TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

msc15-k4me1-24_e_3_0.527
CACGTGCACT
5 CBF1_02_M01699_T,  Mycn_MA0104.1_J,  Arnt_MA0004.1_J,  USF1_7_H,  MYC_Q2_M00799_T
msc17-k27ac-3_e_k4me1_1_0.446
CACGTGCACC
7 CBF1_02_M01699_T,  Mycn_MA0104.1_J,  Arnt_MA0004.1_J,  USF1_7_H,  MYC_Q2_M00799_T,  Pho4_GR09_U,  PHO4_02_M01564_T
msc17-k4me1-3_e_k4me1_2_0.560
CACACGTGCC
12 CBF1_02_M01699_T,  Mycn_MA0104.1_J,  HEY1_dimeric_0_P,  HEY2_dimeric_0_P,  Arnt_MA0004.1_J,  PIF1_01_M01585_T,  MYC_Q2_M00799_T,  MNT_dimeric_0_P,  NMYC_01_M00055_T,  USF1_7_H
npc20-k27ac-38_re_189_0.445
CACGTGCCAG
22 Arnt_MA0004.1_J,  CBF1_02_M01699_T,  HES5_dimeric_0_P,  HES7_dimeric_0_P,  Mycn_MA0104.1_J,  HES5_dimeric_1_P,  CBF1_01_M01577_T,  Cbf1_GR09_U,  MYC_Q2_M00799_T,  USF1_7_H

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

trnsfcJsprUnprobHpdiTaipaleCmbned.meme 3764 29

Matches to Query: msc15-k4me1-24_e_3_0.527

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Summary 

Alignment 

Name CBF1_02_M01699_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.88847e-07
E-value 0.00108722
q-value 0.00106057
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.3691e-06
E-value 0.00515329
q-value 0.0033513
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Arnt_MA0004.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 8.79367e-06
E-value 0.0330994
q-value 0.00935298
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name USF1_7_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.10517e-05
E-value 0.0415985
q-value 0.00935298
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MYC_Q2_M00799_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.14629e-05
E-value 0.0431462
q-value 0.00935298
Overlap 7
Offset 0
Orientation Normal
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Matches to Query: msc17-k27ac-3_e_k4me1_1_0.446

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Summary 

Alignment 

Name CBF1_02_M01699_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.35208e-07
E-value 0.000508922
q-value 0.000987908
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.03958e-06
E-value 0.00391298
q-value 0.00253193
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Arnt_MA0004.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.53335e-06
E-value 0.0208275
q-value 0.00681727
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name USF1_7_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.46423e-06
E-value 0.0280954
q-value 0.00681727
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MYC_Q2_M00799_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.04542e-06
E-value 0.0340469
q-value 0.00734347
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Pho4_GR09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.06306e-05
E-value 0.0776538
q-value 0.0147467
Overlap 10
Offset 7
Orientation Normal
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Summary 

Alignment 

Name PHO4_02_M01564_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.2201e-05
E-value 0.0835644
q-value 0.0147467
Overlap 10
Offset 7
Orientation Normal
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Matches to Query: msc17-k4me1-3_e_k4me1_2_0.560

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Summary 

Alignment 

Name CBF1_02_M01699_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 3.38846e-09
E-value 1.27542e-05
q-value 2.47529e-05
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.06333e-06
E-value 0.00400238
q-value 0.00258923
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name HEY1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.23688e-06
E-value 0.00841961
q-value 0.00408513
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name HEY2_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.93925e-06
E-value 0.0110633
q-value 0.00421415
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name Arnt_MA0004.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.03818e-06
E-value 0.0151997
q-value 0.00421415
Overlap 6
Offset -2
Orientation Reverse Complement
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Summary 

Alignment 

Name PIF1_01_M01585_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 4.95899e-06
E-value 0.0186656
q-value 0.00431417
Overlap 10
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name MYC_Q2_M00799_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.31516e-06
E-value 0.0200062
q-value 0.00431417
Overlap 7
Offset -2
Orientation Normal
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Summary 

