DNA motifs regulating histone modifications in human and mouse

We present here the results for motifs that correlates with histone modifications in human and mouse.

We have analysed ENCODE Consortium data for eight histone modifications (H3K4me1, H3K4me2, H3K4me3, H3K27ac, H3K27me3, H3K9ac, H3K9me3, H3K36me3) across 12 mouse embryonic tissues and 8 developmental stages as well as six histone modifications (excluding H3K4me2 and H3K9ac) across 121 human cell types and tissues from the Roadmap Epigenomics Project

Results included the most interesting motif clusters for each species as well as the complete set of motifs produced by Epigram, organized by their clusters.

Vu Ngo^1#, Zhao Chen^2#, Kai Zhang¹, John W. Whitaker², Mengchi Wang¹, Wei Wang^1,2,3*
1. Graduate Program of Bioinformatics and Systems Biology,
2. Department of Chemistry and Biochemistry,
3. Department of Cellular and Molecular Medicine,
University of California, San Diego, La Jolla, CA 92093-0359

# Equal contribution
* Correspondence: wei-wang@ucsd.edu

(*) Signicant clusters were chosen such that in total, they contain roughly 50% of all motifs in the runs, and have enrichments for histone marks at p-value <=1e-3