dimeric_0_P,  TEAD3_monomeric_0_P,  TEAD1_dimeric_0_P,  TEAD1_monomeric_0_P,  TEAD1_MA0090.1_J,  TEF_01_M01305_T
npc17-k36me3-25_h_k27ac_19_0.453
ACATTCCGCG
0
npc20-k27ac-47_e_128_0.541
CCACATTCC
0
tro15-k27ac-1_h_2_0.564
ACATTCCT
8 TEAD4_monomeric_0_P,  TEAD3_monomeric_0_P,  TEAD1_dimeric_0_P,  TEAD1_monomeric_0_P,  TEAD3_dimeric_0_P,  TEAD1_MA0090.1_J,  TEF_01_M01305_T,  ABAA_01_M00027_T
tro15-k4me1-2_e_86_0.529
ACATTCCAG
2 HNRPH3_9_H,  TEAD3_monomeric_0_P
tro15-k4me1-5_h_2_0.520
CACATTCCTT
4 TEAD1_monomeric_0_P,  TEAD4_monomeric_0_P,  TEAD1_MA0090.1_J,  TEF_01_M01305_T
tro15-k4me1-7_e_31_0.516
AGGAATGTG
4 TEAD1_MA0090.1_J,  TEF_01_M01305_T,  TEAD1_monomeric_0_P,  TEAD4_monomeric_0_P
tro17-k27ac-2_h_k4me1_1_0.548
ACAGGAATTC
4 TEAD4_monomeric_0_P,  TEAD1_dimeric_0_P,  TEAD3_dimeric_0_P,  TEAD1_monomeric_0_P
tro20-k27ac-14_h_2_0.592
CCACATTCCT
8 TEAD1_monomeric_0_P,  TEAD4_monomeric_0_P,  TEAD3_dimeric_0_P,  TEAD1_MA0090.1_J,  TEF_01_M01305_T,  TEAD1_dimeric_0_P,  TEAD3_monomeric_0_P,  ABAA_01_M00027_T

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiTaipaleCmbned.meme 3764 12

Matches to Query: h115-k27ac-33_h_13_0.539

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Matches to Query: mes15-k27ac-23_h_8_0.544

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Summary 

Alignment 

Name TEAD1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.90656e-07
E-value 0.00109403
q-value 0.00157263
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.17808e-07
E-value 0.00157263
q-value 0.00157263
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD3_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.45314e-06
E-value 0.00546963
q-value 0.00307539
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name TEC1_MA0406.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.63411e-06
E-value 0.00615078
q-value 0.00307539
Overlap 8
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.58294e-06
E-value 0.0097222
q-value 0.00388888
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name Bcl6b_primary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.83832e-05
E-value 0.0691943
q-value 0.0230648
Overlap 9
Offset 7
Orientation Normal
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Summary 

Alignment 

Name Tec1_GR09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.47544e-05
E-value 0.0931754
q-value 0.0240514
Overlap 10
Offset 6
Orientation Reverse Complement
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Matches to Query: mes17-k27ac-27_e_k27ac_82_0.543

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Matches to Query: msc15-k27ac-5_h_2_0.551

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Summary 

Alignment 

Name TEAD3_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.4519e-07
E-value 0.000546496
q-value 0.00109299
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.87861e-07
E-value 0.00145991
q-value 0.00131198
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD3_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.22842e-07
E-value 0.00196798
q-value 0.00131198
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name ABAA_01_M00027_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.0378e-06
E-value 0.00767029
q-value 0.00383515
Overlap 12
Offset 6
Orientation Normal
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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.93844e-06
E-value 0.0148243
q-value 0.00592971
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.07547e-06
E-value 0.0266321
q-value 0.00887736
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.32281e-05
E-value 0.0497905
q-value 0.0124476
Overlap 11
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.32281e-05
E-value 0.0497905
q-value 0.0124476
Overlap 11
Offset 1
Orientation Normal
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Matches to Query: msc20-k27ac-29_h_2_0.568