Alignment 

Name MNT_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 7.5236e-06
E-value 0.0283188
q-value 0.00499639
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name NMYC_01_M00055_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 9.08891e-06
E-value 0.0342107
q-value 0.00553291
Overlap 10
Offset 1
Orientation Normal
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Summary 

Alignment 

Name USF1_7_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.07923e-05
E-value 0.0406221
q-value 0.00606447
Overlap 6
Offset -2
Orientation Normal
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Summary 

Alignment 

Name MAX_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.53032e-05
E-value 0.0576013
q-value 0.00749963
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name HEY2_dimeric_1_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.0865e-05
E-value 0.078536
q-value 0.00952626
Overlap 10
Offset 0
Orientation Reverse Complement
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Matches to Query: npc20-k27ac-38_re_189_0.445

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Summary 

Alignment 

Name Arnt_MA0004.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.51189e-06
E-value 0.00945475
q-value 0.0043085
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name CBF1_02_M01699_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.51189e-06
E-value 0.00945475
q-value 0.0043085
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name HES5_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.95815e-06
E-value 0.0111345
q-value 0.0043085
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name HES7_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.95815e-06
E-value 0.0111345
q-value 0.0043085
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Mycn_MA0104.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.03744e-06
E-value 0.0189609
q-value 0.0043226
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name HES5_dimeric_1_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 5.3421e-06
E-value 0.0201077
q-value 0.0043226
Overlap 9
Offset 3
Orientation Normal
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Summary 

Alignment 

Name CBF1_01_M01577_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.69024e-06
E-value 0.0251821
q-value 0.00442919
Overlap 10
Offset 8
Orientation Reverse Complement
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Summary 

Alignment 

Name Cbf1_GR09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 6.69024e-06
E-value 0.0251821
q-value 0.00442919
Overlap 10
Offset 8
Orientation Reverse Complement
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Summary 

Alignment 

Name MYC_Q2_M00799_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.45289e-05
E-value 0.0546868
q-value 0.00634879
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name USF1_7_H
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.63454e-05
E-value 0.061524
q-value 0.00634879
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name CG1_Q6_M00440_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.69867e-05
E-value 0.0639378
q-value 0.00634879
Overlap 9
Offset 2
Orientation Normal
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Summary 

Alignment 

Name MAX_dimer-of-dimers_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 1.73281e-05
E-value 0.065223
q-value 0.00634879
Overlap 10
Offset 0
Orientation Normal
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Summary 

Alignment 

Name HEY1_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.16242e-05
E-value 0.0813936
q-value 0.00634879
Overlap 8
Offset 2
Orientation Normal
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Summary 

Alignment 

Name HEY2_dimeric_0_P
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.16242e-05
E-value 0.0813936
q-value 0.00634879
Overlap 8
Offset 2
Orientation Normal
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Summary 

Alignment 

Name HLH-26_Cell09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.18234e-05
E-value 0.0821432
q-value 0.00634879
Overlap 10
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name RTG3_01_M01580_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.18742e-05
E-value 0.0823345
q-value 0.00634879
Overlap 10
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name RTG3_MA0376.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.18742e-05
E-value 0.0823345
q-value 0.00634879
Overlap 10
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name Rtg3_GR09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.18742e-05
E-value 0.0823345
q-value 0.00634879
Overlap 10
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name REF-1_Cell09_U
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.35385e-05
E-value 0.0885991
q-value 0.00634879
Overlap 10
Offset 5
Orientation Reverse Complement
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Summary 

Alignment 

Name hlh-26_PL0009.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.35385e-05
E-value 0.0885991
q-value 0.00634879
Overlap 10
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name STRA13_01_M00985_T
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.51774e-05
E-value 0.0947678
q-value 0.00637184
Overlap 10
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name ref-1_PL0016.1_J
Database trnsfcJsprUnprobHpdiTaipaleCmbned.meme
p-value 2.53739e-05
E-value 0.0955074
q-value 0.00637184
Overlap 10
Offset 5
Orientation Reverse Complement
Create custom LOGO ↧ [Previous Match] [Query Top]
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TOMTOM version
4.8.1 (Release date: Tue Feb 7 14:03:40 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.295   C: 0.205   G: 0.205   T: 0.295

Result calculation took 15.152 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.