TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

h115-k36me3-2_e_4_0.758
GTCTCGAACT
1 RPC155_01_M01798_T
h117-k36me3-10_e_k36me3_24_0.599,h117-k9me3-7_e_k36me3_24_0.419
AGGAGTTCG
1 RPC155_01_M01798_T
h120-k27ac-6_re_35_0.371
CTCGAACTCC
1 RPC155_01_M01798_T
h120-k27ac-8_re_167_0.371
AACTCCTGA
0
h120-k27me3-5_re_47_0.365
CTCGAACTCC
1 RPC155_01_M01798_T
h1v10msc-k36me3-2_e_k36me3-h1_0.653
GGAGTTCGAGACC
2 RPC155_01_M01798_T,  BDP1_01_M01796_T
h1v10npc-k36me3-5_e_k36me3-h1_0.644
GGAGTTCGA
1 RPC155_01_M01798_T
mes15-k36me3-7_e_24_0.667
TCTCGAACTC
2 RPC155_01_M01798_T,  BDP1_01_M01796_T
mes17-k9me3-12_e_k36me3_64_0.432
AGGAGTTCG
0
mes20-k27ac-8_re_71_0.379
GGAGGTCGA
0
mes20-k27me3-1_re_20_0.376
GGAGTTCGAGA
1 RPC155_01_M01798_T
mes20-k4me3-9_re_124_0.320
AACTCCTGA
0
mes20-k9me3-9_re_48_0.426
AGGAGTTCG
0
msc15-k36me3-1_e_11_0.628
GGAGTTCGAGG
0
msc15-k36me3-6_e_84_0.595
CAGGAGTTCA
0
msc20-k27ac-17_re_68_0.397
AGTTCGAGA
0
msc20-k4me1-2_re_8_0.322
AGGAGTTCGA
1 RPC155_01_M01798_T
npc20-k27me3-9_re_57_0.377
GGAGTTCGAG
1 RPC155_01_M01798_T
npc20-k36me3-14_re_35_0.373
AGGAGTTCG
0
npc20-k4me1-1_re_2_0.329
TCTCGAACTCC
1 RPC155_01_M01798_T
tro15-k36me3-5_e_4_0.739
AGGAGTTCGAG
1 RPC155_01_M01798_T
tro17-k27me3-7_e_k36me3_83_0.368,tro17-k36me3-6_e_k36me3_83_0.613,tro17-k9me3-9_e_k36me3_83_0.416
CAGGAGTTCA
1 RPC155_01_M01798_T
tro17-k36me3-14_e_k36me3_28_0.596,tro17-k9me3-12_e_k36me3_28_0.422
AGTTCGAGA
0
tro20-k27ac-15_re_103_0.410
GGAGTTGGA
0
tro20-k27ac-4_re_145_0.386
CAGGAGTTCA
1 RPC155_01_M01798_T
tro20-k27me3-9_re_31_0.349
CTCGAACTCC
1 RPC155_01_M01798_T
tro20-k4me3-7_re_61_0.364
CAGGAGTTCA
1 RPC155_01_M01798_T
tro20-k9me3-3_re_1_0.383
TCTCGAACTCCT
1 RPC155_01_M01798_T

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiTaipaleCmbned.meme 3764 2

Matches to Query: h115-k36me3-2_e_4_0.758

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.45039e-06
E-value 0.0167513
q-value 0.0335025
Overlap 10
Offset 1
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: h117-k36me3-10_e_k36me3_24_0.599,h117-k9me3-7_e_k36me3_24_0.419

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.01995e-05
E-value 0.0760309
q-value 0.152062
Overlap 9
Offset 2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: h120-k27ac-6_re_35_0.371

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.06782e-06
E-value 0.0266033
q-value 0.0532066
Overlap 10
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: h120-k27ac-8_re_167_0.371

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Matches to Query: h120-k27me3-5_re_47_0.365

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.4932e-06
E-value 0.0131484
q-value 0.0262968
Overlap 10
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: h1v10msc-k36me3-2_e_k36me3-h1_0.653

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.58602e-08
E-value 9.73379e-05
q-value 0.000194676
Overlap 13
Offset 3
Orientation Normal
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name BDP1_01_M01796_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.17216e-06
E-value 0.019468
q-value 0.019468
Overlap 12
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: h1v10npc-k36me3-5_e_k36me3-h1_0.644

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.76178e-06
E-value 0.0254514
q-value 0.0509027
Overlap 9
Offset 3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: mes15-k36me3-7_e_24_0.667

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.21616e-08
E-value 0.000346896
q-value 0.000693792
Overlap 10
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name BDP1_01_M01796_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.59187e-05
E-value 0.0975579
q-value 0.0975579
Overlap 10
Offset 2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Query Top]

Matches to Query: mes17-k9me3-12_e_k36me3_64_0.432

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Matches to Query: mes20-k27ac-8_re_71_0.379

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Matches to Query: mes20-k27me3-1_re_20_0.376

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.50007e-06
E-value 0.0131743
q-value 0.0263485
Overlap 11
Offset 3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: mes20-k4me3-9_re_124_0.320

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Matches to Query: mes20-k9me3-9_re_48_0.426

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Matches to Query: msc15-k36me3-1_e_11_0.628

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Matches to Query: msc15-k36me3-6_e_84_0.595

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Matches to Query: msc20-k27ac-17_re_68_0.397

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Matches to Query: msc20-k4me1-2_re_8_0.322

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.60734e-06
E-value 0.00605003
q-value 0.0121001
Overlap 10
Offset 2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: npc20-k27me3-9_re_57_0.377

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.64763e-06
E-value 0.0212577
q-value 0.0425154
Overlap 10
Offset 3
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: npc20-k36me3-14_re_35_0.373

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Matches to Query: npc20-k4me1-1_re_2_0.329

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.21909e-06
E-value 0.00458864
q-value 0.00917729
Overlap 11
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: tro15-k36me3-5_e_4_0.739

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.28521e-07
E-value 0.00123655
q-value 0.00247311
Overlap 11
Offset 2
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: tro17-k27me3-7_e_k36me3_83_0.368,tro17-k36me3-6_e_k36me3_83_0.613,tro17-k9me3-9_e_k36me3_83_0.416

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.33517e-06
E-value 0.0238456
q-value 0.0476911
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: tro17-k36me3-14_e_k36me3_28_0.596,tro17-k9me3-12_e_k36me3_28_0.422

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Matches to Query: tro20-k27ac-15_re_103_0.410

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Matches to Query: tro20-k27ac-4_re_145_0.386

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.38436e-05
E-value 0.0521074
q-value 0.104215
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: tro20-k27me3-9_re_31_0.349

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.18583e-06
E-value 0.00446345
q-value 0.00892689
Overlap 10
Offset 3
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]

Matches to Query: tro20-k4me3-7_re_61_0.364

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.85717e-06
E-value 0.00699038
q-value 0.0139808
Overlap 10
Offset 1
Orientation Normal
Create custom LOGO ↧  [Query Top]

Matches to Query: tro20-k9me3-3_re_1_0.383

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Summary 

Alignment 

Name RPC155_01_M01798_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.35687e-07
E-value 0.00352193
q-value 0.00704385
Overlap 12
Offset 2
Orientation Reverse Complement
Create custom LOGO ↧  [Query Top]
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 95.938 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.