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Summary 

Alignment 

Name ABAA_01_M00027_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.24836e-07
E-value 0.000469884
q-value 0.000939096
Overlap 12
Offset 6
Orientation Normal
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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.10354e-07
E-value 0.00192097
q-value 0.00160778
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEAD3_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.4118e-07
E-value 0.0024134
q-value 0.00160778
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD3_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.13137e-07
E-value 0.00343705
q-value 0.00171729
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.19135e-06
E-value 0.00448423
q-value 0.00179241
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.50076e-06
E-value 0.00564885
q-value 0.0018816
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.0132e-06
E-value 0.0188697
q-value 0.00471405
Overlap 11
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.0132e-06
E-value 0.0188697
q-value 0.00471405
Overlap 11
Offset 1
Orientation Normal
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Matches to Query: npc17-k36me3-25_h_k27ac_19_0.453

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Matches to Query: npc20-k27ac-47_e_128_0.541

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Matches to Query: tro15-k27ac-1_h_2_0.564

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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.39354e-08
E-value 0.000127733
q-value 0.000170779
Overlap 8
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEAD3_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.52413e-08
E-value 0.000207928
q-value 0.000170779
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.98925e-08
E-value 0.000300715
q-value 0.000170779
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.07435e-08
E-value 0.000341559
q-value 0.000170779
Overlap 8
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEAD3_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.20214e-07
E-value 0.000828884
q-value 0.000331554
Overlap 8
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.67418e-07
E-value 0.00138296
q-value 0.000395132
Overlap 8
Offset 1
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.67418e-07
E-value 0.00138296
q-value 0.000395132
Overlap 8
Offset 1
Orientation Normal
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Summary 

Alignment 

Name ABAA_01_M00027_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.0775e-05
E-value 0.0781971
q-value 0.0195493
Overlap 8
Offset 6
Orientation Normal
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Matches to Query: tro15-k4me1-2_e_86_0.529

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Summary 

Alignment 

Name HNRPH3_9_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.49216e-05
E-value 0.056165
q-value 0.069406
Overlap 6
Offset -3
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD3_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.84394e-05
E-value 0.069406
q-value 0.069406
Overlap 8
Offset 0
Orientation Normal
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Matches to Query: tro15-k4me1-5_h_2_0.520

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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.02672e-09
E-value 2.64486e-05
q-value 3.58276e-05
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.51848e-09
E-value 3.58276e-05
q-value 3.58276e-05
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.94912e-05
E-value 0.0733648
q-value 0.0366824
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.94912e-05
E-value 0.0733648
q-value 0.0366824
Overlap 10
Offset 0
Orientation Normal
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Matches to Query: tro15-k4me1-7_e_31_0.516

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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.60821e-06
E-value 0.0060533
q-value 0.0060533
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.60821e-06
E-value 0.0060533
q-value 0.0060533
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.59849e-06
E-value 0.0248367
q-value 0.0165578
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.24367e-05
E-value 0.0468118
q-value 0.0234059
Overlap 9
Offset 1
Orientation Reverse Complement
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Matches to Query: tro17-k27ac-2_h_k4me1_1_0.548

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Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.81464e-06
E-value 0.0181223
q-value 0.0185738
Overlap 9
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.23462e-06
E-value 0.0234671
q-value 0.0185738
Overlap 10
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD3_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.40189e-06
E-value 0.0278607
q-value 0.0185738
Overlap 10
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.13412e-05
E-value 0.0803282
q-value 0.0401641
Overlap 9
Offset -1
Orientation Reverse Complement
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Matches to Query: tro20-k27ac-14_h_2_0.592

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Summary 

Alignment 

Name TEAD1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.08958e-07
E-value 0.000410117
q-value 0.00050357
Overlap 9
Offset -1
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name TEAD4_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.33786e-07
E-value 0.00050357
q-value 0.00050357
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name TEAD3_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.85806e-07
E-value 0.00107578
q-value 0.000717183
Overlap 10
Offset 7
Orientation Normal
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Summary 

Alignment 

Name TEAD1_MA0090.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.55407e-07
E-value 0.00246695
q-value 0.00098678
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name TEF_01_M01305_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.55407e-07
E-value 0.00246695
q-value 0.00098678
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name TEAD1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 8.14098e-07
E-value 0.00306427
q-value 0.00102142
Overlap 10
Offset 7
Orientation Normal
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Summary 

Alignment 

Name TEAD3_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.64522e-07
E-value 0.00363046
q-value 0.00103727
Overlap 8
Offset -2
Orientation Normal
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Summary 

Alignment 

Name ABAA_01_M00027_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.49144e-06
E-value 0.00937778
q-value 0.00234444
Overlap 10
Offset 4
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 44.495 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.