TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

mes15-k27ac-24_e_0_0.544
CCCCCGCCCCGGC
28 SP4_Q5_M01273_T,  SP1_Q2_01_M00933_T,  SP1_Q6_M00196_T,  SP1_Q6_01_M00931_T,  SP1_Q4_01_M00932_T,  SP1_02_M01303_T,  SP1_MA0079.2_J,  Zfp410_secondary_SCI09_U,  GC-box_POL003.1_J,  GC_01_M00255_T
msc17-k27me3-4_e_k4me3_2_0.600
CCCCGCCCC
20 SP1_Q6_01_M00931_T,  SP1_Q2_01_M00933_T,  SP1_Q6_M00196_T,  SP4_Q5_M01273_T,  SP1_02_M01303_T,  SP1_Q4_01_M00932_T,  SP1_MA0079.2_J,  GC-box_POL003.1_J,  GC_01_M00255_T,  SP1_01_M00008_T
npc17-k36me3-8_e_k4me3_72_0.433
GGCGGGGAA
2 ZMS1_01_M01617_T,  ZMS1_MA0441.1_J

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiTaipaleCmbned.meme 3764 31

Matches to Query: mes15-k27ac-24_e_0_0.544

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Summary 

Alignment 

Name SP4_Q5_M01273_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.0892e-10
E-value 1.91557e-06
q-value 3.78237e-06
Overlap 11
Offset 0
Orientation Normal
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Summary 

Alignment 

Name SP1_Q2_01_M00933_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 8.08662e-09
E-value 3.0438e-05
q-value 1.82506e-05
Overlap 10
Offset -1
Orientation Normal
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Summary 

Alignment 

Name SP1_Q6_M00196_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.57195e-09
E-value 3.60288e-05
q-value 1.82506e-05
Overlap 12
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_Q6_01_M00931_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.8225e-09
E-value 3.69719e-05
q-value 1.82506e-05
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_Q4_01_M00932_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.72892e-08
E-value 6.50764e-05
q-value 2.56992e-05
Overlap 12
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_02_M01303_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.81463e-08
E-value 0.000181223
q-value 5.96385e-05
Overlap 10
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_MA0079.2_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.45305e-07
E-value 0.000546928
q-value 0.000154276
Overlap 10
Offset -1
Orientation Normal
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Summary 

Alignment 

Name Zfp410_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.21168e-07
E-value 0.00158528
q-value 0.000391274
Overlap 13
Offset 2
Orientation Normal
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Summary 

Alignment 

Name GC-box_POL003.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 8.32027e-07
E-value 0.00313175
q-value 0.000618376
Overlap 12
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name GC_01_M00255_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 8.32027e-07
E-value 0.00313175
q-value 0.000618376
Overlap 12
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name Bcl6b_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.26444e-06
E-value 0.00475936
q-value 0.000854321
Overlap 13
Offset 1
Orientation Normal
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Summary 

Alignment 

Name SP1_01_M00008_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.42583e-06
E-value 0.00536684
q-value 0.000883086
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Ascl2_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.39198e-06
E-value 0.0090034
q-value 0.00127549
Overlap 13
Offset 3
Orientation Normal
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Summary 

Alignment 

Name PGAM2_4_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.40264e-06
E-value 0.00904355
q-value 0.00127549
Overlap 8
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.83136e-06
E-value 0.0106572
q-value 0.00140288
Overlap 11
Offset 0
Orientation Normal
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Summary 

Alignment 

Name KROX_Q6_M00982_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.2011e-06
E-value 0.012049
q-value 0.00148695
Overlap 10
Offset 4
Orientation Normal
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Summary 

Alignment 

Name CKROX_Q2_M01175_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.90555e-06
E-value 0.0147005
q-value 0.00170745
Overlap 9
Offset -1
Orientation Normal
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Summary 

Alignment 

Name Zfp281_primary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.14554e-06
E-value 0.0156038
q-value 0.00171168
Overlap 13
Offset 2
Orientation Normal
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Summary 

Alignment 

Name SP3_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.49546e-06
E-value 0.0169209
q-value 0.00175847
Overlap 11
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Klf7_primary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.08997e-06
E-value 0.0191586
q-value 0.00187854
Overlap 13
Offset 3
Orientation Normal
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Summary 

Alignment 

Name GKLF_02_M01588_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.30791e-06
E-value 0.019979
q-value 0.00187854
Overlap 12
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Smad3_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.48963e-06
E-value 0.024427
q-value 0.00219236
Overlap 13
Offset 3
Orientation Normal
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Summary 

Alignment 

Name KLF16_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.02146e-06
E-value 0.0264288
q-value 0.00226669
Overlap 11
Offset 0
Orientation Normal
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Summary 

Alignment 

Name SP1_MA0079.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.31963e-06
E-value 0.0275511
q-value 0.00226669
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name YGR067C_MA0425.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.46054e-06
E-value 0.0356095
q-value 0.00281249
Overlap 13
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Sp4_primary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.61446e-05
E-value 0.0607684
q-value 0.00461498
Overlap 13
Offset 1
Orientation Normal
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Summary 

Alignment 

Name KLF15_Q2_M01714_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.26819e-05
E-value 0.0853745
q-value 0.00621308
Overlap 12
Offset -1
Orientation Reverse Complement
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Summary 

Alignment 

Name Zfp740_primary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.34072e-05
E-value 0.0881047
q-value 0.00621308
Overlap 13
Offset 1
Orientation Normal
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Matches to Query: msc17-k27me3-4_e_k4me3_2_0.600

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Summary 

Alignment 

Name SP1_Q6_01_M00931_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.51407e-08
E-value 9.46296e-05
q-value 9.91679e-05
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_Q2_01_M00933_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.59901e-08
E-value 0.000135467
q-value 9.91679e-05
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name SP1_Q6_M00196_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.9959e-08
E-value 0.000150406
q-value 9.91679e-05
Overlap 9
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name SP4_Q5_M01273_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.39851e-08
E-value 0.0002032
q-value 0.000100483
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name SP1_02_M01303_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.52122e-07
E-value 0.000572586
q-value 0.000196673
Overlap 9
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_Q4_01_M00932_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.58496e-07
E-value 0.000596577
q-value 0.000196673
Overlap 9
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_MA0079.2_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.23872e-07
E-value 0.000842654
q-value 0.000238111
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name GC-box_POL003.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.12563e-07
E-value 0.00230569
q-value 0.000456352
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name GC_01_M00255_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.12563e-07
E-value 0.00230569
q-value 0.000456352
Overlap 9
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name SP1_01_M00008_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.12946e-07
E-value 0.00230713
q-value 0.000456352
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name KROX_Q6_M00982_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 8.79042e-07
E-value 0.00330871
q-value 0.00059497
Overlap 9
Offset 5
Orientation Normal
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Summary 

Alignment 

Name SP1_MA0079.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.27769e-06
E-value 0.00480924
q-value 0.000792727
Overlap 9
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name Zfp410_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.17884e-06
E-value 0.00820117
q-value 0.00124785
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Klf7_primary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.45178e-06
E-value 0.00922851
q-value 0.00130386
Overlap 9
Offset 4
Orientation Normal
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Summary 

Alignment 

Name PGAM2_4_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.98172e-06
E-value 0.0112232
q-value 0.00147997
Overlap 8
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name CKROX_Q2_M01175_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.92695e-06
E-value 0.0147811
q-value 0.00181052
Overlap 9
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Bcl6b_secondary_SCI09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.13403e-06
E-value 0.0155605
q-value 0.00181052
Overlap 9
Offset 2
Orientation Normal
Create custom LOGO ↧ [Previous Match] [Next Match] [Query Top]

Summary 

Alignment 

Name SP1_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.51347e-06
E-value 0.0169887
q-value 0.00186688
Overlap 9
Offset 1
Orientation Normal
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Summary 

Alignment 

Name ZFP281_01_M01597_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.03643e-05
E-value 0.0390111
q-value 0.00406128
Overlap 9
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name KLF16_monomeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.23489e-05
E-value 0.0464811
q-value 0.004597
Overlap 9
Offset 1
Orientation Normal
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Matches to Query: npc17-k36me3-8_e_k4me3_72_0.433

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Summary 

Alignment 

Name ZMS1_01_M01617_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.57754e-06
E-value 0.00970186
q-value 0.0192733
Overlap 8
Offset -1
Orientation Reverse Complement
Create custom LOGO ↧  [Next Match] [Query Top]

Summary 

Alignment 

Name ZMS1_MA0441.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.31118e-05
E-value 0.0493529
q-value 0.0490211
Overlap 9
Offset 0
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 13.630 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.